Ganglioside GT1b (59247-13-1)

March 15, 2020

Zita rekuti Ganglioside rakatanga kushandiswa nasayendisiti wechiGerman Ernst Klenk muna 1942 kune mapidids achangosarudzika kubva kumaseru ehuropi ...

 


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

 

Ganglioside GT1b (59247-13-1) vhidhiyo

Ganglioside GT1b Specifications

Product Name Ganglioside GT1b
Kemikari Name GANGLIOSIDE GT1B TRISODIUM MUNYU; GT1B 3NA; GT1B-GANGLIOSIDE; GT1B (NH4 + Munyu); ganglioside, gt1; (ganglioside gt1B) kubva kuhuropi hwemombe; trisialoganglioside-gt1b kubva kuhuropi hwemombe; GANGLIOSIDEGT1BTRISODIUMSALT, BOVINEBRAIN; Trisialoganglioside GT1b (NH4 + munyu)
CAS Number 59247-13-1
InChIKey SDFCIPGOAFIMPG-VLTFPFDUSA-N
Molecular Formula C95H162N5Na3O47
Molecular Weight 2158.4 g / mol
Monoisotopic Mass 2157.119189 g / mol
Melting Point N / A
SKuchengetedza temp -20 ° C
Solubility DMSO: inosungunuka
kunyoresa Mushonga; chromatography;

 

Chii Ganglioside GT1b?

Zita rekuti Ganglioside rakatanga kushandiswa nemusayendisiti wechiGerman Ernst Klenk muna 1942 kune lipids dzichangosarudzika kubva kumaseru ehuropi ehuropi. Iyo molecule rinoumbwa neglycosphingolipids (ceramides uye oligosaccharides) uye imwe kana kupfuura sialic acids yakabatana neketani yeshuga. Icho chikamu cheiyo cytoplasmic membrane iyo inodzora maseru ekushambadzira maseru zviitiko. Dzinopfuura makumi matanhatu marudzi e gangliosides anozivikanwa, uye mutsauko mukuru pakati padzo chinzvimbo uye huwandu hweNANA masara.

Ganglioside GT1b ndeimwe yemazhinji gangliosides uye trisialic ganglioside ine maviri sialic acid masara akabatanidzwa kune yemukati galactose unit. Iyo ine inhibitor mhedzisiro pane yemuviri humor immune immune. Pa0.1-10 μM, inogona kudzvinyirira kugadzirwa kwega kwega kweIgG, IgM neIgA neyevanhu peripheral eropa mononuclear maseru. Ganglioside GT1b yakave zvakare yakarongedzwa seyakagamuchira maseru receptor yeMerkel cell polyoma virus uye senzira inokwanisa kukonzera hutachiona hunokonzera Merkel cell carcinoma.

Ganglioside GT1b zvakare yakaverengerwa mune akati wandei maroni cancers uye inoonekwa seimwe ganglioside ine chekuita nehuropi metastases. Zvidzidzo zvakawana kuti GM1, GD1a, uye GT1b zvine inhibitory mhedzisiro pane epadermal kukura factor receptor kusaina uye kuomerera uye kutama kwe keratinocyte, uye kuvapo kwavo kunogona kunge kuri biomarker inobatsira yekuongorora uropi metastatic kugona.

Ganglioside GT1b inokanganisawo immune system. Ganglioside GT1b ine inhibitory mhedzisiro pane yemunhu yemunhu humor immune immune uye inhibits immunoglobulins inogadzirwa neyevanhu peripheral ropa mononuclear masero. Pane humbowo hwekuti GD1b, GT1b, uye GQ1b inogona kusimudzira kugadzirwa kweT1 cytokines nekudzivirira chiitiko cheadenylate cyclase, ichitadzisa kugadzirwa kweT2.

Se receptor iyo inocherekedza akasiyana-siyana masikisi eiyo oligosaccharide chimiro, ganglioside GT1b is receptor kuburikidza neiyo Clostridium botulinum bacterium botulinum neurotoxin inopinda nerve masero. Zvidzidzo zvakaratidza kuti tetanus toxin inopinda mutsinga dzeseroma nekudzvanya neGT1b nemamwe magenge, inokanganisa kuburitswa kwema neurotransmitters ari mukati mehusope system, uye ichikonzera kuora mitezo. Iyo botulinum yemhando C neurotoxin inopinda mutsinga yakaongorora maitiro angangoita apoptotic yemaseru anogadzirwa ganglioside GT1b inosunga pane neuroblastoma.

Uye zvakare, ganglioside GT1b inodzora zvisiri izvo kufamba kwemasero, kusanganisa, uye kuomerera kune fibronectin (FN) kuburikidza nekunangana zvakananga nemoporosiyumu ne cy5 subunit ye ​​α5β1 inclin, kutsvaga kunogona kushandiswa kuvandudza marapirwo echirwere chegomarara. Iko kusanganiswa kweGT1b uye MAG pamusoro pematonon kunogona kukonzeresa kudyidzana kweGT1b mucous membrane yemuroni, zvichikonzera kudzivirira kwekukura kwema neurite.

 

Zvakanakira Ganglioside GT1b

Ganglioside GT1b is acidic glycosphingolipid iyo inoumba lipid rafts mumukati memasero eonstatic system uye inobatanidzwa mukuwedzeredza kwemasero, mutsauko, kuomerera, chiratidzo chechiratidzo, kupindirana-kwesero-cell, tumorigenesis, uye metastasis.

Autoimmune mhinduro kune gangliosides inogona kutungamira kuGuillain-Barre syndrome. Ganglioside GT1b inokonzera dopaminergic neuron degeneration, iyo inogona kukonzera kutanga kana kukura kwechirwere chaPasinson.

Ganglioside GT1b ndeye scavenger ye • OH mahara radicals, ayo anochengetedza huropi kubva kuMtDNA kukuvara, kubatwa uye lipid peroxidation inokonzerwa neanoshanda okisijeni jenareta.

Ehrlich tumors expression ganglioside GT1b, uye anti-GT1b ine kurapa kwakanyanya kunogona kuitika kwegomarara iri. Iyi ganglioside inobatanidzwawo neMiller Fisher syndrome.

 

Zvikanganiso zve Ganglioside GT1b

Gangliosides inogona kusunga kune lectins, kuita senge immune uye cell adhesion receptors, kutora chikamu mumasaini, carcinogenesis uye masiyano masero, kukanganisa placenta kugadzirwa uye nerve kukura, kutora mitezo myelin kugadzikana uye nerve regeneration, uye kuita semavhairasi uye Kupinda nzvimbo yehupfu mumasero. .

Kuunganidzwa kwe ganglioside GT1b kwakabatana nezvirwere zvakati wandei kusanganisira chirwere cheThai-Sachs uye chirwere cheSandhof.

Ganglioside GT1b inhibits antigen kana mitogen-induction T cell kuwanda mhinduro uye yaonekwa se botulinum toxin receptor, isingawanzo toxin ine zvakakomba zvemuviri mhedzisiro.

Ganglioside GT1b inowanikwa irimo chete mumasero etsinga uye inoratidzwa pane iyo adventitia. GT1b inosimudzira kusiyanisa neuronal uye dendritic kuumbwa, iyo inoburitsa hunhu hunotyisa uye inowedzera hyperalgesia uye allodynia.

Ganglioside GT1b inogona kukanganisa immune system. Iyo ine inhibitor mhedzisiro pane yemuviri wemunhu humor immune immune uye inhibits iyo immunoglobulin inogadzirwa neyevanhu peripheral ropa mononuclear masero.

Mukuwedzera, Ganglioside GT1b ine hukama nezvirwere zvinotevera: furuwenza, guillain-garré syndrome, cholera, tetanasi, botulism, maperembudzi uye kufutisa.

 

Dheuteronomio:

  • Erickson, KD, Garcea, RL, uye Tsai, B. Ganglioside GT1b is putative host cell receptor for Merkel cell polyomavirus. Chinyorwa cheVirology 83 (19), 10275-10279 (2009).
  • Kanda, N., uye Tamaki, K. Ganglioside GT1b inodzvinyirira immunoglobulin inogadzirwa nevanhu veparodzi yeropa mononuclear maseru. Immunology 96 (4), 628-633 (1999).
  • Schengrund, C.-L., DasGupta, BR, uye Ringler, NJ Kusungwa kwe botulinum uye tetanus neurotoxins kune ganglioside GT1b uye inobuda mairi. J. Neurochem. 57 (3), 1024-1032 (1991).
  • Gangliosides, chimiro, kuitika, biology uye kuongorora ”. Lipid Raibhurari. IAmerican Oiri Chemist 'Sosaiti. Yakachengetedzwa kubva pane yekutanga 2009-12-17.
  • Nicole Gaude, Mutori weBiological Chemistry, Vol. 279: 33 pp. 34624-34630, 2004.
  • Elizabeth R Sturgill, Kazuhiro Aoki, Pablo HH Lopez, nezvimwewo Biosynthesis yemakuru gangliosides GD1a uye GT1b. Glycobiology, Vhoriyamu 22, Chinyorwa 10, Gumiguru 2012, Mapeji 1289–