Pyrroloquinoline quinone (PQQ) (72909-34-3)

March 11, 2019
SKU: 108-09-8

Pyrroloquinoline quinone (PQQ), inonziwo methoxatin, iri redox cofactor. Inowanikwa muvhu uye chikafu senge kiwifruit, se …… ..

 


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

 

Pyrroloquinoline quinone (PQQ) (72909-34-3) vhidhiyo

Pyrroloquinoline quinone (PQQ) (72909-34-3) Nhamba

Product Name Pyrroloquinoline quinone (PQQ)
Kemikari Name Coenzyme PQQ; Methoxatine; Pyrrolo-quinoline quinone;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

CAS Number 72909-34-3
InChIKey MMXZSJMASHPLLR-UHFFFAOYSA-N
kunyemwerera C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
Molecular Formula C14H6N2O8
Molecular Weight 330.21
Monoisotopic Mass 330.012415 g / mol
Boliing Point 1018.6 ± 65.0 ° C (Zvakafanotaurwa)
Flashing point 569.8 ° C (1,057.6 ° F; 842.9 K)
Density 1.963 ± 0.06 g / cm3 (Zvakafanotaurwa)
ruvara Orange-Tsvuku Yakasimba
Kuchengetedza temp 2-8 ° C
Solubility Kusunungura mumvura
kunyoresa PQQ inonzi yakamboshanda senge mumvura inogadziriswa vhitamini / cofactor uye seye antioxidant. Iyo zvakare yakagadzirirwa kushandiswa mune zvekudya zvinowedzera, senge simba, kuchinjiswa pakudya, uye nemabhawa akavakirirwa nezvimwe.

 

Chii Pyrroloquinoline quinone(PQQ)?

Pyrroloquinoline quinone (PQQ), inonziwo methoxatin, ndeye redox cofactor. Inowanikwa muvhu uye chikafu chakadai kiwifruit, pamwe nemukaka wemazamu wevanhu. Pyrroloquinoline quinone ndeye pyrroloquinoline ine mapoka e-oxo ku4 uye mashanu-chinzvimbo uye mapoka e-carboxy pane iyo 5-, 2- uye 7-chinzvimbo. Iyo ine basa sevhitamin-inogadziriswa yemvura uye cofactor. Uye, ndeye chiratidzo chinomiririra mapuroteni kinases inobatanidzwa mukusiyanisa kwemamalia maseru. Iyo yakakwira redox yekudzokorora kugona kwePQQ inogona kuipawo iyo pharmacological basa mukudzivirira kubva kune neurodegeneration uye kenza. (Semunhu anomirira redox, Pyrroloquinoline quinone yakanyatsogadzikana uye inogona kutora mukana mune mamwe mazana maitiro pane mamwe ma antioxidants, akadai ascorbic acid, quercetin, uye epicatechin.

Pyrroloquinoline quinone ingori biofactor, uye yaizivikanwa seye enzyme cofactor mumabhakitiriya. Tsvagurudzo dzinoratidza kuti Pyrroloquinoline quinone inogona kunge iripo munguva yepakutanga yekuzvarwa yekuzvarwa uye kushanduka. Sechikonzero chekukura kwezvirimwa, chiripo mukukura kwemhuka nevanhu. Pyrroloquinoline quinone inonzi inotora chikamu mune dzakasiyana siyana dzebasa rezvipenyu zvine hunhu hwakajeka hwekupona (semuenzaniso, kuvandudzwa kwekukwirirana kwemazano uye kuita kwekubereka) mumhuka.

Uyezve, Pyrroloquinoline quinone ine antioxidant uye B-vitamini-yakafanana nebasa, iine huwandu hwakawanda hwezvinobatsira zvehuropi nemuviri. Iyo inosimudzira hutano hwekuziva uye ndangariro nekurwisa mitochondrial dysfunction uye inochengetedza mauroni kubva mukukuvara kwe-oxidative. Zvidzidzo zvekiriniki muvanhu zvakaratidza kuti Pyrroloquinoline quinone inosimudzira kwenguva pfupi uye nekutarisisa, inovandudza simba metabolism uye kukwegura kune hutano, uye nekudzora mamakisi ekuzvimba, pamwe nekuvandudza manzwiro ekugara zvakanaka.

 

Pyrroloquinoline inoita sei quinone(PQQ) kushanda?

Rat zvidzidzo zvinoratidza kushanda kunoshamisa kwePyrroloquinoline quinone mukusimudzira mitochondrial biogenesis. Rat hepatocytes yakaiswa nePQQ pa10-30 μM ye24-48 h yakaratidza "yakawedzera citrate synthase uye cytochrome c oxidase chiitiko, Mitotracker kusvibisa, mitochondrial DNA zvemukati, uye cellular oxygen kufema. Kuburitswa kwemaitiro aya kwakaitika kuburikidza nekumisikidzwa kweCAMP mhinduro element-inosunga mapuroteni (CREB) uye peroxisome proliferator-activated receptor-γ coactivator-1cy (PGC-1cy), nzira inozivikanwa nekugadzirisa mitochondrial biogenesis. " Mune vivo zvidzidzo mumakonzo zvakare zvinoratidza zvinobatsira kubva mukudya kwekuwedzera nePQQ (2mg PQQ / kg yechikafu). Izvi zvinosanganisira kudzikira kweplasma triglycerides, kuwedzerwa kwesimba kwesimba (kwakabatana ne hepatic mitochondrial zvemukati), uye nekuvandudza kushivirira kune yemoyo ischemia / reperfusion. Ongororo dzemhando dzekurohwa nespinal cord kukuvara dzinoratidza kuti Pyrroloquinoline quinone inoderedza neuronal cell kufa, muchidimbu kuburikidza nePyrroloquinoline quinone inodzivirira N-methyl-d-aspartic acid (NMDA) receptors. Huru mhando dzemhando yechirwere chaParkinson dzinoratidza kuti Pyrroloquinoline quinone yekuwedzera inoderedza kurasikirwa neuronal, inowedzera okisijeni inoshanda yemhando dzekutsvaira kugona, uye inopa kuzvidzivirira kuburikidza nedzimwe nzira.

 

Zvakanakira Pyrroloquinoline quinone(PQQ) inobatsira

Mune uropi nemuviri, PQQ ine zvakawanda zvakasiyana siyana zvinobatsira.

- PQQ inotsigira yakaringana mitochondrial basa

Mitochondria ndivo vanogadzira simba mumaseru edu uye vanoita basa rakakosha muhutano hwedu hwese. PQQ nekudzivirira iripo mitochondria uye inosimudzira chizvarwa chechimochondrial, saka gadzira ATP (Energy). Yakawanda inoshanda mitochondria, isimba rakawanda.

- PQQ inotsigira tsinga kukura zvinhu

PQQ inosimudzira kugadzirwa kweNerve Growth Factor (NGF.), Inochengetedza uye nekudzoreredza maseru neuropi, mabasa, uye kuchengetedzwa kubva pamwoyo uye yemitsipa ischemic zviitiko.

- PQQ inodzivirira kushushikana kweiyo oxidative

PQQ inopa yakasimba antioxidant chengetedzo, inodzivirira masero mumuviri kubva ku oxidative kukuvara uye demage mahara radicals. Iyo inotsigira metabolism yesimba uye hutano hwekukwegura, uye yakafungidzirwa seinori cofactor ine antioxidant uye B vitamini-yakafanana nebasa.

Kunze kwezvo, PQQ inogona kuve nekudzivirira uye kurapa kukuvara kwechiropa uye yakasimba anticancer basa.

Iko kushandiswa / kushandiswa kwe Pyrroloquinoline quinone(PQQ)

Mune chidzidzo che2009 chakaburitswa mupepanhau rekurapa Chinyorwa Chekudya, Pyrroloquinoline Quinone yakaratidzwa kuve neanogona kubatsira kuchengetedza Iyo inoshandiswa kurapa kudzikisira kuderera (kurasikirwa ndangariro, kuoma kwekudzidza, nezvimwewo) nekuda kwezera, kurohwa kana chirwere chemitsipa, uye kuchengetedzwa kubva pamwoyo nemitsipa ischemic zviitiko. Mhedzisiro yakafanana yakataurwa mu 2011 yekutevera kudzidza uko Pyrroloquinoline Quinone yakapihwa zvakananga seyakawedzerwa zvekudya, senge mukaka-unobva pakudya chinwiwa chinwiwa.

 

Nzira yekukwana sei Pyrroloquinoline quinone(PQQ)?

Muhupenyu, unogona kuwana imwe PQQ kubva kune zvimwe zvekudya sourse, zviripo zviripo mune zvakasiyana zvekudya uye zvinwiwa, zvinosanganisira green mhiripiri, parsley, tii kana kiwifruit nezvimwe zvakadaro, kana uchiverenga huwandu hwechikafu chinodyiwa nemunhu mazuva ese, zvakanyanya vedu hatigone kuwana PQQ yakakwana kubva pane zvatinodya zvezuva nezuva. Naizvozvo, kana iwe uchida mamwe mabhenefiti akakura, iwe unogona kuwana yakawanda PQQ nedzimwe nzira, senge PQQ yekuwedzera yekudya.

 

Dheuteronomio:

  • Drain, Kelsey (12 Kukadzi 2017). "Natural Antioxidant Inogona Kudzivirira Chiropa Chirwere". msn.com. Yakadzorerwa 14 Kukadzi 2017.
  • Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "Pyrroloquinoline quinone: excretion nemethylotrophs uye kukurudzira kukurudzira kwehutachiona". BioFactors. 1 (1): 51–3. PMID 2855583.
  • Felton LM, Anthony C (2005). "Biochemistry: basa rePQQ senge mammalian enzyme cofactor?". Zvisikwa. 433 (7025): E10, hurukuro E11–2. doi: 10.1038 / nature03322. PMID 15689995.
  • Westerling J, Frank J, Duine JA (1979). "Boka rekugadzira re methanol dehydrogenase kubva kuHypomicrobium X: electron spin resonance humbowo hwechimiro chequinone" Biochem Biophys Res Commun. 87 (3): 719–24. doi: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
  • Matsutani M, Yakushi T. Pyrroloquinoline quinone-inotsamira-dehydrogenases yeacetic acid bacteria.Appl Microbiol Biotechnol. 2018 Nov; 102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.