Oleoylethanolamide (OEA) (111-58-0)

March 11, 2020
SKU: 16589-24-5
5.00 kupererwa ne 5 maererano ne 1 kasitoma Rating

Oleoylethanolamide (OEA) is endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Icho chiri …………… ..


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

Oleoylethanolamide (OEA) (111-58-0) vhidhiyo

Oleoylethanolamide (OEA) (111-58-0) Nhamba

Product Name Oleoylethanolamide (OEA) hupfu
Kemikari Name n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Number 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
kunyemwerera CCCCCCCCC = CCCCCCCCC (= O) NCCO
Molecular Formula C20H39NO2
Molecular Weight 325.5 g / mol
Monoisotopic Mass 325.537 g · mol-1
Melting Point 59-60 ° C (138-140 ° F; 332-333 K)
Boiling Point 496.4 ± 38.0 ° C (Zvakafanotaurwa)
Density 0.915 ± 0.06 g / cm3 (Zvakafanotaurwa)
ruvara White powder
Storage temp -20 ° C
Solubility mu ethanol uye DMSO Soluble
kunyoresa Phamaceutical munda; supplments;

tsananguro

Oleoylethanolamide (OEA) kana N-Oleoylethanolamide (OEA) imoremo inogadzirwa mumuviri, inowanzowanikwa mumatumbo. Kuwedzera humboo hunoratidza kuti OEA inogona kuita sechinhu endo native neuroprotective chinhu uye kutora chikamu mukudzora maitiro anoenderana nemubayiro. Zvakare, yakarondedzerwa seinopedza kuita seyakagadziriswa inoderedza kudya nekudya kwemuviri.

Chii chinonzi Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) is endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Ichi chiitiko chinongoitika glycolamide lipid ine akasiyana eakasarudzika homeostasis midziyo senge yekuda kudya, yekudzivirira-kuita basa, kukurudzira kwe lipolysis uye mafuta acid oxidation. Oleoylethanolamide inogona kutorwa sehomoni yemudumbu uropi axis. Oatmeal, nzungu, uye cocoa poda ndizvo zvikuru zvekudya zveOleoylethanolamide mukudya. Nekudaro, iyo huwandu hweOleoylethanolamide inowanikwa mune izvi zvikafu yakaderera (ishoma kupfuura 2 µg / g).

Seye biological inoshanda lipid svikiro, oleylethanolamide (OEA) inogadzirwa mudumbu uye nemamwe matishu, uye inobatanidzwa mumamalian simba chiyero mutemo, kutonga chikafu chekudya uye lipid metabolism, senge iyo inogona kutonga Vertebrate chikafu uye uremu hwemuviri. Oleoylethanolamide is fatty acid ethanolamide (FAE), monounsaturated analog ye endocannabinoid arachidonic acid ethanolamide (anandamide), uye inoshanda antagonist ye anandamide. Izvo zvakakosha kutarisa kuti Oleoylethanolamide yakasiyana neye anandamide, iyo yakazvimirira ye cannabinoid receptor, uye inobata basa rayo rekubereka kuburikidza nedzimwe nzira, inorongedza basa rePPAR-α kukurudzira lipolysis. Oleoylethanolamide mushonga unokwanisa uye wakachengeteka wekurwisa-kufutisa unotsiva CB1 kupesana.

Ongororo preclinical yakaratidza kuti Oleoylethanolamide iriwo inoshanda inorwisa-kutapudza uye antioxidant potasi iyo inoburitsa mitsipa yenyonganiso mukudhakwa. Exo native management yeOleoylethanolamide inogona kudzivirira zvinobudirira doro-yakanyungududza TLR4-yakatemerwa proinflammatory cascades, nekudaro ichideredza kubudiswa kwe proinfigueatory cytokines uye chemokines, oxidative uye nitrosative kusagadzikana, uye pakupedzisira inodzivirira kukanganisika kwemutsipa kumberi cortex yemakonzo.

Source of Oleoylethanolamide (OEA)

Iko kune maviri masosi ekutora Oleoylethanolamide (OEA), imwe ndeyavo kubva kune zvakasikwa zvidyarwa, uye imwe yacho yakaumbwa zvakanyatsogadzirirwa mu lab.

Achyranthes Aspera, akaberekerwa kuIndia, China nedzimwe nyika zhinji dzeAsia, anonzi ane Oleoylethanolamide OEA. Dambudziko reiyo yakasikwa-yakagadzirirwa Oleoylethanolamide ndeyekuti pane chikamu chega chega chinowanika, 15: 1 yakakurumbira spec, uye haina simba sekutarisirwa kwevatengi kana vatengi vekuwedzera. Ehe, inogona kuve yakakwira, asi mutengo unenge wakanyanyisa, nekudaro hazvisi zvakadaro kugadzira zvakasikwa Oleoylethanolamide OEA yakawanda.

Nzvimbo huru yeOleoylethanolamide yakagadzirwa kubva kune oleic acid, yakashanda seyamberi yeN-oleoyl-phosphatidylethanolamine, iyo ipapo inojekeswa neN-acyl-phosphatidylethanolamine-inosarudza phospholipase D (PLD) kusunungura Oleoylethanolamide OEA.

Oleoylethanolamide ndeye yakasikwa metabolite yealeic acid. Naizvozvo, zvikafu zvinokanganisa oleic acid ndiyo yakananga sosi yeOEA.

Ko Oleoylethanolamide (OEA) anoshanda sei?

Mune vanhu vanoneta, OEA inogona kudzora simba homeostasis uye kudya kunonyanya kuita nekumiswa kwema receptor akasiyana anosanganisira proximal proliferator-activated receptor-α (PPAR-α), G-protein-yakabatanidzwa receptor 119 (GPR119) uye inononoka receptor inogona cation chiteshi pasi peV (TRPV1). Chokwadi, OEA inomutsa idzi receptors uye kunonoka kutanga kudya, kuderedza kukura kwehupfu, kuderedza kupindirana pakati pekudya uye pakupedzisira kunogadzirisa uremu.

Zvakare, kumwe kuongorora kwakaratidza kunoratidza kuti OEA inodzvinyirira kutaura kwe IL-6, interleukin-8 (IL-8), interellular adhesion molecule-1 (ICAM-1) uye vascular cell adhesion molecule-1 (VCAM-1) muTNF -Ikunyepedzera kuzvimba mukati mevanhu umbilical vein endothelial masero kuburikidza nekuvhiya kweanoporesa vanogamuchira. OEA zvakare yakavharidzira iyo nyukiliya factor kappa-B (NF-kB) nzira mumuviri. Muongororo yeYT et al, OEA (50 µmol / L) yakadzivirira iyo TNF-α inokurudzira VCAM-1 kutaura kuHUVEC.

Zvakanakira Oleoylethanolamide (OEA)

Oleoylethanolamide (OEA) poda yakanaka kuderedza uremu senge kudya kwemamongi uye kunotsigira hutano cholesterol mazinga muvakuru.

Oleoylethanolamide (OEA) seanodzvinyirira Appetite

Kudzvanyirira chishuvo uye nokudaro kuderedza kudya kwekudya inzira inoshanda yekudzora zvese simba chiyero uye uremu hwemuviri. Sezvo chishuvo chekudzvinyirira chakanyanya kudzora nzvimbo yesimba (chikafu) kudya, kubata chishuvo kwakakosha mukudzora huremu hwemuviri, kunyanya kana hwakasanganiswa nehutano hwekuziva mararamiro akasarudzika ayo anosanganisira kutarisira kudya kwakakodzera kwekudya, kuwedzeredza kwekudya, uye kurovedzera muviri.

Oleoylethanolamide inowedzera inobatsira kudzora lipid metabolism, inobatsira kudzora nzara nekutumira manzwi ekuwedzera ekutya kuhuropi uye yakaratidzwa kubatsira kubatsira kudzikisa zvese zviri zviviri triglyceride uye neropa cholesterol mazinga.

Oleoylethanolamide yeMutungamiriri wemafuta mafuta

OEA inzira yakachengeteka yemagetsi inodzora chishuwo uye kushandiswa kwemagetsi.

Mhedzisiro yeOEA yakatanga kudzidza nekuti inogovana zvakafanana neimwe kemikari, cannabinoid inozivikanwa se anandamide. Cannabinoids ine hukama nechirimwa Cannabis, uye anandamides aripo muchirimwa (uye mbanje) inogona kuwedzera munhu chishuvo chekumanikidza nekukonzera mhinduro yekudyisa. Maererano neWikipedia, Oleoylethanolamide ndiyo monounsaturated analogue ye endocannabinoid anandamide. Kunyangwe OEA ine chimiro chemakemikari chakafanana ne anandamide, mhedzisiro yayo pakudya uye kurema manejimendi akasiyana. Kusiyana ne anandamide, OEA inoita yakazvimirira ye cannabinoid nzira, inorongedza basa rePPAR-α kukurudzira lipolysis.

Oleoylethanolamide kuvaka muviri

Wese munhu anotsvaga hutano kuburikidza nekuvaka muviri mumuviri. OEA inowedzera kuve inozivikanwa kune vanovaka muviri. Muminda inovaka muviri, TTA (tetradecylthioacetic acid) inowanzo synergistically inoshandiswa nealeoylethanolamide (OEA), ese ari maviri anobatsira kupisa mafuta uye kuderedza nzara. TTA inogonawo kunge iri kuvimbisa zvikuru pakati peanopikisa-mafuta ma supplements, nekuti inoita kunge ichipisa mafuta akazvimiririra pakurovedza muviri; zvekutanga zvinoratidza kuti muviri unongoratidzika "kubvisa" mafuta pachawo pachinzvimbo chekuda kuti utsve nemabasa emuviri.

Oleoylethanolamide (OEA) inoderedza triglycerides uye cholesterol, uye, pamwe necannabinoid antagonist, inovhara uremu hwemuviri kuwana uye inovandudza dyslipidaemia mune mhuka mhuka dzekufutisa.

Uye zvakare, iyo systemic management ye oleoylethanolamide yakawanikwa kuti igadzirise glucose homeostasis, pamwe nekuburitsa insulini uye insulin kuratidza mune ese hepatocytes uye adipocytes.

Mamwezve rereearch anoratidza kuti oleoylethanolamide inowedzera ine maitiro akanaka pane kunetseka, uye yakawanda nzira uye humbowo hunodiwa kuti utsigire.

Mashandisiro aungaitwa Oleoylethanolamide OEA

Oleoylethanolamide mhedzisiro

Oleoylethanolamide OEA iri hutsva kumusika wekuwedzera, uye hapana chakakomba mhedzisiro chakataurwa. Iyo US Food and Drug Administration (FDA) yakanga isinei nezvekuchengeteka kweOEA. Muhupenyu hwezuva nezuva, oleoylethanolamide yakachengeteka uremu kurasikirwa neimwe nzira, iyo inoshandiswa kuongorora huwandu hwe catabolism mune gastro-mudumbu turakiti, kubatsira kuderedza mafuta pasina zvinokuvadza zvisina kufanira migumisiro.

Oleoylethanolamide muyero

Iko hakuna inokurudzirwa pachena dosage ye oleoylethanolamide sezvo oleoylethanolamide supplements haisati yakakurumbira uye panguva yayo yekutanga. RiduZone yaive yekutanga OEA powder kuve yakaiswa chiratidzo muna 2015.

Iyo yakakurudzirwa oleoylethanolamide dosage imwe kapeturu 200mg kana inotorwa pasina musanganiswa

Tsvagudzo inoratidza kuti iwe unogona zvakare kuderedza kana kuwedzera zuva nezuva dosage zvinoenderana nehuremu hwako.

100mg yemunhu 150lb

145mg yemunhu 200lb

180mg yemunhu 250lb

Kushandiswa kweOleoylethanolamide (OEA)

Oleoylethanolamide poda yakashandisa muhutano hwekuwedzeredza, inogadzirwa muHard kapisule kana piritsi rehuremu.

Dheuteronomio:

  • Gaetani S, Oveisi F, Piomelli D (2003). "Modction yeupfu hwekudya mune iyo rat neye anoretic lipid muenzanisi oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.

  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Mirairo yezvikafu zvinowanikwa ne oleoylethanolamine". Sero. Mol. Hupenyu Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.

  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniani Piomelli (2005-12-22). "Postprandial kuwedzera kwe oleoylethanolamine kusimudzira mudiki mudumbu reBurmese python (Python molurus)". Ndiri J Physiol Regul Kubatanidza Comp Physiol. 290 (5): R1407-R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.

  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Gunyana 2008). "Basa re endocannabinoids nemafananidziro avo mukufutisa uye matambudziko ekudya". Kudya Kurema Kurema. 13 (3): e42-8. PMID 19011363.

  • Serrano A, et al. Oleoylethanolamide: mhedzisiro pa hypothalamic transmitters uye matumbu peptides anogadzirisa kudya kwekudya. Neuropharmacology. (2011)