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Oleoylethanolamide (OEA) (111-58-0)

Oleoylethanolamide (OEA) is endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Icho chiri …………… ..


Mamiriro: MuMitambo Yokugadzira
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Oleoylethanolamide (OEA) (111-58-0) Nhamba

Product Name Oleoylethanolamide (OEA)
Kemikari Name n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

CAS Number 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
kunyemwerera CCCCCCCCC = CCCCCCCCC (= O) NCCO
Molecular Formula C20H39NO2
Molecular Weight 325.5 g / mol
Monoisotopic Mass 325.537 g · mol-1
Melting Point 59-60 ° C (138-140 ° F; 332-333 K)
Boiling Point 496.4 ± 38.0 ° C (Zvakafanotaurwa)
Density 0.915 ± 0.06 g / cm3 (Zvakafanotaurwa)
ruvara Chena
Storage temp -20 ° C
Solubility mu ethanol uye DMSO Soluble
kunyoresa Phamaceutical munda; supplments;

Chii chinonzi Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) is endo native peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. Ichi chiitiko chinongoitika glycolamide lipid ine akasiyana eakasarudzika homeostasis midziyo senge yekuda kudya, yekudzivirira-kuita basa, kukurudzira kwe lipolysis uye mafuta acid oxidation. Oleoylethanolamide inogona kutorwa sehomoni yemudumbu uropi axis. Oatmeal, nzungu, uye cocoa poda ndizvo zvikuru zvekudya zveOleoylethanolamide mukudya. Nekudaro, iyo huwandu hweOleoylethanolamide inowanikwa mune izvi zvikafu yakaderera (ishoma kupfuura 2 µg / g).

Seye biological inoshanda lipid svikiro, oleylethanolamide (OEA) inogadzirwa mudumbu uye nemamwe matishu, uye inobatanidzwa mumamalian simba chiyero mutemo, kutonga chikafu chekudya uye lipid metabolism, senge iyo inogona kutonga Vertebrate chikafu uye uremu hwemuviri. Oleoylethanolamide is fatty acid ethanolamide (FAE), monounsaturated analog ye endocannabinoid arachidonic acid ethanolamide (anandamide), uye inoshanda antagonist ye anandamide. Izvo zvakakosha kutarisa kuti Oleoylethanolamide yakasiyana neye anandamide, iyo yakazvimirira ye cannabinoid receptor, uye inobata basa rayo rekubereka kuburikidza nedzimwe nzira, inorongedza basa rePPAR-α kukurudzira lipolysis. Oleoylethanolamide mushonga unokwanisa uye wakachengeteka wekurwisa-kufutisa unotsiva CB1 kupesana.

Ongororo preclinical yakaratidza kuti Oleoylethanolamide iriwo inoshanda inorwisa-kutapudza uye antioxidant potasi iyo inoburitsa mitsipa yenyonganiso mukudhakwa. Exo native management yeOleoylethanolamide inogona kudzivirira zvinobudirira doro-yakanyungududza TLR4-yakatemerwa proinflammatory cascades, nekudaro ichideredza kubudiswa kwe proinfigueatory cytokines uye chemokines, oxidative uye nitrosative kusagadzikana, uye pakupedzisira inodzivirira kukanganisika kwemutsipa kumberi cortex yemakonzo.

Chii chinonzi Oleoylethanolamide (OEA) chinoshanda?

Mune vanhu vanoneta, OEA inogona kudzora simba homeostasis uye kudya kunonyanya kuita nekumiswa kwema receptor akasiyana anosanganisira proximal proliferator-activated receptor-α (PPAR-α), G-protein-yakabatanidzwa receptor 119 (GPR119) uye inononoka receptor inogona cation chiteshi pasi peV (TRPV1). Chokwadi, OEA inomutsa idzi receptors uye kunonoka kutanga kudya, kuderedza kukura kwehupfu, kuderedza kupindirana pakati pekudya uye pakupedzisira kunogadzirisa uremu.

Zvakare, kumwe kuongorora kwakaratidza kunoratidza kuti OEA inodzvinyirira kutaura kwe IL-6, interleukin-8 (IL-8), interellular adhesion molecule-1 (ICAM-1) uye vascular cell adhesion molecule-1 (VCAM-1) muTNF -Ikunyepedzera kuzvimba mukati mevanhu umbilical vein endothelial masero kuburikidza nekuvhiya kweanoporesa vanogamuchira. OEA zvakare yakavharidzira iyo nyukiliya factor kappa-B (NF-kB) nzira mumuviri. Muongororo yeYT et al, OEA (50 µmol / L) yakadzivirira iyo TNF-α inokurudzira VCAM-1 kutaura kuHUVEC.

Zvakanakira Oleoylethanolamide (OEA)

Sezvo ceramidase inhibitor, endo native agonist yeGPR119 receptor, Oleoylethanolamide inoshanda kurwisa neurodegenerative chirwere, anti-atherosclerosis, apoptosis, kurwadziwa kusunungurwa, yakawedzera lipid metabolism, uye masero pane islet β masero. Dziviriro uye zvimwe zvirwere zve metabolic zvine yakanaka yekudzivirira maitiro. Mukuwedzera, inogona kuderedza mafuta emuviri nekudzora chishuwo, kudzora uremu, uye kuwana uremu. Oleoylethanolamide zvakare ine kugona kuderedza kuzvimba uye kuderera cholesterol mazinga.

Iko kushandiswa kweOleoylethanolamide (OEA)

  • Phamaceutical munda Dhivhara supplments
  • Gaetani S, Oveisi F, Piomelli D (2003). "Modction yeupfu hwekudya mune iyo rat neye anoretic lipid muenzanisi oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Mirairo yezvikafu zvinowanikwa ne oleoylethanolamine". Sero. Mol. Hupenyu Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniani Piomelli (2005-12-22). "Postprandial kuwedzera kwe oleoylethanolamine kusimudzira mudiki mudumbu reBurmese python (Python molurus)". Ndiri J Physiol Regul Kubatanidza Comp Physiol. 290 (5): R1407-R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.
  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (Gunyana 2008). "Basa re endocannabinoids nemafananidziro avo mukufutisa uye matambudziko ekudya". Kudya Kurema Kurema. 13 (3): e42-8. PMID 19011363.
  • Serrano A, et al. Oleoylethanolamide: mhedzisiro pa hypothalamic transmitters uye matumbu peptides anogadzirisa kudya kwekudya. Neuropharmacology. (2011)

KUGADZIRIRA UYE KUDZIDZA:

Ichi Chinyorwa Kutengeswa Kwekutsvagisa Chete Chete. Mitemo Yekutengesa Nyorera. Kwete Yekushandiswa Kwevanhu, kana Kurapa, Veterinary, kana Kushandisa Kweimba.


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