Urolithin upfu

Phcoker inokwanisa kugona kugadzirwa kwakawanda uye kuwanisa urolithin a, urolithin b uye Urolithin A 8-Methyl Ether pasi pemamiriro e cGMP.

Chii chinonzi Urolithin A?

Urolithin A chinhu chemetabolite chinokonzerwa nekushandurwa kwemaelgitannins nematumbu mabhakitiriya. Icho chiri chekirasi yemakemikari makemikari anozivikanwa se benzo-coumarins kana dibenzo-α-mapiramoni. Urolithin A yakaratidzirwa kukurudzira mitophagy uye nekuvandudza hutano hwemhasuru mumhuka dzekare uye mumatanho epamberi ekukwegura. Zvichakadaro, izvo zvakare zvakaratidzirwa kuyambuka iro reropa chipingaidzo, uye inogona kuve neuroprotective mhedzisiro kurwisa Alzheimer's Chirwere.

Urolithin A poda chigadzirwa chechisikigo chine antiproliferative uye antioxidant chiitiko. Urolithin A inoumbwa nemetabolism kubva kune polyphenols inowanikwa mune mamwe marimu nemichero, kunyanya matamba. Vapamberi vayo - ellagic acids uye ellagitannins - anowanikwa munzvimbo dzese, kusanganisira zvinodyiwa zvinodyiwa, zvakaita sematamba, sitirobheri, raspberries, walnuts, tii uye muscat mazambiringa, pamwe nemichero yakawanda yetropiki.

Kubva kuma2000, urolithin A yanga iri pasi pezvidzidzo zvekutanga zvine chekuita nezvezvinogona kuitika muhupenyu.

Urolithin A inoshanda sei?

Urolithin A iri urolithin, microbial human metabolite yezvokudya ellagic acid zvigadzirwa (senge ellagic acid). Mumatumbo metabolism yemabhakitiriya, ellagitannin uye ellagic acid inotungamira mukuumbwa Active urolithins A, B, C uye D. Pakati pavo, urolithin A (UA) ndiyo inonyanya kushanda uye inoshanda yematumbo yemetabolite, iyo inogona kushandiswa seyakanaka anti -inokuvadza uye antioxidant.

Mune zvidzidzo zvevarabhoritari, zvakaratidzirwa kuti urolithin A inokonzeresa mitochondria, inova ndiyo inosarudzika yekudzosa mitochondria kuburikidza nekuzvipira. Autophagy maitiro ekubvisa mitochondria isina kukwana mushure mekukuvara kana kushushikana, uye inoshanda panguva yekukwegura. pasi uye pasi. Mhedzisiro iyi yakaonekwa mumhando dzakasiyana dzemhuka (mammalian maseru, makonzo uye Caenorhabditis elegans).

Nekudaro, nekuti sosi ye ellagitannin yakasiyana, kuumbwa kweboka rega rega rebhakitiriya kuchave kwakasiyana, saka kugona kwekushandura kuita urolithin A kwakasiyana kwazvo muvanhu, uye vamwe vanhu vanogona kunge vasina chero shanduko.

Urolithin A inobatsira

Urolithin A (UA) chikafu chechisikigo, metabolite inotorwa kubva munharaunda yehutachiona. Iyo ine akasiyana siyana ehutano mabhenefiti, anosanganisira kudzikisa kuzvimba kusaina, anti-cancer mhedzisiro uye inhibiting lipid kuunganidza.

Seye anonyanya kushanda uye anoshanda mudumbu metabolite, urolithin A (UA) inogona kuita senge inoshanda inorwisa-kupisa uye antioxidant. Inogona zvakare kukurudzira mitochondrial phagocytosis mumhuka dzakura uye epamberi mamodheru ekukwegura uye nekuvandudza hutano hwemhasuru.

Inogona here iyo Urolithin A kushandiswa sekuwedzera?

Muna 2018, iyo US Chikafu neDrug Administration yakaratidza urolithin A sechinhu chakachengetedzeka muzvikafu kana zvekudya zvigadzirwa zvekuwedzera, nemari ichibva pamamirigiramu mazana maviri kusvika kugiramu rimwe pakushanda.

Pane chero mhedzisiro yeUrolithin A?

Zvidzidzo zvekuchengetedza muvakuru vakura zvakaratidza kuti urolithin A inoshivirirwa zvakanaka. Mune vivo zvidzidzo hazvina kuona kana paine chero chepfu kana zvimwe zvakashata zvinokanganisa zvekudya urolitin A kudya.

Zvakare, kuchengetedzwa kwenguva refu kwekuwedzera kweUrolithin A uye pomegranate hakuzivikanwe, asi kurapwa kwenguva pfupi neye pomegranate yakabviswa yakachengeteka.

Chii chinonzi Urolithin B? Urolithin B upfu?

Urolithin B powder (CAS HERE: 1139-83-9) iri urolithin, rudzi rwe phenolic makemikari anogadzirwa mumatumbu emunhu mushure mekumwa kwezvikafu zvine ellagitannins zvakadai sedamba, sitrobheri, raspberries tsvuku, walnuts kana waini tsvuku . Urolithin B inowanikwa mumuguta muchimiro cheurolithin B glucuronide.

Urolithin B inoderedza kuwora kweprotein uye inokonzeresa mhasuru hypertrophy. Urolithin B inodzivisa chiitiko chearomatase, enzyme inoshandura estrogen uye testosterone.

Urolithin B chigadzirwa chechisikigo chine antiproliferative uye antioxidant chiitiko. Urolithin B yakaratidzirwa kuyambuka iyo brain brain barrier, uye inogona kuve neuroprotective mhedzisiro kurwisa Alzheimer's Chirwere.

Urolithin B ndeye intestinal microbial metabolite ye ellagitannis uye inoratidza inokwanisa-anti-oxidant uye pro-oxidant activies zvinoenderana neye assay system nemamiriro ezvinhu. Urolithin B inogonawo kuratidza estrogenic uye / kana anti-estrogenic basa.

Chii chinonzi Urolithin B chinoshandiswa? Urolithin B (UB) mabhenefiti

Kubatsira kwaUrolithin B:

Inokurudzira Muscle Protein Synthesis

Inoderedza Muswe Mapuroteni Kuputsika

Unogona kuve neMhasuru Yekudzivirira Mhedzisiro

Iva NeAnti-Aromatase Properties

Urolithin B yemhasuru

Urolithin B inogona kudzikisira kukuvara kwemhasuru zvinowanikwa panguva yekurovedza muviri zvakanyanya uye kudzivirira tsandanyama kubva kuzvidya mwoyo zvinokonzerwa nechikafu chine mafuta mazhinji. Kwemakiriniki kutsvakurudza nezveUrolithin B mune mbeva akawana kuti yakavandudza myotubes kukura uye mutsauko nekuwedzera protein protein. Yakaratidza kugona kudzora ubiquitin-proteinasome gwara (UPP), ndiyo nzira huru yeprotein catabolism. Izvo zvakakonzeresa mhasuru hypertrophy uye yakaderedza tsandanyama atrophy.

Kana ichienzaniswa ne testosterone, Urolithin B paakatorwa pa15 M akawedzera androgen receptor chiitiko ne90% nepo testosterone yakangokwanisa kuita yakawedzera receptor chiitiko che50% pa100uM. Izvi zvinoreva kuti zvinotora yakaderera Urolithin B kuwedzera androgen basa zvakanyanya ipapo huwandu hwepamusoro hwe testosteronewhich hunowedzera androgen basa zvishoma.

Zvakare, inonyanya kushanda 15uM yeUrolithin B yakakura mapuroteni synthesis kuburikidza ne96% kana ichienzaniswa ne100uM ye insulin, iyo yakakura protein protein synthesis kuburikidza inonyanya kushanda 61%. Iko kudavira ndekwekuti zvinotora nzira refu zvakanyanya kushoma Urolithin B kuwedzera mhasuru yemapuroteni synthesis ine yakanyanya yepamusoro degree rekushanda.

Izvi zvidzidzo zvinoratidza kuti Urolithin B inogona kudzivirira mapuroteni catabolism nepo panguva imwecheteyo kuwedzera protein protein, ichi chinhu chakasarudzika chinobatsira kuvaka kunetepa kwemhasuru uku uchidzivirira kupwanya tsandanyama.

Urolithin B ndeimwe yematumbo microbial metabolites eellagitannins, uye ine anti-kupisa uye antioxidant mhedzisiro. Urolithin B inodzivisa chiitiko cheNF-κB nekudzikisa phosphorylation uye kudzikisira kweI VerBcy, uye inodzvinyirira iyo phosphorylation yeJNK, ERK, neAkt, uye inosimudzira phosphorylation ye AMPK. Urolithin B iri zvakare mutongi wemabhonzo emhasuru.

Chii chinonzi Urolithin A 8-Methyl Ether?

Urolithins ndeyechipiri metabolites yeiyo ellagic acid yakatorwa kubva kune ellagitannins. Muvanhu ellagitannins inoshandurwa neye gut microflora kuita ellagic acid iyo inoshandurwazve kuita urolithins A, urolithin B, urolithin C uye urolithin D mumatumbo mahombe.

Urolithin A 8-Methyl Ether ndiyo yepakati chigadzirwa panguva yekuumbwa kweUrolithin A. Iyo yakakosha yechipiri metabolite ye ellagitannin uye ine antioxidant uye anti-immune mali.

Urolithin A 8-Methyl Ether inoshanda sei?

(1) Antioxidant zvivakwa

Urolithin A 8-Methyl Ether ine antioxidant mhedzisiro nekuderedza mahara radicals, kunyanya kudzora huwandu hweanoshanda oksijeni marudzi (ROS) mumasero, nekudzivirira lipid peroxidation mune mamwe maseru marudzi.

(2) Anti-kuzvimba zvivakwa

Urolithin A 8-Methyl Ether ine anti-anogumbura zvinhu nekudzivirira kugadzirwa kwe nitric oxide. Ivo chaizvo vanodzivisa kutaura kweiyo inducible nitric oxide synthase (iNOS) protein uye mRNA inokonzera kuzvimba.

Urolithin A 8-Methyl Ether inobatsira

Urolithin A 8-Methyl Ether chigadzirwa chepakati muchikamu chekutanga cheUrolithin A, uye yakakosha yechipiri metabolite yeellagitannin, ine antioxidant uye inorwisa-kupisa zvinhu. Semetabolite yeUrolithin A, inogona zvakare kunge iine mabhenefiti eUrolithin A:

(1) Inogona kuwedzera hupenyu;
(2) Batsira kudzivirira gomarara reprostate;
(3) Kukurudzira kwekuziva.
(4) Kugona kwekudzikira uremu

Iko kushandiswa kweUrolithin A 8-Methyl Ether zvinowedzera?

Urolithin A zvinowedzerwa zvinowanikwa zviri nyore mumusika seylagitannin-yakafuma chikafu sosi inowedzera. Sechigadzirwa chemagetsi cheUrolithin A, Urolithin A 8-Methyl Ether inogona zvakare kushandiswa mukuwedzera.

Nekudaro, hapana akawanda madata nezve ayo ekuwedzera ruzivo, uye kumwe kutsvagurudza kunodiwa.

Dheuteronomio:

  1. Garcia-Munoz, Cristina; Vaillant, Fabrice (2014-12-02). "Metabolic Fate yeEllagitannins: Zvinoreva Hutano, uye Maonero Ekutsvagisa Ezvinhu Zvitsva Zvekudya". Kuongorora Kwakakosha muKudya Sayenzi uye Kudya. 54 (12): 1584-1598. doi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.
  2. Ryu, D. et al. Urolithin A induces mitophagy uye inowedzera hupenyu hwehupenyu muC C. elegans uye inowedzera mhasuru mashandiro mumakonzo. Nat. Med. 22, 879-888 (2016).
  3. "FDA GRAS chiziviso GRN Nhamba 791: urolithin A". US Kudya neDrug Administration. 20 Zvita 2018. Yakadzorerwa 25 Nyamavhuvhu 2020.
  4. Singh, A .; Andreux, P.; Blanco-Bose, W.; Ryu, D .; Aebischer, P.; Auwerx, J .; Rinsch, C. (2017-07-01). "Oral inogadziriswa urolithin A yakachengeteka uye inogadzirisa mhasuru uye mitochondrial biomarkers kune vakwegura". Innovation Mukukwegura. 1 (suppl_1): 1223-1224.
  5. Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Kuchengetedzwa kuongororwa kweurolithin A, metabolite inogadzirwa nehunhu hwemunhu microbiota pakudya kwekudya kwemuti wakatorwa ellagitannins uye ellagic acid". Chikafu uye Chemical Toxicology. 108 (Pt A): 289–297. doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.