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Pyrroloquinoline quinone (PQQ) (72909-34-3)

Pyrroloquinoline quinone (PQQ), inonziwo methoxatin, ndeye redox cofactor. Inowanikwa muvhu uye chikafu chakadai kiwifruit, se …… ..


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Pyrroloquinoline quinone (PQQ) (72909-34-3) Nhamba

Product Name Pyrroloquinoline quinone (PQQ)
Kemikari Name Coenzyme PQQ; Methoxatine; Pyrrolo-quinoline quinone;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

CAS Number 72909-34-3
InChIKey MMXZSJMASHPLLR-UHFFFAOYSA-N
kunyemwerera C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
Molecular Formula C14H6N2O8
Molecular Weight 330.21
Monoisotopic Mass 330.012415 g / mol
Boliing Point 1018.6 ± 65.0 ° C (Zvakafanotaurwa)
Flashing point 569.8 ° C (1,057.6 ° F; 842.9 K)
Density 1.963 ± 0.06 g / cm3 (Zvakafanotaurwa)
ruvara Orange-Tsvuku Yakasimba
Kuchengetedza temp 2-8 ° C
Solubility Kusunungura mumvura
kunyoresa PQQ inonzi yakamboshanda senge mumvura inogadziriswa vhitamini / cofactor uye seye antioxidant. Iyo zvakare yakagadzirirwa kushandiswa mune zvekudya zvinowedzera, senge simba, kuchinjiswa pakudya, uye nemabhawa akavakirirwa nezvimwe.

Chii Pyrroloquinoline quinone(PQQ)?

Pyrroloquinoline quinone (PQQ), inonziwo methoxatin, ndeye redox cofactor. Inowanikwa muvhu uye chikafu chakadai kiwifruit, pamwe nemukaka wemazamu wevanhu. Pyrroloquinoline quinone ndeye pyrroloquinoline ine mapoka e-oxo ku4 uye mashanu-chinzvimbo uye mapoka e-carboxy pane iyo 5-, 2- uye 7-chinzvimbo. Iyo ine basa sevhitamin-inogadziriswa yemvura uye cofactor. Uye, ndeye chiratidzo chinomiririra mapuroteni kinases inobatanidzwa mukusiyanisa kwemamalia maseru. Iyo yakakwira redox yekudzokorora kugona kwePQQ inogona kuipawo iyo pharmacological basa mukudzivirira kubva kune neurodegeneration uye kenza. (Semunhu anomirira redox, Pyrroloquinoline quinone yakanyatsogadzikana uye inogona kutora mukana mune mamwe mazana maitiro pane mamwe ma antioxidants, akadai ascorbic acid, quercetin, uye epicatechin.

Pyrroloquinoline quinone ingori biofactor, uye yaizivikanwa seye enzyme cofactor mumabhakitiriya. Tsvagurudzo dzinoratidza kuti Pyrroloquinoline quinone inogona kunge iripo munguva yepakutanga yekuzvarwa yekuzvarwa uye kushanduka. Sechikonzero chekukura kwezvirimwa, chiripo mukukura kwemhuka nevanhu. Pyrroloquinoline quinone inonzi inotora chikamu mune dzakasiyana siyana dzebasa rezvipenyu zvine hunhu hwakajeka hwekupona (semuenzaniso, kuvandudzwa kwekukwirirana kwemazano uye kuita kwekubereka) mumhuka.

Uyezve, Pyrroloquinoline quinone ine antioxidant uye B-vitamini-yakafanana nebasa, iine huwandu hwakawanda hwezvinobatsira zvehuropi nemuviri. Iyo inosimudzira hutano hwekuziva uye ndangariro nekurwisa mitochondrial dysfunction uye inochengetedza mauroni kubva mukukuvara kwe-oxidative. Zvidzidzo zvekiriniki muvanhu zvakaratidza kuti Pyrroloquinoline quinone inosimudzira kwenguva pfupi uye nekutarisisa, inovandudza simba metabolism uye kukwegura kune hutano, uye nekudzora mamakisi ekuzvimba, pamwe nekuvandudza manzwiro ekugara zvakanaka.

Pyrroloquinoline inoita sei quinone(PQQ) kushanda?

Zvidzidzo zvehando zvinoratidza kushamisa kunoshamisa kwePyrroloquinoline quinone mukusimudzira mitochondrial biogeneis. Rat hepatocytes yakafukidzwa nePQQ pa10-30 μM ye 24- 48 h yakaratidzirwa "yakawedzera citrate synthase uye cytochrome c oxidase chiitiko, Mitotracker staining, mitochondrial DNA yezvinhu, uye cellular oxygen kufema. Kuiswa kwemaitiro aya kwakaitika kuburikidza nekumiswa kweCAMP reaction element-binding protein (CREB) uye peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), nzira inozivikanwa kutonga mitochondrial biojiais. " Mune vivo zvidzidzo mumakonzo zvakare anoratidza migumisiro inobatsira kubva pakudya kwekuwedzeredza nePQQ (2mg PQQ / kg yechikafu). Izvi zvinosanganisira yakaderera plasma triglycerides, akawedzera mashandisiro esimba (akagadziridzwa ne hepatic mitochondrial yezvinhu), uye kuvandudza kuvimbika kune moyo wepiyo ischemia / reperfusion. Mhando dzekuedza dzekurwara nekurova kwemuzongoza dzinoratidza kuti Pyrroloquinoline quinone inowana kufa kwema cell, muchikamu kuburikidza nePyrroloquinoline quinone inochengetedza N-methyl-d-aspartic acid (NMDA) receptors. Mhando dzechirwere cheParkinson chirwere chinoratidza kuti Pyrroloquinoline quinone supplementation inoderedza kurasikirwa kwehoronal, inowedzera inoshanda yemweya oksijeni scavewering kugona, uye inopaweuroprotection kuburikidza nemamwe maitiro.

Zvakanakira Pyrroloquinoline quinone(PQQ) inobatsira

Mune uropi nemuviri, PQQ ine zvakawanda zvakasiyana siyana zvinobatsira.

- PQQ inotsigira yakaringana mitochondrial basa

Mitochondria ndivo vanogadzira simba mumaseru edu uye vanoita basa rakakosha muhutano hwedu hwese. PQQ nekudzivirira iripo mitochondria uye inosimudzira chizvarwa chechimochondrial, saka gadzira ATP (Energy). Yakawanda inoshanda mitochondria, isimba rakawanda.

-PQQ inotsigira nerve kukura zvinhu

PQQ inosimudzira kugadzirwa kweNerve Growth Factor (NGF.), Inochengetedza uye nekudzoreredza maseru neuropi, mabasa, uye kuchengetedzwa kubva pamwoyo uye yemitsipa ischemic zviitiko.

-PQQ inodzivirira oxidative kusagadzikana

PQQ inopa yakasimba antioxidant chengetedzo, inodzivirira masero mumuviri kubva ku oxidative kukuvara uye demage mahara radicals. Iyo inotsigira metabolism yesimba uye hutano hwekukwegura, uye yakafungidzirwa seinori cofactor ine antioxidant uye B vitamini-yakafanana nebasa.

Kunze kwezvo, PQQ inogona kuve nekudzivirira uye kurapa kukuvara kwechiropa uye yakasimba anticancer basa.

Iko kushandiswa / kushandiswa kwe Pyrroloquinoline quinone(PQQ)

Mune chidzidzo che2009 chakaburitswa mupepanhau rekurapa Chinyorwa Chekudya, Pyrroloquinoline Quinone yakaratidzwa kuve neanogona kubatsira kuchengetedza Iyo inoshandiswa kurapa kudzikisira kuderera (kurasikirwa ndangariro, kuoma kwekudzidza, nezvimwewo) nekuda kwezera, kurohwa kana chirwere chemitsipa, uye kuchengetedzwa kubva pamwoyo nemitsipa ischemic zviitiko. Mhedzisiro yakafanana yakataurwa mu 2011 yekutevera kudzidza uko Pyrroloquinoline Quinone yakapihwa zvakananga seyakawedzerwa zvekudya, senge mukaka-unobva pakudya chinwiwa chinwiwa.

Nzira yekukwana sei Pyrroloquinoline quinone(PQQ)?

Muhupenyu, iwe unogona kuwana imwe PQQ kubva kune zvimwe zvekudya zvine svutugadzike, inovapo mumhando dzakasiyana dzekudya uye zvinwiwa, zvinosanganisira green pepper, parsley, tii kana kiwifruit nezvimwe. Zvisinei, kana ukaverenga huwandu hwechikafu munhu chaanodya mazuva ese, zvakanyanya isu hatigone kuwana yakakwana PQQ kubva mukudya kwedu kwemazuva ese. Naizvozvo, kana iwe uchida mamwe mabhenefiti akakurisa, unogona kuwana yakawanda yePQQ nedzimwe dzimwe nzira, dzakadai sePQQ yekuwedzera chikafu.

Dheuteronomio:

  • Dhanzi, Kelsey (12 Kukadzi 2017). "Natural Antioxidant Inogona Kudzivirira Chiropa Chirwere". msn.com. Retrieved 14 Kukadzi 2017.
  • Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "Pyrroloquinoline quinone: excretion nemethylotrophs uye kukurudzira kukurudzira kwehutachiona". BioFactors. 1 (1): 51–3. PMID 2855583.
  • Felton LM, Anthony C (2005). "Biochemistry: basa rePQQ semamalia enzyme cofactor?". Zvisikwa. 433 (7025): E10, nhaurirano E11–2. doi: 10.1038 / nature03322. PMID 15689995.
  • Westerling J, Frank J, Duine JA (1979). "Ihwo hwechipfuva hwe methanol dehydrogenase kubva kuHyphomicrobium X: umbozha hwekutenderera hweasronon hunoratidza chimiro che quinone". Biochem Biophys Res Commun. 87 (3): 719–24. doi: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
  • Matsutani M, Yakushi T. Pyrroloquinoline quinone-inotsamira-dehydrogenases yeacetic acid bacteria.Appl Microbiol Biotechnol. 2018 Nov; 102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.

KUGADZIRIRA UYE KUDZIDZA:

Ichi Chinyorwa Kutengeswa Kwekutsvagisa Chete Chete. Mitemo Yekutengesa Nyorera. Kwete Yekushandiswa Kwevanhu, kana Kurapa, Veterinary, kana Kushandisa Kweimba.


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