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Ganglioside GT1b (59247-13-1)

Ganglioside yakatanga kushandiswa nesainzi yekuGerman Ernst Klenk muna 1942 kuenda kumaipids achangobva kubuda kubva muuropi ganglion cell… ..


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

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Ganglioside GT1b Specifications

Product Name Ganglioside GT1b
Kemikari Name GANGLIOSIDE GT1B TRISODIUM SALT; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + SALT); ganglioside, gt1; (ganglioside gt1B) kubva kune bovine brain; trisialoganglioside-gt1b kubva bovine uropi; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + munyu)
CAS Number 59247-13-1
InChIKey SDFCIPGOAFIMPG-VLTFPFDUSA-N
Molecular Formula C95H162N5Na3O47
Molecular Weight 2158.4 g / mol
Monoisotopic Mass 2157.119189 g / mol
Melting Point N / A
Storage temp -20 ° C
Solubility DMSO: inosungunuka
kunyoresa Mushonga; chromatography;

Chii Ganglioside GT1b?

Iri zita Ganglioside rakatanga kushandiswa nesainzi yekuGerman Ernst Klenk muna 1942 kuenda kuma lipids achangobva kubuda kubva kuuropi ganglion cell. Iyo molekyumu inosanganiswa ne glycosphingolipids (ceramides uye oligosaccharides) uye imwe chete kana kupfuura sialic acids akabatana necheni ye shuga. Icho chikamu che cytoplasmic membrane iyo inorongedza ma cellular sign transduction zviitiko. Anopfuura makumi matanhatu emhando dze gangliosides anozivikanwa, uye musiyano mukuru pakati pawo chinzvimbo nenhamba yenzvimbo dzeNANA zvasara.

Ganglioside GT1b ndeimwe yemazhinji ganglioside uye ndeye trisialic ganglioside ine maviri asalic acid maseru akabatana neyemukati galactose unit. Iyo ine inhibitory maitiro pamuviri wekunyadzisa immune immune. Pa0.1 μM, inogona kutadzisa kugadzirwa kwemukati kweIgG, IgM uye IgA nemasero eropa remunhu. Ganglioside GT10b yakawirirwawo seyekugamuchira cell receptor ye Merkel cell polyoma hutachiona uye senzira inokwanisa kukonzeresa hutachiona hunokonzera Merkel cell carcinoma

Ganglioside GT1b zvakare yakaverengerwa mune akati wandei maroni cancers uye inoonekwa seimwe ganglioside ine chekuita nehuropi metastases. Zvidzidzo zvakawana kuti GM1, GD1a, uye GT1b zvine inhibitory mhedzisiro pane epadermal kukura factor receptor kusaina uye kuomerera uye kutama kwe keratinocyte, uye kuvapo kwavo kunogona kunge kuri biomarker inobatsira yekuongorora uropi metastatic kugona.

Ganglioside GT1b inokanganisawo immune system. Ganglioside GT1b ine inhibitory mhedzisiro pane humity immune system yekudzivirira kwemuviri uye inhibits immunoglobulins inogadzirwa nevanhu veparodzi yeropa mononuclear maseru. Pane humbowo hwekuti GD1b, GT1b, uye GQ1b inogona kukwidziridza kugadzirwa kweT1 cytokines nekukanganisa basa re adenylate cyclase, apo ichitadzisa kugadzirwa kweT2.

Se receptor iyo inocherekedza akasiyana-siyana masikisi eiyo oligosaccharide chimiro, ganglioside GT1b is receptor kuburikidza neiyo Clostridium botulinum bacterium botulinum neurotoxin inopinda nerve masero. Zvidzidzo zvakaratidza kuti tetanus toxin inopinda mutsinga dzeseroma nekudzvanya neGT1b nemamwe magenge, inokanganisa kuburitswa kwema neurotransmitters ari mukati mehusope system, uye ichikonzera kuora mitezo. Iyo botulinum yemhando C neurotoxin inopinda mutsinga yakaongorora maitiro angangoita apoptotic yemaseru anogadzirwa ganglioside GT1b inosunga pane neuroblastoma.

Uye zvakare, ganglioside GT1b inodzora zvisiri izvo kufamba kwemasero, kusanganisa, uye kuomerera kune fibronectin (FN) kuburikidza nekunangana zvakananga nemoporosiyumu ne cy5 subunit ye ​​α5β1 inclin, kutsvaga kunogona kushandiswa kuvandudza marapirwo echirwere chegomarara. Iko kusanganiswa kweGT1b uye MAG pamusoro pematonon kunogona kukonzeresa kudyidzana kweGT1b mucous membrane yemuroni, zvichikonzera kudzivirira kwekukura kwema neurite.

Zvakanakira Ganglioside GT1b

Ganglioside GT1b is acidic glycosphingolipid iyo inoumba lipid rafts mumukati memasero eonstatic system uye inobatanidzwa mukuwedzeredza kwemasero, mutsauko, kuomerera, chiratidzo chechiratidzo, kupindirana-kwesero-cell, tumorigenesis, uye metastasis.

Autoimmune mhinduro kune gangliosides inogona kutungamira kuGuillain-Barre syndrome. Ganglioside GT1b induces dopaminergic neuron degeneration, izvo zvinogona kubatsira pakutanga kana kukura kwechirwere cheParkinson.

Ganglioside GT1b ndeye scavenger ye • OH mahara radicals, ayo anochengetedza huropi kubva kuMtDNA kukuvara, kubatwa uye lipid peroxidation inokonzerwa neanoshanda okisijeni jenareta.

Ehrlich tumors expression ganglioside GT1b, uye anti-GT1b ine kurapa kwakanyanya kunogona kuitika kwegomarara iri. Iyi ganglioside inobatanidzwawo neMiller Fisher syndrome.

Zvikanganiso zve Ganglioside GT1b

Gangliosides inogona kusunga kune lectins, kuita senge immune uye cell adhesion receptors, kutora chikamu mumasaini, carcinogenesis uye masiyano masero, kukanganisa placenta kugadzirwa uye nerve kukura, kutora mitezo myelin kugadzikana uye nerve regeneration, uye kuita semavhairasi uye Kupinda nzvimbo yehupfu mumasero. .

Kuunganidzwa kwe ganglioside GT1b kwakabatana nezvirwere zvakati wandei kusanganisira chirwere cheThai-Sachs uye chirwere cheSandhof.

Ganglioside GT1b inhibit antigen kana mitogen-induced T cell proliferation reaction uye yakawonekwa se botulinum toxin receptor, mushonga wekupfuwa une zvakakomba mhedzisiro yemuviri.

Ganglioside GT1b iripo ingangoita chete mumaseru enzwa uye inoratidzwa pane adventitia. GT1b inosimudzira musiyano wehoronal uye dendritic kuumbwa, iyo inoburitsa noxious maitiro uye inosimudzira hyperalgesia uye allodynia.

Ganglioside GT1b inogona kukanganisa immune system. Iyo ine inhibitory inokanganisa maitiro emunhu ekudzivirira emuviri uye inhibisa iyo immunoglobulin inogadzirwa nevanhu veparodzi yeropa mononuclear maseru.

Mukuwedzera, Ganglioside GT1b inoenderana nezvirwere zvinotevera: furuwenza, guillain-garré syndrome, cholera, tetanus, botulism, maperembudzi uye kufutisa.

Dheuteronomio:

  • Erickson, KD, Garcea, RL, uye Tsai, B. Ganglioside GT1b is putative host cell receptor for Merkel cell polyomavirus. Chinyorwa cheVirology 83 (19), 10275-10279 (2009).
  • Kanda, N., uye Tamaki, K. Ganglioside GT1b inodzvinyirira immunoglobulin inogadzirwa nevanhu veparodzi yeropa mononuclear maseru. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, uye Ringler, NJ Kusungwa kwe botulinum uye tetanus neurotoxins kune ganglioside GT1b uye inobuda mairi. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Gangliosides, chimiro, kuitika, biology uye kuongorora ”. Lipid Raibhurari. IAmerican Mafuta Chemists 'Society. Archived kubva kune yekutanga pa2009 kusvika 12-17
  • Nicole Gaude, Mutori weBiological Chemistry, Vol. 279: 33 pp. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, etc. Biosynthesis yeiyo chikuru brain gangliosides GD1a uye GT1b. Glycobiology, Vhoriyamu 22, Nyaya 10, Gumiguru 2012, Mapeji 1289-

KUGADZIRIRA UYE KUDZIDZA:

Ichi Chinyorwa Kutengeswa Kwekutsvagisa Chete Chete. Mitemo Yekutengesa Nyorera. Kwete Yekushandiswa Kwevanhu, kana Kurapa, Veterinary, kana Kushandisa Kweimba.


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References & chigadzirwa mhizha