Monosialotetrahexosylganglioside Sodium (GM1) brain brain (37758-47-7)

Dai 28, 2019
SKU: 37758-47-7

GM1 powder yakashandiswa zvikuru kurapa neonatal hypoxic-ischemic brain injury, chirwere chePalinson ...


Mamiriro: MuMitambo Yokugadzira
Synthesized and Customized Available
Unyanzvi: 1277kg / mwedzi

Monosialotetrahexosylganglioside Sodium (GM1) brain brain (37758-47-7) video

Monosialotetrahexosylganglioside Sodium (GM1) brain brain (37758-47-7) Tsanangudzo

Monosialotetrahexosylganglioside Sodium (GM1) brain brain (37758-47-7), iyo pfupi inogona kuva GM1, yakabviswa muuropi yenguruve uye iri nhengo ye ganglio series ye gangliosides ine imwe yeasialic acid.

GMl inogona kukurudzira kugadzirisa kwehutano hwemagetsi mushure mekukuvadza kwepakati yenheyo yezvirwere zvakasiyana-siyana, zvinokurudzira neuroplasticity. Ongororo dzinoratidza kukuvara kweGyl vascular brain, uropi hunotambudza kudzorera masero emagunha mumusana wechipfuva ine simba rinodzivirira uye rinokurudzira basa rechiteri.

Yakazotevera chirongwa chechipiri chechipatara chiratidzwa, chinogona kuderedza oxaliplatin-induced neurotoxicity (OIN). Asi haina kubvumirwa nechikamu chechitatu III. Chikamu chechitatu III chinotarisirwa kuti chiongorore kushanda nekuchengeteka kweMonosialotetrahexosylganglioside Sodium Injection yekudzivirira OIN pamusana wekenza.

Monosialotetrahexosylganglioside Sodium (GM1) brain brain (37758-47-7) Specifications

Product Name Monosialotetrahexosylganglioside Sodium (GM1) brain brain
Kemikari Name Monosialotetrahexosylganglioside Sodium (Porcine brain)

Kana GM1

Zvinoteverana /
muchiso Name Shenjie
Kirasi yeMishonga Sphingolipids
CAS Number 37758-47-7
InChIKey GTTLZSUWCRJZRC-CRQBLQEMSA-N
Molecular Formula C73H134N4O31
Molecular Wsere 1563.85
Monoisotopic Mass 1563.85
Kunyorera Point N / A
Biological Half-Life /
ruvara Off-white white lyophilized powder
Solubility chloroform / methanol (9: 1): 10 mg / mL, yakajeka, isina muto
chengetedzo Temperature -20 ° C
APane Zvimwe zvinogamuchirwa nekodhira chekisi inowanikwa muuropi pakupera kwevana infantile lipidosis.
Kuedza zvinhu Muimba Izvo Maitiro
Character Poda yakachena kana yakachena; kunonhuwa zvishoma, kusasviba; yakanyorova. Ichi chigadzirwa chinosvibiswa mumvura, chakanyanyiswa zvishoma mumethanol, inenge isingasviki mune ethanol anhydrous.
Chiratidzo
Mifananidzo inoshandura mhinduro 1 Tora chirongwa chekuedza 0.2ml pasi pezvakagadziriswa, wedzera mvura 2ml, uye wobva wawedzera Hydroquinone hydrochloric acid solution (hydroquinone 0.2g, wedzera mvura 10ml yakagadziriswa, uwedzere hydrochloric acid 90ml, uwedzere 0.1mol / L Copper sulfate solution 0.25ml, Firiji Preservation) 2ml, bhati yemvura inopisa ye 15 maminitsi, sarudzo yebhuruu uye yepepuru, ine Newa doro 5ml Kubviswa kwechidimbu, uye doro rakasvibiswa bhuruu.
Mifananidzo inoshandura mhinduro 2 Tora chigadzirwa ichi pamusoro 20mg, wedzera glacial acetic iine acid 1ml, inopisa kugeza mvura muchidziisa zvakazara ichiputswa, wedzera zvitatu ferric chloride bvunzo Urume 1 anosiya, muna inopisa kugeza nemvura pamwe nenyere rusvingo zvishoma nezvishoma kuwedzera sulfuric asidhi 1ml, saka kuti agadzirise huviri akaturikidzana , maviri-liquid interface inofanira kunge yakaoma
Sodium salt Izvozvo zvinoratidza kushandiswa kwe sodium inyu mune chigadzirwa (Chinese Pharmacopoeia 2015 edition yechina 0301).
Liquid chromatography (LC) Mugore chromatographic girafu akanyorwa pasi kugutsikana kutsunga, iyo chengetedzo nguva huru yepamusoro Muedzo mhinduro inofanira kupindirana nemashoko chengetedzo nguva huru yepamusoro kudzora mhinduro.
Infrared spectroscopy Mepu yekusvibiswa kwemajekiti yemuchina ino inofanira kunge yakaenderana nemepu yekudzora mishonga (Chinese Pharmacopoeia 2015 edition yechina 0402).
Ongorora
PH 5.0 ~ 6.5
Kunzwisisa uye ruvara rwechinetso Inofanira kujekeswa musingaverengeki; kana iine makore, haafaniri kuva akareba kupfuura mvura yakasvibiswa ye-turbidity No. 1th; Kana ruvara rupiro rwusingafaniri kunge rwakadzika kudarika Jaji No 1th colorimetric solution.
High Pressure determination Iyo yakagadziriswa sarudzo inofanira kuva yakajeka uye yakajeka mushure mekukwirira kwakanyanya, pasina mukaka chiedza, pasina chando
Sensitizing factor (Miscellaneous protein) ≤50000
Total Sialic acid Maererano neakaoma chigadzirwa kuverenga, saliva ine acid inofanira kuva 19.0 ~ 21.0%
Zvimwe zvine chokuita Sialic acid ≤0.3%; GD3, GD1a, tsvina isingazivikanwi i ≤ 0.5%; kusachena uye ≤2.0%
Protein ≤1.0%
High molecular weight uremeso ≤0.5%
Residual solvents Methanol ≤ 0.1%; acetone ≤ 0.3%; Trichloromethane ≤0.003%
Mvura ≤4.0%
Burning residue ≤5.0%
Simbi inorema ≤20ppm
Abnormal toxicity Kuteerera Mitemo
Antihypertensive substances Inofanira kunge yakaenderana nemitemo (yakawandisa yakawanda yehutungamiri)
Pyrogen Inofanira kunge yakaenderana nemitemo (yakawandisa yakawanda yehutungamiri)
Microbial miganhu Nhamba yose yebhakitiriya aerobic inofanira kunge iri <100cfu / g, uye nhamba yose yezvipembenene nemafuta zvinofanira kuva <50cfu / g
Kunyanya ≥98.0%

mbishi MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Tsanangudzo

Monosialotetrahexosylganglioside Sodium (37758-47-7), iyo pfupi inogona kuva GM1, yakabviswa muuropi yenguruve uye inhengo ye ganglio yakawanda ye gangliosides ine imwe yeasialic acid.

GM1 inogona kukurudzira kugadzirisa kwehutano hwemagetsi mushure mekukuvadza kwenheyo yenheyo yezvirwere zvakasiyana-siyana, kukurudzira neuroplasticity. Ongororo dzinoratidza kukuvara kweByXXUMUM vascular brain, uropi hunotambudza kudzorera masero emagunha mumusana wechipfuva ane simba rinodzivirira uye rinokurudzira basa rechiteri.

Yakazotevera chirongwa chechipiri chechipatara chiratidzwa, chinogona kuderedza oxaliplatin-induced neurotoxicity (OIN). Asi haina kubvumirwa nechikamu chechitatu III. Chikamu chechitatu III chinotarisirwa kuti chiongorore kushanda nekuchengeteka kweMonosialotetrahexosylganglioside Sodium Injection yekudzivirira OIN pamusana wekenza.

MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Meitiro yezviito?

GM1 (monosialotetrahexosylganglioside) iyo "prototype" ganglioside, inhengo ye ganglio series gangliosides ine imwe yeasialic acid. GM1 inokosha yezvinhu zvepanyama uye zvinokonzera neuronal plasticity uye nzira dzokugadzirisa, uye kusunungurwa kweeurotrophins muuropi. Kunze kwebasa rayo muhutano hwehuropi, GM1 inoita senzvimbo yekuzvisunga zvose zvekirera toxin neE E. coli kupisa-labile enterotoxin (Kurwara kwevanhu vanofamba).

Benefits of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7)

Ganglioside GM1 inhengo yemhuri ye ganglioside iyo yakashandiswa munyika dzakawanda uye inofungidzirwa senzira inopikira yokurapa kwekudzivirira zvirwere zvehutano zvakasiyana-siyana, kusanganisira cerebral ischemic kukuvara. Mishonga yekurapa yeGG1 yakaratidzwa zvose muononates uye kune vanhu vakuru vanotevera zvinokanganisa pfungwa dzepfungwa.

varumbidzwa MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Dosage

Zvinodhaka zvakashandiswa pamushandi we 20-40 mg zuva nezuva nekujaira kwemukati kana kuti zvishoma nezvishoma mumakumbo maererano nemazano echiremba. Muchikamu chakaoma chekuchinja kwehutachiona: Mishonga yakashandiswa pachirwere che 100 mg zuva nezuva nejeri remukati; Mushure memasvondo e2-3, kazhinji vanochengetedza huwandu hwe20-40 mg zuva rimwe nerimwe kwemavhiki matanhatu, muzana wekutanga we500-1000 mg waitungamirirwa nekugumburwa kwepachivande chePalinson's disease; kubvira pazuva rechipiri, zvinodhaka zvakashandiswa pamwe neyero re 200 mg zuva nezuva nejasi remukatikati, chirwere chepramuscular kana kuvharirwa kwemavhiki kwe18 kazhinji. apo ichi chirwere chaitungamirirwa neAppcutaneous kana intravenous injection, inofanira kuputswa uye yakanatswa mumvura kuti iwanike mujeri kusvikira kuiswa kwe 10 mg / ml pa; kana kuvhara kweputika, mishonga yakanga isingadiwi uye yakanatswa mu 0.9% sodium chloride injection kana 5% glucose injection.

Zvikanganiso of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7)

Nhengo yechipfuva cheGG1 poda inonyanya kushandiswa kugadzirisa mushure mekushandisa.