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Anandamide (AEA) (94421-68-8)

Anandamide, inozivikanwawo seN-arachidonoylethanolamine (AEA), ndeye fatty acid neurotransmitter inotorwa kubva ku …… ..


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Anandamide (AEA) (94421-68-8) Specifications

Product Name Anandamide (AEA)
Kemikari Name Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

N-Arachidonoyl-2-hydroxyethylamide; Arachidonoyl ethanolamide; AEA;

CAS Number 94421-68-8
InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
kunyemwerera CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
Molecular Formula C22H37NO2
Molecular Weight 347.53
Monoisotopic Mass 347.282429 g / mol
Melting Point N / A
Boiling Point 522.3 ± 50.0 ° C (Zvakafanotaurwa)
Density 0.92 g / mL pa25 ° C (lit.)
ruvara light yellow
Storage temp -20 ° C
Solubility ethanol: soluble
kunyoresa Izvo zvinoshandiswa kuyeuka, kukurudzira, kuchenjera maitiro, kufamba kwekutonga, kurwadza kwemaronda, kusimbisa kudya uye kubereka.

Chii chinonzi Anandamide (AEA)?

Anandamide, inozivikanwawo seN-arachidonoylethanolamine (AEA), ndeye fatty acid neurotransmitter inotorwa kubva kune isiri-oxidative metabolism ye eicosatetraenoic acid (arachidonic acid. Iyo ine chimiro chakafanana chaizvo neiyo tetrahydrocannabinol, iyo inoshanda inzvimbo ye cannabis. yakasvibiswa zvakanyanya neiyo fatty acid amide hydrolase (FAAH) enzyme, iyo inoshandura anandamide mu ethanolamine uye arachidonic acid, Pakupedzisira, Anandamide yakagadzirirwa muuroni neyemagetsi maitiro anoitika pakati pearachidonic acid uye ethanolamine pasi pekutungamirirwa kwecalcium ion uye cyclic monophosphate adenosidase. Icho chinotungamira cheboka rezvinhu zvemuviri zvinoshanda (Prostamides) zvinotora chikamu chezviitiko zvakawanda zvemuviri, zvinosanganisira chishuwo, kurangarira, kurwadziwa, kushushikana, uye kubereka .. Mukuwedzera, Anandamide zvakare inhibit vanhu vanhu Kuwedzera kwemasero ekenza yemazamu.

Anandamide iripo mune zvakawanda zvipenyu, zvakadai segungwa urchin roe, nguruve 'uropi uye mbeva livers, nezvimwewo, asi huwandu hwayo idiki. Zvakare, vaongorori vakawanawo Anandamide uye zvinhu zviviri (N-oleoylethanolamine uye N-Linoleylethanolamine) mune yakasviba chokoreti. Anandamide kunyange iripo mune mamwe maProteed zviyo, (chena chingwa), Doro (zvakanyanyisa, kushandiswa kusingaperi kana kunwa kunwisa), shuga yakatsanangurwa, Mafuta ekufambisa, Zvikafu zvakarongedzwa mumafuta emiriwo uye zvisiri-zvisikwa zvechikafu zvine mishonga yekuuraya zvipuka.

Sechikamu cheiyo endocannabinoid system (ECS), Anandamide inorongedzwa semutongi we homeostasis pamwe chete neimwe kirasi ye cannabis-kufanana kemikari 2-AG uye endo native cannabinoid receptors mumuviri wese. Iyi system iripo Mune ese mavertebrates. Anandamide anoita basa rekugadzirisa maitiro ekudyisa uye neurogenic kukurudzira uye kufara, kuchengetedza muviri wedu nepfungwa zviri pakati. Zvidzidzo zvakawana kuti manzwiro edu, mufaro, kutya, kusagadzikana, uye kugona kumira kwekushushikana zvese zvinogadziriswa ne endocannabinoid system, uye dzakasiyana siyana zvirwere kubva kune schizophrenia kusvika mukushungurudzika inoperekedzwa neisingawanzo anoramide mazinga.

Anandamide, yakafanana neTHC, ndeye chidimbu agonist yeCB1R. Izvo zvinogona kukonzera zvinogona kuvandudzwa ne "kuzara" activation yehuropi system. Izvo zvakakosha kucherechedza kuti zvese izvi zvinokanganisa Anandamide zvinoita sekunge zvinowedzerwa neechemacologic inhibiting its metabolic kudzikiswa. Kuwanikwa kwa Anandamide kunogona kukonzera kukudziridzwa kwemhuri nyowani yemishonga yekurapa.

Anandamide (AEA) inobatsirwa

Anandamide, inozivikanwawo se "bliss molecule", inosimudzira inosimudzira, neurotransmitter uye endocannabinoid, ine hutano hwakawanda uye hutano hwepfungwa.

Anandamide inoderedza kuumbwa nekukurumidza kwemasero ekenza. Muna 1998, boka revasayendisiti vemuItaly vakawana kuti anandamide inogona kukurudzira neurogeneis uye vogadzira mitsva yenzara, nekukasira kuumbwa / kuwedzera kukosha kwemasero emukenza yemazamu.

Kugona kwa Anandamide kusimudzira neurogeneisis (kuumbwa kwenyonganiso mutsva) kunoita basa rekudzora maitiro ekudyisa uye kuburitsa kukurudzira uye kunakidzwa mumakonzo. Izvi zvinobatsira kudzikisa zviratidzo zvekushungurudzika uye kusagadzikana. Chidzidzo chakaitwa muna 2015 chevanhu nemakonzo chakawana kuti yakakwirira yeazvamide inogona kukurudzira kugadzirisa kwemamiriro uye kuderedza kwekutya.

Uyezve, kugona kwaWamamide kusungira kuCB1 neBB2 receptors kuchakanganisawo zvakanyanya mashandiro emuviri, kuratidza zvakanaka zvakanaka maererano nekurangarira, kukurudzira, maitiro euchenjeri, kutenderera kwekutenderera, kudzora kurwadziwa, kushungurudzika kukurudzira uye kubereka.

Maitiro ekuwedzera anandamide(AEA) nhanho mumuviri wemunhu?

Nekuti anandamide ine basa seyakaitwa neurotransmitter, vasodilator mumiriri uye yeropa revanhu serum metabolite, uye hutano uye kubatsira kwepfungwa kwakaratidzwa, ungangoda kuwedzera mwero we anandamide mumuviri wako. Hedzino dzimwe nzira dzekuwedzera kwenguva pfupi maamamamide mumuviri wemunhu:

- Exercisra

Chidzidzo ichi chakaona kuti mushure memaminitsi makumi matatu chete ekumhanya, anondamide (AEA) zviri mukati mevanhu neimbwa zvakawedzera. Saka kana iwe uchida kubatsirwa zvakanyanya, ita kumwe kurovedza muviri kazhinji.

- Kudya chokoreti yakasviba

Chokoreti yakasviba ine chikamu chepamusoro cheiyoobromine mune chokoreti ine hutano, uye theobromine inobatsira kuwedzera achiwanide kugadzirwa muuropi uye kwenguva pfupi inoderedza kupwanya kwayo.

- Kudya dema truffle

Nhema truffle (dema fungus) zvakasikwa ine anandamide. Kunyangwe fungus isingakwanise chaizvo kushandisa anandamide munzira ipi neipi, vatsvagiri vanofunga kuti inoshandiswa kukwezva mhuka kuti idye uye kubereka kwayo spores.

- Kuwana tarisiro

Tsvagurudzo inoratidza kuti kana munhu ari mune imwe nzvimbo (inonzi "inoyerera" kana "mudunhu,") yekushushikana zvakanyanya, kuita, uye kuiswa, kwete chete iwe unozova unobereka zvakanyanya kana kugadzira mabasa ari nani muuropi hwako Zvinoburitsawo a nhamba huru yemakemikari, akadai serotonin, dopamine, endorphin uye anandamide.

Uyezve, tii, coriander uye celery inogonawo kubatsira kuwedzera kugadzirwa kwe anandamide.

Dheuteronomio:

  • Berger, Alvin; Crozier, Gayle; Bisogno, Tiziana; Cavaliere, Paolo; Innis, Sheila; Di Marzo, Vincenzo (15 Chivabvu 2001). "Anandamide uye chekudya: Kusanganiswa kwezvekudya arachidonate uye docosahexaenoate kunotungamira kuwedzera huwandu hwehuropi hweiyo N-acylethanolamines inoenderana muhara". Kuitika kweNational Academy yeScience. 98 (11): 6402- Bibcode: 2001PNAS… 98.6402B. doi: 10.1073 / pnas.101119098. PMC 33480. PMID 11353819.
  • El-Talatini MR, Taylor AH, Konje JC (Kubvumbi 2010). "Hukama pakati pemazinga eplasma e-endocannabinoid, anandamide, zvepabonde steroid, uye gonadotrophins panguva yekuenda kumwedzi". Fertil. Steril. 93 (6): 1989– Doi: 10.1016 / j.fertnstert.2008.12.033. PMID 19200965.
  • Habib, Abdella M .; Okorokov, Andrei L .; Chikomo, Matthew N .; Bras, Jose T .; Lee, Man-Cheung; Li, Shengnan; Gossage, Samuel J .; van Drimmelen, Marie; Morena, Maria (Kurume 2019). "Microdeletion mune pseudogene inoonekwa mumurwere ane yakakwirira anandamide yakagadzikana uye kurwadziwa kusaziva". Britain Chinyorwa cheAnesthesia. 123: e249- doi: 10.1016 / j.bja.2019.02.019. PMID 30929760.
  • Mahler SV, Smith KS, Berridge KC (Mbudzi 2007). "Endocannabinoid hedonic hotspot yemafaro epfungwa: anandamide mutiyusplus bokeni inosimudzira 'kufadza' kwemubairo unotapira”. Neuropsychopharmacology. 32 (11): 2267– doi: 10.1038 / sj.npp.1301376. PMID 17406653.
  • Mechoulam R, Fride E (1995). "Iyo nzira isina kugadziriswa inoenda kune endo native brain cannabinoid ligands, anoramides". MuPertwee RG (ed.). Iyo canannabinoid receptors. Boston: Yedzidzo Press. mapeji.
  • Mallet PE, Beninger RJ (1996). "Iyo endo native cannabinoid receptor agonist anandamide inokanganisa ndangariro mumakonzo". Behavioral Pharmacology. 7 (3): 276- Doi: 10.1097 / 00008877-199605000-00008.

KUGADZIRIRA UYE KUDZIDZA:

Ichi Chinyorwa Kutengeswa Kwekutsvagisa Chete Chete. Mitemo Yekutengesa Nyorera. Kwete Yekushandiswa Kwevanhu, kana Kurapa, Veterinary, kana Kushandisa Kweimba.


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