Raw Tadalafil powder (171596-29-5)

October 20, 2018
SKU: 171596-29-5

Raw Tadalafil powder pasi pezita rekuti Cialis inoshandiswa kurapa kusagadzikana (kushaya simba) uye zviratidzo zvebenign prostatic ………


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum
Unyanzvi: 1190kg / mwedzi

Tadalafil poda vhidhiyo

 

Base Ruzivo

Product Name Tadalafil powder
Kemikari Name (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
muchiso Name Cialis, Adcirca
Kirasi yeMishonga PAH, PDE-5 Inhibitors; Phosphodiesterase-5 Enzyme Inhibitors
CAS Number 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
Molecular Formula C22H19N3O4
Molecular Wsere 389.4
Monoisotopic Mass 389.138 g / mol
Kunyorera Point  298-300 ° C
Freezing Point 2 ° C
Biological Half-Life 17.5 maawa
ruvara Yakachena Kuti Irege Kuvhara Cyrstalline Yakasimba
Skukodzera  Inogadziriswa muDMSO (78 mg / ml pa25 ° C), methanol, mvura (<1 mg / ml pa25 ° C), dichloromethane, uye ethanol (<1 mg / ml pa25 ° C)
Storage Temperature  Chengetedza pakushambidzika kwemukati pakati pe 59 ° F uye 86 ° F (15 ° C uye 30 ° C). Usachengete mushonga uyu munzvimbo dzine hunyoro kana nyorova.
Tadalafil APane Raw Tadalafil mapfufura, Kuita zvepabonde, Kofi yepabonde, nezvimwewo.

 

tsananguro

Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6, 3,4] pyrido [1,4-b] indole-5-dione (Cialis), rudzi rwe PDE5 inhibitor uye chinodzorerwa nemuromo. Iyo b-carboline yakatorwa uye yakarongeka zvakasiyana kubva kune vardenafil (Levitraw) uye sildenafil (Viagraw), ese ari ma PDE171596 inhibitors akavakirwa pane fused pyrimidine yakakosha mamiriro. Tadalafil powder (CAS 29-5-2003) inowedzera kuyerera kweropa kupinda mu corpus cavernosum nekuzorodza tsinga dzetsinga dzeropa, uye izvi zvinogonesa murume kuwana erection. Tadalafil powder yakagamuchirwa neUnited States (US) Kudya neDrug Administration (FDA) muXNUMX yekurapa kusagadzikana (ED), uye kutengeswa pasirese pasi pezita rekuti Cialis. Iyo inoshandiswawo kurapa pulmonary arterial hypertension uye benign prostatic hyperplasia, mamiriro umo iyo gland yeprostate inowedzerwa, zvichikonzera matambudziko nekuita weti.

Tadalafil's inosiyanisa pharmacologic ficha ndeyakareba hafu yeupenyu (maawa 17.5) uchienzaniswa neViagra neLevitra (maawa 4-5). Iyi yakareba hafu yehupenyu inoguma mukureba kwenguva yekuita uye iri, muchidimbu, inokonzeresa zita rezita reCialis re "piritsi revhiki." Iyi yakareba hafu yeupenyu zvakare ndiyo hwaro hwekuferefetwa kwazvino kwekushandiswa kwetadalafil mupermonary arterial hypertension seyakangoita-yezuva nezuva kurapa.

Mechanism of Action

Penile erection panguva yekusimudzira kwepabonde inowanikwa nekuzorora kweiyo penile artery uye corpus cavernosal zvinyoro nyoro, zvichitungamira kuwedzera kweropa kuye kuchiitiko. Iyi zororo inobvumira kuwedzera kweropa kuyerera kuburikidza neye penile artery, uku ropa iri richizadza makamuri maviri mukati penisheni inonzi Corpora cavernosa. Sezvo makamuri anozadza neropa, penis inokura yakaoma. Kugadziriswa kunopera kana tsandanyama dzikabvumirana uye neropa rakawunganidzwa rinogona kubuda nepenains.

Mhinduro iyi inopindirana nekusunungurwa kweNitric oxide (NO) kubva kumagumo emagetsi uye masero endothelial, ayo anomutsa kusangana kweCGMP mumaseru emhasuru akatsvedza uyezve inodzora kudzikisira uye kudzvinyirira kwetsinga dzeropa dzinotakura ropa kuenda nekubva kunhengo yemurume. Cyclic GMP inokonzeresa kutsetseka kwemhasuru kuzorora uye kuwedzerwa kweropa kuyerera muiyo corpus cavernosum, uye inoshatiswa neiyo cGMP yakatarwa phosphodiesterase mhando 5 (PDE5) muiyo corpus cavernosum iri padhuze nepenis. Tadalafil inhibits PDE5 uye nekudaro inowedzera nekuwedzera huwandu hwecGMP inowanikwa. Tadalafil inomisa PDE5 kubva pakuparadza cGMP uyezve inowedzera iyo inowanikwa cGMP kuti iite basa uye inokonzeresa kuti erection igare kwenguva yakareba.

Zvisinei, sezvo hafu yeupenyu hweTadalafil iri pfupi, mhedzisiro yayo inopera mukati memazuva maviri ichiita kuti PDE2 idzoke uye hutano hwako hwepabonde - huwedzere. Ungangoda kutora nguva yakareba kuti uwane zvaunoda, senge yakaderera-simba Cialis 5-4 mazuva kwemazuva 5-4.

kunyoresa

  • Erectile Dysfunction (ED)
  • Pulmonary arterial hypertension
  • Benign prostatic hyperplasia
  • Analgesic
  • Norepinephrine inotora blocker
  • Mu-opiod receptor agonist

Yakakurudzirwa Tadalafil poda Dosi

Cialis inouya yeyero, yakavharwa-firimu-uye mahwendefa akafanana nemaamondi mu5, 10 uye 20 milligram (mg) doses. Iyo yakakurudzirwa kutanga dosi yeCialis poda yekushandisa sezvainodiwa mune vazhinji varwere ndeye 10 mg, inotorwa isati yatarisirwa kuita zvepabonde.

Door yekutanga ndeye 10 mamirigiramu (mg) kanenge maminetsi e30 pamberi pebonde. Door yacho inogona kuwedzera kune 20 mg kana kuderera kusvika ku5 mg, zvichibva pane zvinobudirira uye zvinoshivirira. Asi, iyo yakakwira ndeye 20 mg seyero imwe. Iyo yepamusoro yakakurudzirwa dosing frequency kamwe kamwe pazuva mune varwere vazhinji. iyo haifanire kutora isingasviki imwechete muzana mune maawa e24. Varwere vanotarisira kuita zvepabonde kanenge kaviri pasvondo vanogona kutora dhigidhi yezuva nezuva ye5 mg, uye izvi zvinogona kuderedzwa kusvika ku2.5 mg kamwechete zuva nezuva, zvichienderana nemafungiro emunhu.

Cialis poda yekushandiswa sezvinodiwa yakaratidzwa kuvandudza basa uchienzaniswa ne placebo kusvika kumaawa e36 achitevera dosing. Naizvozvo, kana uchipa varwere pakushandiswa kwakakwana kweCialis poda, izvi zvinofanirwa kutorwa mukufungwa.

Zvakakosha kuziva kuti erection haizoitika nekungotora piritsi. Uye usatore Cialis yekusagadzikana kana iwe uri kutora Adcirca yezvirwere zvepfungwa. Beside, Tadalafil yekusagadzika ndeyekungoshandiswa chete nevakuru vane makore 18 makore uye pamusoro.

Benefits

Adala Tadalafil powder inogona kubatsira kusunungura mhasuru muprostate yako uye bladder. Izvi zvinogona kubatsira kuvandudza ako BPH zviratidzo.

Kuvandudza zviratidzo zveED, tadalafil powder inobatsira kuwedzera kuyerera kweropa kuenda kunhengo. Izvi zvinogona kukubatsira iwe kuwana uye chengeta erection. Zve tadalafil powder kuti ikubatsire kuva ne erection, iwe unofanirwa kumutswa pabonde.

♦ YePAH, tadalafil poda inoshanda kuvandudza kugona kwako kurovedza muviri nekuzorodza tsinga dzeropa mumapapu ako. Izvi zvinowedzera kuyerera kweropa.

Zvikanganiso

Pamwe pamwe nemhedzisiro yayo inodikanwa, mushonga unogona kukonzera mimwe miganho isingadiwe. Kunyangwe zvisiri zvese izvi zvinokanganisa zvingaitika, kana zvikaitika vangangoda kurapwa. Ndokumbira utarise miganho inotevera ye tadalafil powder:

Zvinowanzovhiringidza

▪ musoro

▪ kugumburwa mudumbu

▪ kurwadziwa shure

▪ musungo aches

▪ kuputika (ruvara rutsvuku)

▪ yakakosha kana yemhino yemhino

▪ manyoka

Hashoma asi zvakakomba mhedzisiro 

Kuwedzeredzwa kwenguva refu kunogona kukonzera kukuvadzwa kwepenisi, matambudziko ekuona, uye kurasikirwa kwekunzwa.

Kana izvi zvikanyoro, vanogona kuenda mukati memazuva mashoma kana masvondo mashoma. Kana vakanyanya kuoma kana kuti vasati vaenda, taurai nachiremba wako kana wemishonga.

Vanhu vane mamiriro anotevera haafanire kutora Cialis poda kunze kwekunge chiremba abvuma:

Matambudziko erumbo rwemoyo, angina, kana chero rudzi rwechirwere chemoyo

Yakakwira kana yakaderera ropa

Congestive mwoyo kukundikana kana kurohwa mukati memwedzi yekupedzisira ye6, kana myocardial infarction mukati memwedzi yekupedzisira ye3

Sickle cell anemia, akawanda myeloma, hemophilia, leukemia, kana rimwe dambudziko reropa

Chiropa kana chirwere chetsvo

Maronda emudumbu

Retinitis pigmentosa

Kuumbwa kwehurume hwepeni, senge chirwere chePyronie

Chero hutano hwehutano hwavakarairwa kuti varege kuita zvepabonde

Tadalafil kudyidzana

Paunoshandisa tadalafil, panogona kunge paine zvimwe zvinodhaka zvinogona kukanganisa mushonga, zvinogona kutungamira Kubatana kwezvinodhaka kunogona kuchinja mashandisiro ako mishonga kana kuwedzera njodzi yako yemhedzisiro yakaipa.

Tadalafil ine ine mwero synergistic mhedzisiro pane yakaderedzwa-nitrate-inoderedza muropa. Tadalafil inogona kukonzera kudonha kwakakomba muropa rako kana ikashandiswa nema nitrate, izvo zvinogona kutungamira kuzunguzika, kukomoka, uye kashoma kurohwa nemoyo kana kurohwa. Usashandise tadalafil nechero ipi inotevera: mimwe mishonga inoshandiswa kurapa chest pain / angina (nitrate senge nitroglycerin, isosorbide), zvinodhaka zvinodhaka zvinonzi "poppers" zvine amyl kana butyl nitrite.

Kana iwe uri kutorawo chirongwa cheal alpha blocker (zvakadai se doxazosin, tamsulosin) kuti uite prostate yakawedzerwa / BPH kana kukwirira kweropa, ropa rako rinogona kuderera zvikuru izvo zvinogona kutungamirira kuzinza kana kupera. Chiremba wako angatanga kurapwa nechirwere chepasi che tadalafil kana kuti shandura mishonga yako alpha blocker kuti uderedze njodzi yako yekuderera ropa.

Mune zvidzidzo zvekiriniki, kukosha kwakakura kwemhinduro kwakataurwa kusvika ku36 h ichitevera kupinza mushonga. Tadalafil inonyanya kuvezwa pamuropa neCYP3A4 kune zvimiro zvisiri kushanda zvinopesana nePDE5 uye zvinowedzerwa zvakanyanya sema metabolites mumarara uye urini. Iyo pharmacokinetics ye tadalafil haina kukanganiswa nezvinhu zvakadai sekudya uye doro, zera, kuvapo kwechirwere cheshuga, uye hunyoro kana zvine mwero hepatic kushomeka. Zviitiko zvinowanzoitika zvinokonzerwa nemishonga ndezve musoro, kurwadziwa shure, dyspepsia, uye myalgia. Pa 10 uye 20 mg doses, Tadalafil haina mhedzisiro yakakosha pakumanikidzwa kweropa uye nemoyo wemoyo uye haina kukonzera kuwanda kwezviitiko zve myocardial infarction. Mishumo isingawanzo yerections refu kupfuura 4 h uye priapism yakacherechedzwa nekushandiswa kwe tadalafil. Kufungidzira, kana ikasabatwa nemazvo, kunogona kukonzera kukuvadzwa kusati kwashandurwa nehutu. Varwere vane erection inogara yakakura kupfuura 4 h inorayirwa kutsvaga kukurumidza kurapwa. Mune varwere vane chirwere cheshuga, kugadzirisa kwebasa ne tadalafil hakuna mhaka yemhando yeshuga uye rudzi rwechirwere cheshuga.

Mamwe mishonga inogona kukanganisa kubviswa kwe tadalafil kubva mumuviri wako, izvo zvingakanganisa kuti tadalafil inoshanda sei. Mienzaniso inosanganisira azole antifungals (akadai itraconazole, ketoconazole), macrolide mishonga (yakadai clarithromycin, erythromycin), HIV runovharidzira mamwe FIs (akadai fosamprenavir, ritonavir), hepatitis C utachiona runovharidzira mamwe FIs (akadai boceprevir, telaprevir), rifampin nevamwewo .

Usatore mushonga uyu nechimwe chigadzirwa chine tadalafil kana mimwe mishonga yakafanana inoshandiswa kurapa dysfunction-ED kana pulmonary hypertension (yakadai sildenafil, vardenafil).

Nezve tadalafil kudyidzana nemamwe madhiragi kuchine zvakawanda, kana iwe uchida kushandisa mushonga ne tadalafil powder (CAS 171596-29-5), tanga kurangarira kuonana nachiremba wako uye iye achakupa zano rechokwadi uye rakavimbika.

Kuwedzera mamwe mashoko

Tadalafil powder, sildenafil powder, uye vardenafil powder zvese zvinoita nekudzivirira iyo PDE5 enzyme, asi iyi mishonga inodzivirirawo PDE enzymes 6, 1, uye 11 mumatanho akasiyana. Semuenzaniso, Sildenafil uye vardenafil inhibit PDE6, enzyme inowanikwa muziso, kupfuura tadalafil. Vamwe vashandisi veSildenafil vanoona bhuruu tinge uye vane hunhu hwakawedzera kune mwenje nekuda kwe PDE6 inhibition. Kunze kwezvo, Sildenafil uye vardenafil zvakare inhibit PDE1 kupfuura tadalafil. PDE1 inowanikwa muuropi, moyo, uye vascular midhi mushe. Izvo zvinofungidzirwa kuti kuvharirwa kwe PDE1 ne sildenafil uye vardenafil kunotungamira kune vasodilation, kufashaira, uye tachycardia.

Kuenzaniswa nekuita muPDE6 uye PDE1, tadalafil yakawedzera mukurumbira paPDE11. PDE11 inoratidzwa mumabhonzo emabhonzo, Prostate, chiropa, itsvo, chirwere chepituini, uye testes. Nekudaro, mhedzisiro pamuviri wekutadzisa PDE11 haizivikanwe.