L - (+) - Ergothioneine (EGT) (497-30-3)

March 15, 2020
SKU: 1010396-29-8

Ergothioneine iri amino acid inowanzoitika uye inogadzirwa ne thiourea ye histidine, ine atomu yesarufa pane …… ..


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

 

L - (+) - Ergothioneine (EGT) (497-30-3) vhidhiyo

L - (+) - Ergothioneine (EGT) powder Specifications

Product Name L - (+) - Ergothioneine (EGT)
Kemikari Name ERGOTHIONEINE;

L-Ergothioneine;

Sympectothion;

l ergothioneine

muchiso Name N / A
Kirasi yeMishonga N / A
CAS Number 497-30-3
InChIKey SSISHJJTAXXQAX-ZETCQYMHSA-N
Molecular Formula C9H15N3O2S
Molecular Wsere 229.3 g / mol
Monoisotopic Mass 229.088498 g / mol
Kubikira pfungwa  N / A
Freezing Point N / A
Biological Half-Life N / A
ruvara Yakachena kana iri-yakachena
Skukodzera  Soluble mu Mvura (kusvika 10 mg / ml)
Storage Temperature  -20 ° C
APane l ergothioneine poda yakashandiswa mune zvine hutano zvinowedzera

 

L - (+) - Ergothioneine (EGT) (497-30-3) Kuongorora

Ergothioneine iri amino acid inowanzoitika uye inotora thiourea ye histidine, iine atomu yesarufa pamhete ye imidazole. Musanganiswa uyu unogadzirwa muzvisikwa zvidiki, kunyanya Actinobacteria, Cyanobacteria, uye zvimwe fungi. Ergothioneine inoda mutakuri chaiwo, EGT, inozivikanwawo seOCTN1 (chiratidzo chejini SLC22A4), kuti ipinde masero. Kutaura kweEGT kwakasimbiswa mumitsara yemunhu neyemhuka uye kugona kwayo kutakura ergothioneine yakasimbiswa mu vivo.

L-ergothioneine inongoerekana yaitika amino acid uye iri thiol / thione rinobva histidine. L-ergothioneine inowanikwa yakanyanya kukwirira musango uye hutachiona uye mune yakaderera mune zvimwe zvekudya zvinosanganisira mambo crab, nyama yemombe, nyama yenguruve, gwayana uye huku.

Kunyangwe kuvepo kweL-ergothioneine mune zvekudya zvinoshandiswa nevanhu, yayo biosynthesis yakangoonekwa mune mamwe mabhakitiriya uye fungi.

 

Chii L - (+) - Ergothioneine (EGT) ?

L-Ergothioneine is amino acid iyo inowanikwa zvakanyanya mushwa, asiwo muna mambo crab, nyama kubva kumhuka dzakadya pauswa huswa iine ergothioneine, uye zvimwe zvekudya. Amino acid ndiwo makemikari ari iwo anovakira mapuroteni. Ergothioneine inoshandiswa semushonga.

Vanhu vanotora ergothioneine yekukuvara kwechiropa, cataract, chirwere cheAlzheimer, chirwere cheshuga, uye chirwere chemwoyo.

L - (+) - ERGOTHIO yakasikwa chiral amino-acid antioxidant biosynthesized mune mamwe mabhakitiriya uye fungi. Iyo yakakosha bioactive compound iyo yakashandiswa seyakanyanya scavenger, iyo Ultraviolet ray firita, iyo inogadzirisa oxidation-kuderedza maitiro uye cellular bioenergetics, uye physiological cytoprotector, nezvimwewo.

L-Ergothioneine dzimwe nguva inoiswa yakananga paganda kudzivirira mhezi, kuderedza zviratidzo zveganda rinokwegura, uye kuderedza kukuvara kwezuva.

 

L - (+) - Ergothioneine (EGT) inobatsirwa

L-ergothioneine yakasarudzika mukuti inogona kusvika pakati penzvimbo dzemamwe maseru senge erythrocyte, kusiyana nemamwe makirasi ekutanga antioxidants akadai mavitamin C uye E. Chaizvoizvo ine gene iyo macode protein inotakura, ichigonesa kuti itorwe kurudyi mwoyo wemasero. Nekudaro iyo ine potracellular antioxidant, yakakosha seL-glutathione. Mukuwedzera, iyo yakaratidzwawo kuve chelator ine simba, ichiigonesa kubatanidza kune chepfu zvinorema simbi, uku ichichengetedza masero eropa kubva kumhando dzese dzekukuvara.

Vakurudzirwa neayo antioxidant zvivakwa, vatsvagiri vakazoongorora zvayakaita zvinopesana nekuzvimba, nekuti ergothioneine inoita, pakati pevamwe, iyo pro-immune cytokine, interleukin. L - (+) - Ergothioneine (EGT) saka ine zvinhu zvakawanda zvinoshanda zvinoshanda mukati memuviri wemunhu:

  • chinotitenderedza inoshanda remojeni mamoreky (emahara radicals), nekudaro kurwisa oxidative kusagadzikana uye kuderedza kukuvadzwa kune mitochondrial DNA, oxidation yemapuroteni uye lipid peroxidation;
  • Chelates - kana misungo - dzakasiyana siyana simbi cations;
  • Inogona kumisa antioxidant enzyme dzakadai se glutathione peroxidase kana SOD, apo ichirambidza enzyme dzinogadzira superoxide yakanyanya;
  • Inoderedza oxidation yemarudzi akasiyana-siyana haemoprotein akadai sa hemoglobin uye myoglobin;
  • Inodzivirira mitochondria;
  • L-ergothioneinereduces inokuvadza inokuvadza UV mawarosi, seanodzivirira mumiriri weGanda Kutarisirwa.
  • Inochengetedza uye inochengetedza huwandu hwemamwe antioxidants akadai mavitamin C uye E, glutathione uye SOD;
  • Inodzivirira uropi kubva kuurotoxins uye nekudaro inotora chikamu chekudzivirira kupokana nekuziva kuderera
  • Inokurudzira cellular kufema uye mafuta lipolysis, nokudaro inowedzera simba uye simba mukurovedza muviri;
  • Kana ichibatanidzwa ne hyaluronic acid, glucosamine, collagen, yakaratidzirwa kudzikisa zvakanyanya kurwadziwa kwemajoini uye kuwedzera kufamba kwekubatana, kwakabatana zvakanyanya nehurombo hwemashure maitiro ebasa, mushure mekushandisa kwevhiki nhanhatu chete.

 

L - (+) - Ergothioneine (EGT) chengetedzo

Kunyangwe l-ergothioneine achigovana zita uye achigona kuuya kubva kune ergot fungus, haina chepfu munzira ipi neipi.

European Union ine yakasimba miitiro yekuwedzera kupfuura iyo yeUnited States uye yakatemera kuti l-ergothioneine inowedzera yakachengeteka uye haina kuburitsa zvakaipa mumakuru uye vana pamusoro.

Panel pane Dietetic Zvigadzirwa zveEuropean Food Safety Authority inoona kuti zvakachengeteka zuva nezuva zve2.82 mg / kg yehuremu hwemuviri wevacheche, 3.39 mg / kg yevana vadiki, uye 1.31 mg / kg yevakuru, kusanganisira vakadzi vane pamuviri uye vanoyamwisa.

 

L - (+) - Ergothioneine (EGT) hupfu tizvishandise uye kushandiswa

Kuwedzerwa kwakakodzera uye / kana kudya kunovandudzwa kunosanganisira hupenyu hurefu sevhithamini L-ergothioneine inogona kuderedza yakawanda mhedzisiro inowanzo yechirwere chisingaperi uye kukwegura kusati kwasvika.

L-ergothioneine poda inobatsira yakakodzera kune hutano hwakanaka, yehutano hwehutano hwehutano.

Tsvagiridzo inoratidza kuti EGT antioxidant inogona kuita seanorwisa-kuzvimba kuenderera mberi kudzivirira maseru pakurwisa kwemuviri uye neurodegenerative hosha.

  1. Kupisa

Kutsvagisa kunoratidza kuti se antioxidant, EGT inogona kudzivirira pakurwisa.

Rheumatoid arthritis ndeye autoimmune kusagadzikana kwakaratidzirwa nekunetseka kwakanyanya (uye kazhinji kusanzwisisika) kuzvimba.

Zvinogoneka kuti EGT inogona kudzora kuzvimba muvarwere vane rheumatoid arthritis.

  1. Neurodegenerative Diseases

Sa cytoprotectant, EGT inowedzera mukurumbira pakati pevarwere veAlzheimer's naParkinson.

EGT inotsigira muviri wako wepanyama antioxidant dziviriro system uye inogona kudzivirira maseru ehuropi kubva kukuvara kweiyo oxidative uye kushushikana kubva kune vakasununguka radicals

Nekudzivirira maseru ehuropi, zviripo kuti zvidzivirire kufa kweuropi munzvimbo yekutanga uye kudzivirira kubva kuzvirwere zvehutachiona.

  1. Chiropa Chirwere

Kutenda kune yayo cytoprotectant uye antioxidant kugona, EGT inofarira amino acid mune varwere vane chirwere chechiropa.

  1. Anti-Kukwegura Zvinogona

Iwe unowanzo tsvaga EGT mune zvakawanda zvigadzirwa zvekuchengetedza ganda nekuda kweayo cytoprotectant uye antioxidant zvivakwa- izvo zvinogona kudzivirira maseru eganda kubva kukuvara kweiyo oxidative.

Yemahara yakanyanya kukuvara uye oxidative kushushikana ndiyo mikuru inobatsira pakuchembera kusati kwasvika, sagging ganda, uye makumbo.

  1. Zvirwere zveRung

Dhipatimendi reDziviriro muUS rakapa rubatsiro rwemadhora zana nemakumi matatu nemakumi matatu emadhora kune vaongorori paYunivhesiti yeColorado kuti vadzidze maitiro eEXT antioxidant yekurwisa chirwere chemapapu pakurwisa veteran.

 

Reference:

  • Oumari M, et al. Kugadzwazve kwe ergothioneine mushure mekuita ne singlet oxygen. Mahara Radic Biol Med. 2019 Kubvumbi;
  • Cheah, LK, Halliwell, B. Ergothioneine; antioxidant inogona, basa remuviri uye basa muchirwere, Biochim. Biophys. Acta 2012; (5): 784-793.
  • Genghof, DS Biosynthesis ye Ergothioneine uye Hercynine na. Fungi uye Actinomycetales, J. Bacteriol., 1970; 103 (2): 475-478.
  • Repine, JE, Elkins, ND Mhedzisiro ye ergothioneine pane akakuvadzwa kwemapapu kukuvara uye kuzvimba mune cytokine insufflated makonzo, Prev. Med. 2012; (54): S79-S82.
  • EFSA Panel pane Dietetic Zvigadzirwa, Nutrition uye Allergies (2017). "Chirevo pamusoro pekuchengetedzwa kweyakagadzirwa l-ergothioneine sechikafu cheinovhiya - yekuwedzera yekudyidzana yekuratidzira uye yekuchengetedza kuongororwa kwevacheche nevana vadiki, vakadzi vane pamuviri uye vanoyamwisa". EFSA Chinyorwa. 15 (11): 5060. doi: 10.2903 / j.efsa.2017.5060.