Nicotinamide riboside chloride (NR-CL) (23111-00-4)

March 11, 2020

Nicotinamide riboside (NR) ichangobva kuwanikwa nicotinamide adenine dinucleotide (NAD +) inotungamira vhitamini. Iyo …….

 


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

 

Nicotinamide riboside chloride (NR-CL) (23111-00-4) vhidhiyo

Nicotinamide riboside chloride (NR-CL) (23111-00-4) S.pecifications

Product Name Nicotinamide riboside chloride (NR-CL) (23111-00-4)
Kemikari Name NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; Nicotinamide ribose chloride; 3-Carbamoyl-1- (β-D-ribofuranosyl) pyridinium chloride; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride; Nicotinamide BD Riboside Chloride (WX900111); NR-CL;
CAS Number 23111-00-4
InChIKey YABIFCKURFRPPO-IVOJBTPCSA-N
kunyemwerera C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
Molecular Formula C11H15ClN2O5
Molecular Weight 290.7002
Monoisotopic Mass 290.066949 g / mol
Melting Point N / A
ruvara chena
SKuchengetedza temp -20 ° C Freezer
kunyoresa zvekudya zvinowedzera, munda wemishonga

 

Chii Nicotinamide riboside chloride(NR-CL)?

Nicotinamide riboside (NR) ingori ichangobva kuwanikwa nicotinamide adenine dinucleotide (NAD + )amberi vhitamini. Chimiro cheKristalline cheNR chloride chinonzi NIAGEN, chiri chimiro chinogadzira nicotinamide riboside uye kunobva kwainobva iyo nicotinamide muchimiro cheiyo nicotinic acid inogona kuve bioavava uye inowanzoonekwa yakachengeteka (GRAS). NR chloride ndiyo nyaya yezvinyorwa zviviri zvitsva zvemhando yekudya, izvo zvinonyanya kushandiswa muzvikafu zvinowedzera.

Nicotinamide Riboside Chloride chinhu chemusikirwo chinowanikwa mumukaka. Izvo chaizvo zvine chekuita neacin uye mamwe mafomu evitamini B3. Kumwe kutsvagurudza kwakawana kuti Nicotinamide Riboside Chloride ine mamwe maitiro akasarudzika anogona kusimudzira metabolism yemunhu kubatsira kupisa macalorie mazhinji uye kudzivirira kuwedzera huremu. Kunze kwekudzikira uremu, inobatsirawo kuwedzera mhasuru mashandiro, kuwedzera simba rekushandisa, uye kudzikisira njodzi dzinokonzerwa nechirwere cheshuga.

Zvakare, kutsvakwa kwakaitwa muvanhu kwakaratidza kuti zvese zveNicotinamide Riboside Chloride zvinosimudza nhanho dzeNAD, + izvo zvinobatsira kukonzeresa mamwe mamiriro ane hukama nezera, kunyange zvichikurumidza kuziva kuti zvichanyatsoita sei.

 

kubatsira Nicotinamide riboside chloride(NR-CL)

Nicotinamide riboside chloride inzira yekugadzira nicotinamide riboside, mabhenefiti ayo / basa rakafanana nenicotinamide riboside. Iyo inobata mumetabolism mumuviri, inogona kushandiswa kudzivirira pellagra kana imwe niacin yekukanganisa chirwere uye kudzikisa cholesterol uye triglycerides muropa. Inoshandiswa zvakare kudzikisa njodzi yekurwadziwa kwemoyo kune vanhu vane cholesterol yakakura avo vakatove nekurwadziwa kwemoyo. Dzimwe nguva inoshandiswa kurapa coronary artery disease (atherosclerosis), kudzivirira kuchengetedza huropi nechiropa (zvemwoyo, chirwere cheshuga, chirwere cheAlzheimer).

Kunze kwezvo, Nicotinamide riboside chloride inewo zvimwe zvakanaka muvanhu:

  • Kugaya chaipo uye kupinza mapuroteni nemafuta;
  • Batsira kushandura iyo yakakosha amino acid tryptophan mu niacin;
  • Kuderedza kurutsa, uye kuderedza mhedzisiro yekutora antidepressants nekuda kwemuromo wakaoma uye kunetseka kurapa;
  • Kurudzira nicic acid synthesis uye kudzivirira kukwegura kwehutachiona uye nhengo, nekudaro kuzadzisa chinangwa chekunonoka kukwegura;
  • Kunonoka musono mutsipa spasm, kupora mitezo uye ruoko uye tsoka etsoka;
  • Kurapa kweiyogengenism hypometabolism uye kuwedzerwa kwemetabolism;
  • Kudzivirira uye kurapwa kwevhitamini B6 kushomeka;
  • Kurapa kwe carpal tunaki syndrome;
  • Inobatsira kuderedza uremu uye kusimbisa tsandanyama basa.
  • Kuvandudza kurwisa kwemuviri kumasero ekenza
  • Dzivirira kurasikirwa kwekunzwa
  • Ko ndeye diuretiki yepanyama.
  • Kutora yakakura madosi kunogona kudzoreredza zvinodhaka uye kuve neakanaka detoxization athari.
  • Kuvandudza kushanda kwemaseru epermermal, pamwe nemabasa emamwe maseru mumuviri wemunhu, kuti ganda rirambe richiratidzika.

 

Nicotinamide riboside chloride(NR-CL) shandisa

Nekuti Nicotinamide riboside chloride ine mishonga inobatsira, inowanzo shandiswa mune zvekudya zvinowedzera, mushonga uye feedstuff munda.

 

 

Dheuteronomio:

  • Conze D, Brenner C, Kruger CL. Kuchengetedza uye Metabolism yeNguva refu Yekutonga kweNIAGEN (Nicotinamide Riboside Chloride) muRandomized, Double-Blind, Placebo-inodzorwa Clinical Trial yeVatano Vakawanda Vanorema. Sci Rep. 2019 Jul 5; 9 (1): 9772. doi: 10.1038 / s41598-019-46120-z. PMID: 31278280 PMCID: PMC6611812.
  • Bogan, KL, Brenner, C. (2008). "Nicotinic acid, nicotinamide, uye nicotinamide riboside: kuongororwa kwema molecular kweNAD + preursor mavitamini muhutano hwevanhu". Annu. Rev. Nutr. 28: 115-130. doi: 10.1146 / annurev.nutr.28.061807.155443. PMID 18429699.
  • Chi Y, Sauve AA (Mbudzi 2013). "Nicotinamide riboside, inoronda chikafu muzvikafu, vhitamini B3 ine mhedzisiro pasimba metabolism uye neuroprotection". Curr Opin Clin Nutriti Metab Kuchengeta. 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. PMID 24071780.