N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

March 11, 2020
SKU: 146-48-5

NACET (N-Acetylcysteine ​​ethyl ester) inoverengeka lipophilic cell-inobvumidzwa cysteine ​​inogadzirwa neakajairika pharmacokinetic ficha uye inoshamisa… ..

 


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) video

NacET (59587-09-6) Nhamba

Product Name NACET (59587-09-6)
Kemikari Name R) -ethyl 2-acetamido-3-mercaptopropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-ACETYL-L-CYSTEINE ETHYL ESTER
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-Acetylcysteine ​​ethylester;
CAS Number 59587-09-6
InChIKey MSMRAGNKRYVTCX-LURJTMIESA-N
kunyemwerera CCOC (= O) C (CS) NC (= O) C
Molecular Formula C7H13NO3S
Molecular Weight 191.25
Monoisotopic Mass 191.061614 g / mol
Melting Point 44.1-44.5 ° C
Boiling Point  337.6 ± 32.0 ° C (Zvakafanotaurwa)
Density 1.138 ± 0.06 g / cm3 (Zvakafanotaurwa)
ruvara Off-white
kunyoresa Nootropics uye smart zvinodhaka, inogona kushandiswa kuwedzera kukurudzira ndangariro, kutarisa, kusika, kungwara uye kukurudzira. Iyo inogona zvakare kushandiswa seyedzidziso yekuwedzera.

 

Chii NACET(N-Acetylcysteine ​​ethyl ester)?

NACET (N-Acetylcysteine ​​ethyl ester) inoverengeka lipophilic cell-inobvumidzwa cysteine ​​inogadzirwa neakajairwa pharmacokinetic ficha uye inoshamisa antioxidant kugona. NACET ine yakakwira bioavailability yemuromo. Iyo yakasimba antioxidant uye yakapfuma yakatungamira yeGSH, inoenderana neayo yemahara acid N-acetyl -L inosiyana ne -cysteine ​​(NAC). NACET ipfu chena pane tembiricha yemukati uye inosununguka zvakasununguka mumvura uye organic solvents.

NAC chinobva cycyine. Kubva kuma1970s, yanga ichishandiswa kurapa varwere vane acetaminophen overdose neanetsinga yemitsipa, uye inotengeswa semushonga uye nehutano hwekuwedzeredza. Kuenzaniswa neNAC, NACET ine yakakwirira lipophilicity uye yakanyanya kuvandudza epamhepo. Iyo ine mukana wekutsiva pharmacological NAC, seye mucolytic mumiriri, antioxidant, mutengesi weGSH, paracetamol antidote, uye angangove Donor ye gaseous transmitter H 2 S uye UV mumiriri wekudzivirira.

Uye zvakare, iyo yakasimba nucleophilicity uye yekudzora kugona kweNACET yakaratidzawo mumasero matsvuku eropa. Yakawanikwa ichiungana mumasero matsvuku eropa emunhu, zvichinyatso kudzivisa kukuvara kweiyo oxidative kunokonzerwa nehydroperoxides. Naizvozvo, kugona kweNACET seanti-nitrite-inosimudzira antioxidant yakakura kwazvo kupfuura iyo yeNAC methemoglobinemia nemamwe maokisheni akasimba. Zvidzidzo mumakonzo zvakaona kuti NACET inodhonzwa nekukurumidza zvakanyanya kupfuura NAC apo NACET inoitwa nemuromo. Iyo inokwanisa kupinda mumasero uye kugadzira NAC uye cysteine, iyo inowedzera hydrogen sulfide (H (2) S) mukutenderera. Icho mukwikwidzi akanaka wekushandisa pamuromo seye H (2) S mugadziri,

 

Zvakanakira NACET (N-Acetylcysteine ​​ethyl ester)

Seye antioxidant ine simba, NACET ine zvakawanda zvakanaka pahutano hwevanhu.

- Kuvandudza akawanda mamiriro ehutano uye kubvisa zviratidzo zvehurwere hwepfungwa;

- Kurapa kweacetaminophen overdoses, kudzivirirwa kwetsvo uye chiropa;

- Inovandudza mapapu mashandiro kuburikidza nekuderedza kuzvimba uye kupaza marimu, zvichidaro nekuderedza chirwere chisingaperi chekufema.

- Kurudzira hutano hwehuropi nekumisikidza glutamate uye kuwedzera glutathione, inogona kushandiswa kurapa zvirwere zvakaita sechirwere cheAlzheimer uye chirwere chaParkinson;

- Kuvandudza kubereka kwevarume nevakadzi

- Inogona kuvandudza mashandiro ezvirwere mumuviri muzvirwere zvakawanda, kudzivirira kukuvara kweiyo oxidative kumoyo, uye kudzora njodzi yehosha yemoyo.

- Chivabvu Kudzikamisa Ropa Shuga Nekuderedza Kuzvimba muMafuta Maseru

 

Iko kushandira kweNAECT (N-Acetylcysteine ​​ethyl ester)

Nekuti NACET yakaratidza kwakakomba kurwara nepfungwa, chirwere chisingaperi chekufema uye chirwere chepfungwa, inowanzo shandiswa semushonga uye zvekudya zvinowedzera kuchengetedza huropi, kuvandudza kushanda kwepfungwa uye kwemuviri, kuitira kusimudzira ndangariro, kugona uye kuita kwemitambo.

 

Dheuteronomio:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): chinyorwa lipophilic cell-chinobvumirwa cysteine ​​chinobva chisingaenzaniswi chemishonga chemacokinetic chinhu uye chinoshamisa chinogona kurwisa antioxidant. Biochem Pharmacol. 2012 Zvita 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) uye N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine-based-based drug drug anosarudzika nemamwe akasiyana emishonga eprofessor yekushandisa pamuromo saNI, H2S uye GSH vanopa uye as antioxidants: Zvizhinji uye kutarisisa. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Aug 13. Ongorora. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester seye GSH inosimbisa mumasero ekutanga endothelial maseru: Chidzidzo chekufananidza nemimwe mishonga. 2018 Oct; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) uye N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine-yakamisirwa-inomirira zvinodhaka ine yakasarudzika pharmacological profiles yekushandiswa kwemuromo se NO, H2S uye GSH vatengesi uye as antioxidants: Zvizhinji uye kutarisisa. Chinyorwa cheMishonga Kuongorora. Vhoriyamu 8, Nyaya 1, Kukadzi 2018, Mapeji 1-9.