N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

March 11, 2020
SKU: 146-48-5
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NACET (N-Acetylcysteine ​​ethyl ester) inyowani lipophilic cell-inobvumirwa cysteine ​​inobuda neisina kujairika pharmacokinetic chimiro uye zvinoshamisa… ..


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) video

NacET (59587-09-6) Nhamba

Product Name NACET (59587-09-6)
Kemikari Name R) -ethyl 2-acetamido-3-mercaptopropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-ACETYL-L-CYSTEINE ETHYL ESTER;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-Acetylcysteine ​​ethylester;
CAS Number 59587-09-6
InChIKey MSMRAGNKRYVTCX-LURJTMIESA-N
kunyemwerera CCOC (= O) C (CS) NC (= O) C
Molecular Formula C7H13NO3S
Molecular Weight 191.25
Monoisotopic Mass 191.061614 g / mol
Melting Point 44.1-44.5 ° C
Boiling Point 337.6 ± 32.0 ° C (Zvakafanotaurwa)
Density 1.138 ± 0.06 g / cm3 (Zvakafanotaurwa)
ruvara Off-white
kunyoresa Nootropics uye smart zvinodhaka, inogona kushandiswa kuwedzera kukurudzira ndangariro, kutarisa, kusika, kungwara uye kukurudzira. Iyo inogona zvakare kushandiswa seyedzidziso yekuwedzera.

Chii NACET(N-Acetylcysteine ​​ethyl ester)?

NACET (N-Acetylcysteine ​​ethyl ester) inyowani lipophilic cell-inobvumirwa cysteine ​​inobuda neisina kujairika pharmacokinetic ficha uye inoshamisa antioxidant mukana. NACET ine yakakwira yomuromo bioavailability. Iyo yakasimba antioxidant uye yakapfuma preursor yeGSH, ine hukama neiyo yemahara acid N-acetyl -L inosiyana -cysteine ​​(NAC). NACET yakachena poda pamhepo tembiricha uye inosungunuka zvakasununguka mumvura uye organic sol sol.

NAC chinobva cycyine. Kubva kuma1970s, yanga ichishandiswa kurapa varwere vane acetaminophen overdose neanetsinga yemitsipa, uye inotengeswa semushonga uye nehutano hwekuwedzeredza. Kuenzaniswa neNAC, NACET ine yakakwirira lipophilicity uye yakanyanya kuvandudza epamhepo. Iyo ine mukana wekutsiva pharmacological NAC, seye mucolytic mumiriri, antioxidant, mutengesi weGSH, paracetamol antidote, uye angangove Donor ye gaseous transmitter H 2 S uye UV mumiriri wekudzivirira.

Mukuwedzera, iyo yakasimba nucleophilicity uye kuderedza mukana weNACET yakaratidzirwawo mumasero matsvuku eropa emunhu. Yakawanikwa kuunganidzira mumasero matsvuku eropa emunhu, zvichinyatso kurwisa oxidative kukuvara kunokonzerwa ne hydroperoxides. Naizvozvo, kugona kweNACET senge anti-nitrite-indened antioxidant kwakakura kudarika iko kweNAC methemoglobinemia uye mamwe maoxidant akasimba. Zvidzidzo mumakonzo zvakaona kuti NACET inobatwa nekukurumidza zvakanyanya kupfuura iyo NACET painotumirwa nemuromo. Inokwanisa kupinda mumasero uye inogadzira NAC uye cysteine, iyo inowedzera hydrogen sulfide (H (2) S) mukutenderera. Iyo yakanaka inomirira yekushandisa pamuromo seye H (2) S inogadzira,

Zvakanakira NACET (N-Acetylcysteine ​​ethyl ester)

Seye antioxidant ine simba, NACET ine zvakawanda zvakanaka pahutano hwevanhu.

- Kuvandudza hutano hwakawanda mamiriro uye kuderedza zviratidzo zvechirwere chepfungwa;

- Kurapa acetaminophen overdoses, kuchengetedzwa kweitsvo uye chiropa;

- Inovandudza basa remapapu nekuderedza kuzvimba nekuputsa mamosi, nekudaro ichideredza chirwere chisingaperi chekufema.

-Kusimudzira hutano hwehuropi kuburikidza nekutarisa glutamate uye kuwedzera glutathione, inogona kushandiswa kurapa zvirwere zvakadai sechirwere cheAlzheimer uye chirwere cheParkinson;

- Kuvandudza kubereka muvarume nevakadzi

- Inogona kuvandudza immune immune muzvirwere zvakawanda, kudzivirira oxidative kukuvara kwemoyo, uye kuderedza njodzi yechirwere chemoyo.

-Mai Simbisai Ropa Shuwa Nekudzikisira Kuzvimba Kwemafuta mune Masero

Iko kushandira kweNAECT (N-Acetylcysteine ​​ethyl ester)

Nekuti NACET yakaratidza zvakakomba pakurwara kwepfungwa, chirwere chisingaperi chekufema uye chirwere chepfungwa, chinowanzoshandiswa semushonga uye chekudya chinowedzera kuchengetedza uropi, kugadzirisa pfungwa nemuviri, kuitira kuti uwedzere kuyeuka, kuziva uye kuita zvemitambo.

Dheuteronomio:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): chinyorwa lipophilic cell-chinobvumirwa cysteine ​​chinobva chisingaenzaniswi chemishonga chemacokinetic chinhu uye chinoshamisa chinogona kurwisa antioxidant. Biochem Pharmacol. 2012 Zvita 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) uye N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine-based-based drug drug anosarudzika nemamwe akasiyana emishonga eprofessor yekushandisa pamuromo saNI, H2S uye GSH vanopa uye as antioxidants: Zvizhinji uye kutarisisa. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Aug 13. Ongorora. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester seye GSH inosimbisa mumasero ekutanga endothelial maseru: Chidzidzo chekufananidza nemimwe mishonga. 2018 Oct; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) uye N-acetyl-L-cysteine ​​ethyl ester (NACET) -Cysteine-yakamisirwa-inomirira zvinodhaka ine yakasarudzika pharmacological profiles yekushandiswa kwemuromo se NO, H2S uye GSH vatengesi uye as antioxidants: Zvizhinji uye kutarisisa. Chinyorwa cheMishonga Kuongorora. Vhoriyamu 8, Nyaya 1, Kukadzi 2018, Mapeji 1-9.