α-ketoglutaric

Phcoker ine kugona kugadzirwa kwakawanda uye kupihwa kweCalcium 2-oxoglutarate uye Alpha-Ketoglutaric Acid pasi pemamiriro e cGMP.

Ndeapi mamwe mazita anonzi Alpha-ketgoglutaric acide inozivikanwa na?

A-cétoglutarate, A-Ketoglutaric Acid, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alfa-Cétoglutarate Categate deAlgine, Alpha-Cétoglutarate d'Arginine, , Alpha-Cétoglutarate de Glutamine, Alpha-Cétoglutarate de L-Arginine, Alpha-Cétoglutarate de L-Leucine, Alpha-Cétoglutarate de Taurine, Alpha Keto Glutaric Acid, Alpha Ketoglutarate, Alpha Ketoglutaric Acid, Alpha KG, Alpha KG, Alpha KG, -Ketoglutarate, Calcium Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate, 2-Oxoganatearic, Acid.

Chii chinonzi Alpha-Ketoglutaric acid?

Alpha-ketoglutaric (AKG) is organic organic iyo yakakosha kune chaiyo metabolism yezvinhu zvese zvakakosha amino acids uye kuendesa kweseru maseru mune iyo citric acid kutenderera. Icho chinotungamira kune glutamic acid, iyo isiri yakakosha amino acid inobatanidzwa mupuroteni synthesis uye kudzora kwemazinga eropa glucose. Mukubatana neL-glutamate, AKG inogona kudzikisa huwandu hweammonia hwakaumbwa muuropi, mhasuru neitsvo, pamwe nekubatsira kuyerwa kemitrogen yemuviri uye kudzivirira nitrogen yakawandisa mumatumbu emuviri nemvura. Vanhu vane yakakwira mapuroteni kudya, hutachiona hutachiona, kana mudumbu dysbiosis inogona kubatsirwa kubva kune yekuwedzera AKG kubatsira kuyera mamoniya mazinga uye kudzivirira matishu.

Vamwe vanhu vanotora alpha-ketoglutarate kunatsiridza yepamusoro mitambo. Vanopa zvekumhanya zvinovaka muviri zvekuwedzera zvinoti alpha-ketoglutaric acid inogona kunge iri yekuwedzera kwakakosha kune kudya kwakakodzera uye kudzidziswa kwemumhanyi anoda kuita kwakawanda. Ivo vanoisa izvi kuda pane zvidzidzo zvinoratidza kuti yakawedzera ammonia mumuviri inogona kusangana nealpha-ketoglutarate kudzikisira matambudziko ane hukama neamonia yakawanda (ammonia toxicity). Asi, kusvika parizvino, izvo chete zvidzidzo zvinoratidza alpha-ketoglutarate inogona kudzora huturu hweammonia yakaitwa muvarwere vehemodialysis.

Vatapi vezvehutano dzimwe nguva vanopa alpha-ketoglutarate intravenously (ne IV) yekudzivirira kukuvara kumoyo kunokonzerwa nezvinetso zvekuyerera kweropa panguva yekuvhiyiwa kwemoyo uye nekudzivirira kuparara kwemhasuru mushure mekuvhiyiwa kana kushungurudzika.

Maitiro ekuita kweAlpha-Ketoglutaric acid

Iyo chaiyo nzira yekuita ye α-Ketoglutarate haisati yajekeswa. Zvimwe zvezviitwa α-Ketoglutarate zvinosanganisira kuita muKrebs kutenderera senge yepakati, shanduko yekuchinja panguva yemetabolism yemamino acids, kuumba glutamic acid nekubatanidza neammonia, uye kudzikisa nitrogen nekubatanidza nayo futi. Nezve zviitwa α-Ketoglutarate nezviitwa neammonia, zvinokurudzirwa kuti α-Ketoglutarate inogona kubatsira varwere vane propionic academia vane huwandu hwakakwira hweammonia uye hwakaderera huwandu hwe glutamine / glutamate muropa ravo. Nekuti endogenous glutamate / glutamine inogadzirwa kubva ku α-Ketoglutarate, propionic acidemia varwere vane kukanganisika kugadzirwa kwe α-Ketoglutarate uye kuwedzera kwe α-Ketoglutarate inofanirwa kugadzirisa mamiriro evarwere ava. Zvimwe zvakati wandei zvekuyedza zvidzidzo zvakaratidzawo kuti manejimendi e α-Ketoglutarate mune parenteral chikafu chakapihwa kune post-operative varwere vakabatsira kudzikisira kuderera kwekutanga kwemasuru protein ayo anowanzoonekwa mushure mekuvhiyiwa. Izvi zvakaderera mhasuru synthesis inofungidzirwa kuve nekuda kwakanyanya kuderera α-Ketoglutarate mazinga.

Alpha ketoglutaric acid (AKG) inowedzera - Ndezvipi zvakanakira Alpha ketoglutaric acid?

Alpha-Ketoglutarate (AKG) seAtletic Performance Kuwedzera
Alpha ketoglutaric acid, kana Alpha-ketoglutarate chigadzirwa chemitochondria uye inoita basa rakakosha mukushandurwa kwechikafu kuita simba. Iyo zvakare sosi yegutamine uye glutamate. Mumhasuru, glutamine uye glutamate inhibit kuputsika kweprotein uye kuwedzera mapuroteni synthesis.

Alpha-ketoglutarate inowedzera mapfupa kuumbwa. Iyo inodzora iyo synthesis ye collagen pamwe nekuwedzera huwandu hwe mamorekuru anowanikwa pakuita. Collagen chinhu chakakosha chemapfupa emapfupa.

Alpha-ketoglutarate inomutsa kugadzirwa kwe insulin-senge kukura chinhu-1 uye kukura kemikari. Aya ndiwo ese mahormone anodzora kudzokorodza mapfupa uye kuumbwa kwemapfupa matsva.

alpha ketoglutaric acid inobatsira pakukwegura
Zvidzidzo zvakaratidza kuti AKG inogona kubata akawanda mamiriro kana ikatorwa sekurairwa.

Nekudaro, pane zvimwe zvinoratidza kuti Alpha-Ketoglutarate (AKG) inogona kubatsira neanopokana-kukwegura zvivakwa.

Imwe ongororo hombe yakaitiswa kuBuck Institute yeKutsvagisisa nezvekukwegura pamwe chete naPonce de Leon Health yakawana hutano hwakagadziriswa neanosvika makumi matanhatu muzana muchidzidzo chavo chemammalia.

α-ketoglutaric
AKG inowedzera hupenyu hwevakuru hweC. Elegans. (A) AKG inowedzera hupenyu hwehonye dzevanhu vakuru. (B) Dose-mhinduro curve yeAKG mhedzisiro yehupenyu hurefu.
Uye zvakare, Ponce De Lon Hutano (PDL) yakaburitsa gwaro rekuyedza, mushumo unoratidza kuti mushure mehafu yegore, zera repanyama rezvidzidzo rakadzikira paavhareji yemakore 8.5 mushure mekutora alpha-ketoglutarate (AKG) yaive mukambani.

Mamwe makemikari, senge antiaging drug rapamycin uye chirwere cheshuga kurapwa metformin, zvakaratidza zvakafanana mhedzisiro mumushonga wekuyedza. Asi AKG yakasikwa inogadzirwa nembeva uye nemiviri yedu, uye yatove kufungidzirwa kuti yakachengeteka kudyiwa nevatongi.

Izvo zvinhu zvatinofanira kuteerera ndezvokuti yakachena alpha ketoglutaric acid yakanyanyisa uye haina nyore kudya. Iko kusimba kwemuviri kunowedzera pamusika kunowedzerwa ne arginine-α-ketoglutarate (AAKG), chinhu chikuru chiri arginine, nepo iyo inoshandiswa naPonce De Lon Health iri α-ketoglutarate calcium.

Alpha-ketoglutarate zvakare ine immune-inosimudzira zvivakwa
AKG inonzi zvakare immune immune chinhu uye inoita basa rakakosha mune general immune metabolism. Izvo zvave kutozivikanwa kuti AKG chinhu chakakosha sosi ye glutamine uye glutamate, inotsanangurwa se glutamine homologue uye chinobva. Mumuviri, inoshandurwa kuita glutamine. Glutamine inogona kuwedzera masero machena eropa masero (macrophages uye neutrophils) .AKG se glutamine homologue ine immuno-inosimudzira zvivakwa, inogona kuchengetedza gumbo, inodzivirira maseru ekudzivirira uye chiitiko chenyutrophils uye phagocytosis, inoderedza kutapukirwa kwebhakitiriya mu vivo.

Dheuteronomio:

  1. Aussel C, Coudray-Lucas C, Lasnier E, uye al. Alpha-Ketoglutarate inotorwa muhunhu hwevanhu. Cell Biol Int 1996; 20: 359-63.
  2. Wernerman J, Hammarqvist F, Vinnars E. Alpha-ketoglutarate uye postoperative mhasuru catabolism. Lancet1990; 335: 701-3.
  3. Blomqvist BI, Hammarqvist F, von der Decken A, Wernerman J. Glutamine uye alpha-ketoglutarate inodzivirira kuderera kwemhasuru yemahara glutamine kusanganisa uye kukanganisa protein synthesis mushure mekuzara kwechiuno. Metabolism 1995; 44: 1215-22.
  4. Hammarqvist F, Wernerman J, von der Decken A, Vinnars E.Alpha-ketoglutarate inochengetedza protein synthesis uye yemahara glutamine mumasaga emhasuru mushure mekuvhiyiwa. Kuvhiya 1991; 109: 28-36.
  5. Zhang W, Qu J, Liu GH, uye al. Epigenome yekukwegura uye kumutsidzirwa kwayo [J]. Zvisikwa Ongororo Molecular Cell Biology, 2020, 21 (3).
  6. Rhoads TW, Anderson RM. Alpha-Ketoglutarate, iyo Metabolite iyo Inodzora Kukwegura muMakonzo [J]. Cell Metabolism, 2020.
  7. Alpha-Ketoglutarate, an Endogenous Metabolite, Inotambanudza Hupenyu hweHupenyu uye Inomanikidza Kurwara muKweguru Makonzo. Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ.