NADP disodium munyu (24292-60-2)

March 15, 2020
SKU: 164656-23-9
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Nicotinamide adenine dinucleotide phosphate (NADP +) ndeye cofactor inoshandiswa mune anabolic reaction. β -Nicotinamide adenine ……


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

NADP disodium munyu (24292-60-2) vhidhiyo

β-Nicotinamide adenine dinucleotide phosphate disodium munyu (NADP disodium munyu) Specifications

Product Name β-Nicotinamide adenine dinucleotide phosphate disodium munyu (NADP disodium munyu)
Kemikari Name NADP Disodium; Nadide phosphate disodium; NADP; β-NADP; Triphosphopyridine nucleotide disodium munyu;
CAS Number 24292-60-2
InChIKey UNRRSQIQTVFDLS-WUEGHLCSSA-L
kunyemwerera C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+]
Molecular Formula C21H26N7Na2O17P3
Molecular Weight 787.37
Monoisotopic Mass 787.039342 g / mol
Melting Point 175-178 ° C
ruvara Yero
Storage temp -20 ° C
Mvura Solubility > 50 g / L
kunyoresa Coenzyme mune aerobic uye anaerobic oxidations

Chii chinonzi β-Nicotinamide adenine dinucleotide phosphate disodium munyu (NADP disodium munyu)?

Nicotinamide adenine dinucleotide phosphate (NADP +) ndeye cofactor inoshandiswa mune anabolic reaction. β-Nicotinamide adenine dinucleotide phosphate disodium munyu ndi disodium munyu weNADP +, iri coenzyme inodiwa kune iyo doro kufashaira kweglucose uye oxidative dehydrogenation yezvimwe zvinhu. Uye zvinoitika zvakawandisa mumatehwe anorarama, kunyanya muchiropa.

Nicotinamide adenine dinucleotide phosphate (NADP) uye NADPH vanoumba redox joiri. Iyo NADPH / NADP chiyero inogadzirisa intracellular redox inogona, kunyanya kupindura anaerobic, nekudaro inokanganisa mhinduro yemetabolism mumuviri. Mienzaniso ndeye lipid uye nucleic acid synthesis. NADP zvakare iri coenzyme vaviri mune dzakasiyana cytochrome P450 masisitimu uye oxidase / reductase reaction system senge thioredoxin reductase / thioredoxin system.

NADPH inopa kuderedza yakafanana neye biosynthetic reaction uye inopa redox mhedzisiro kudzivirira kutapira kweiyo inoshanda oksijeni marudzi (ROS), nekudaro kuvandudza glutathione (GSH). Iyo inoshandiswawo mu anabolic nzira dzakadai senge cholesterol synthesis uye mafuta acids Chain kuwedzera

Uye zvakare, iyo NADPH system inoitawo basa rekugadzira mahara radicals mumasoja emuviri kuburikidza neNADPH oxidase. Aya emahara radicals anoshandiswa kuparadza hutachiona muchirongwa chinonzi kufema kuputika. Iyo inoderedza yakaenzana neiyo sosi cytochrome P450 hydroxylated aromatics, steroid, alcohols, uye zvinodhaka.

kunyoresa of β-Nicotinamide adenine dinucleotide phosphate disodium munyu

Nicotinamide adenine dinucleotide phosphate (NADP) uye NADPH vanoumba redox joiri. NADP / NADPH iri coenzyme inotsigira maitiro e redox kuburikidza nekufambisa kwemagetsi mune akawanda matanho ekushandisa, kunyanya anaerobic maitiro akadai lipid uye syntic acid synthesis. NADP / NADPH ndeyavakabatana coenzyme mune akasiyana cytochrome P450 masisitimu uye oxidase / reductase reaction system, senge thioredoxin reductase / thioredoxin system.

Mamwe ma enzymes anoshandisa NADP se coenzyme ndeizvi: Doro dehydrogenase: NADP inotsamira; Aromatic ADH: NADP inotsamira; Ffereoxin-NADP reductase; L-Fucose dehydrogenase; Gabase; Galactose-1-phosphate uridyl yekubvisa; Glucose dehydrogenase; L-Glutamic dehydrogenase; Glycerol dehydrogenase: NADP chaiyo; Isocitric dehydrogenase; Malic enzymes; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase uye Succinic semialdehyde dehydrogenase.

Dheuteronomio:

  • Hashida SN, Kawai-Yamada M. Inter-Organelle NAD Metabolism Inotsigira Chiedza Inoterera NADP Dynamics muZvirimwa. Mberi Dzviti Sci. 2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
  • Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. Iyo tuberculosis necrotizing toxin an NAD + uye NADP + glycohydrolase ine akasiyana enzymatic zvivakwa.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
  • Liang J, Huang H, Wang S. Distribution, Evolution, Catalytic Mechanism, uye Physiological Function yeFlavin-Yakavakirwa Electron-Bifurcating NADH-Dependent Yakaderedzwa Ffereoxin: NADP + Oxidoreductase. Pamberi Microbiol. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
  • Kawai S, Murata K. "Dhizaini uye basa reNAD ​​kinase uye NADP phosphatase: kiyi enzymes inotonga iyo intracellular chiyero cheNAD (H) uye NADP (H)". Bioscience, Biotechnology, uye Biochemistry. 72 (4): 919–30. doi: 10.1271 / bbb.70738. PMID 18391451.
  • Hanukoglu I. "Kuchengetedza kweiyo Enzyme-Coenzyme Interfaces muFAD neNADP Kusunga Adrenodoxin Kuderedza-A Ubiquitous Enzyme". Chinyorwa cheMoleky Evolution. 85 (5-6): 205–218. Bibcode: 2017JMolE..85..205H. doi: 10.1007 / s00239-017-9821-9.PMID 29177972.