Raw Lorcaserin HCL powder (846589-98-8)

October 30, 2018

Raw Lorcaserin hydrochloride powder is serotonin 2C (5-HT2C) receptor agonist uye nemuromo inotungamirwa mishonga inosimudzira….


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum
Unyanzvi: 1380kg / mwedzi

Raw Lorcaserin HCL powder (846589-98-8) video

 

Raw Lorcaserin HCL powder (846589-98-8) Tsanangudzo

Product Name Raw Lorcaserin Hydrochloride powder
Kemikari Name Raw Lorcaserin HCL powder, Lorcaserin
muchiso Name BELVIQ
Kirasi yeMishonga 5-HT2C receptor inhibitor
CAS Number 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
Molecular Formula C11H15Cl2N
Molecular Wsere 232.15
Monoisotopic Mass 231.058154899
Kunyorera Point  Kwete dheinhare iripo
Freezing Point Kwete dheinhare iripo
Biological Half-Life Iyo hafu yeupenyu ye lorcaserin inenge maawa anenge 11.Porcaserin poda inobviswa zvikuru mumuginha (92%) uye mumhuka (2.2%)
ruvara White powder
Solubility  Mvura Inogadziriswa: 0.0709 mg / mL
chengetedzo Temperature  -20 ° C.
APane Serotonin 2C (HT2C) rector agonist yekurema kwekurema. Kunodha kudya kwekudya nekusimudzira satiety mukati

 

Raw Lorcaserin Hcl powder (846589-98-8) Tsanangudzo

Raw Lorcaserin hydrochloride powder ndeye hydrochloride yakawanikwa nekuita kwe lorcaserin powder neyakaenzana nehydrochloric acid. Inoshandiswa semushonga unorwisa kufutisa. Lorcaserin hydrochloride ndeye 5HT2c receptor agonist inoratidzwa kuti ishandiswe muvakuru vane BMI -30, kana avo vane BMI -27 uye angangoita mamiriro ane huremu hwakadai sehypertension, rudzi rwechipiri chirwere cheshuga kana dyslipidemia. inokonzeresa kunzwa kwekuguta, uye inofungidzirwa kudzivirira kunaya kwechirwere chemoyo chevharvosi chinosanganisirwa nekumisikidza kwe2-HT5B receptors, iyo nzvimbo yehuropi inozivikanwa kuita basa rakakura mukugadzirisa nzara uye kudya kwekudya. Nekuita izvi zvinogamuchirwa, Lorcaserin hydrochloride poda inogona kudzora kushandiswa kwechikafu nekudzora chishuwo uye kuita kuti munhu anzwe kuguta kunyangwe mushure mekudya chikafu chidiki pane zvakajairwa. yakabvumidzwa nhasi neDFA mune yakasarudzika sarudzo mushure memakore maviri ekuongororwa.

Lorcaserin hydrochloride powder inonyatsoratidzirwa sechinhu chinogadziriswa kuderedzwa-kudya koriori uye kuwedzerwa kwemuviri wekuita kwehuwandu hwehutano hwehutano muhutano hwevanhu vakuru (BMI ye30 kg / m2 kana kuti mukuru) uye vanhu vanorema kudarika (BMI ye27 kg / m2 kana kupfuura) ine nhengo imwechete inorema-yakasangana nayo.

Lorcaserin hydrochloride powder inoshandiswa pamwe chete nezvokudya uye maitiro ekurapa kuneta. Iyo dzimwe nguva inoshandiswa kurapa kuneta kunogona kuwirirana nechirwere cheshuga, cholesterol yakakwirira, kana kuwedzerwa kweropa.

Lorcaserin hydrochloride haigoni kubata chero hupi hwehutano hwehutano (hwakadai sehutano hwepfungwa, chirwere cheshuga, kuwedzerwa kweropa). Ramba uchitora chero mimwe mishonga yako chiremba akaraira kuti uite izvi.

Lorcaserin Hcl powder (846589-98-8) Mechanism of Action

Kunyange zvazvo chaiyo nzira isingazikanwi, inofungidzirwa kuti inosanganisira kusarudza kushandiswa kwe-5-HT2C receptors mune anorexigen pro-opiomelanocortin neurons mumusana we arcuate we hypothalamus. Izvi zvinokonzera kuderera kwekudya kudya uye kuve nekugadzikana nekusimudzira kusunungurwa kwe alpha-melanocortin inokurudzira hormone, iyo inoshanda pa melanocortin-4 receptors.

Lorcaserin hydrochloride powder inoshanda nekudzora chishuwo - kunyanya nekumisikidza brain receptors kune serotonin, iyo neurotransmitter iyo inokonzeresa manzwiro ekugutsikana uye kugutsikana Kudya kwechikafu kunodzorwa ne satiety Center, iri mu ventromedial nucleus ye hypothalamus uye nzara nzvimbo iripo mune lateral hypothalamus. Zvinhu zvakasiyana siyana zvinobva kunzvimbo dzakakwirira uye maturakiti emudumbu zvinosangana mune arcuate nucleus, uko marudzi maviri emauroni anotonga kudya kunowanikwa. Kutanga, chikafu chinodya chinokurudzira chinogadzira mapuroteni ane hukama neagouti uye neuropeptide Y; uye chechipiri, chikafu chinodya inhibitory boka rine cocaine uye amphetamine inodzorwa zvinyorwa (CART) uye pro-opiomelanocortin (POMC) neurons. POMC ine 5-HT 2C receptors, iyo painomisikidzwa ikaburitsa alpha-melanocyte-inosimudzira mahormone (alfa-MSH) .Zvese zviri zviviri zvinodzivirira uye zvinokurudzira mauroni zvinowedzera mapurojekiti epasirosi mu hypothalamus. Paraventricular nucleus ine melanocyte 4 receptors (MC4R) iyo inotitadzisa kudya mune yekurapa doses lorcaserin hydrochloride powder inoita senge inosarudza 5-HT 2C agonist paPOMC neurons, inova iyo inokonzeresa kuburitsa alfa MSH. Kuenderera mberi alfa MSH inoshanda paMC4R mune paraventricular nucleus muiyo hypothalamus, zvichikonzera kudzikira mukuda. Mune supratherapeutic doses, lorcaserin hydrochlorider inoshandawo pa5-HT 2B uye 5-HT 2A receptors.

Benefits yeLorcaserin Hcl powder (846589-98-8)

  • Lorcaserin HCL powder inosarudza 5-HT2C receptor agonist iyo inofungidzirwa kuderedza kudya kwekudya kuburikidza nepakati pePOMC system. Lorcaserin HCL powder zvakabatsirwa:
  • Lorcaserin HCL powder inoshandiswa pamwe chete nezvokudya uye maitiro ekurovedza kuneta.
  • Lorcaserin HCL powder dzimwe nguva inoshandiswa kurapa kuneta kunogona kuwirirana nechirwere cheshuga, cholesterol yakakwirira, kana kuwedzerwa kweropa.
  • Lorcaserin HCL powder haigoni kubata chero hupi hwehutano hwehutano (hwakadai sehutano hwepfungwa, chirwere cheshuga, kuwedzerwa kweropa).

Yakakurudzirwa Lorcaserin Hcl powder (846589-98-8) Dosage

Lorcaserin HCL powder inouya mufomu yepiritsi uye inotorwa kazhinji 1-2 nguva pazuva, kana kana pasina chikafu. Lorcaserin inofanira kushandiswa pamwe chete neyakaderera koriori chikafu uye chirongwa chekurovedza muviri.

Iyo yakakurudzirwa dosi ye lorcaserin hcl powder ndeye 10 mg inotungamirwa nemuromo kaviri pazuva. Lorcaserin inogona kutorwa pasina hanya nezvekudya. Lorcaserin hcl inofanirwa kumiswa muvarwere vanokundikana kuwana kana 5% yekudzikira uremu nevhiki yegumi nembiri sezvo varwere ava vasingakwanise kuwana kurasikirwa kwehuremu zvine musoro nekuenderera mberi nekurapwa.

Zvikanganiso yeLorcaserin Hcl powder (846589-98-8)

Lorcaserin Hcl poda inoshandiswa pakurapa kwekusingaperi uremu manejimendi mune vakuru vane muviri mashoma index (BMI) ye30 kana mukuru (akafutisa) sekuwedzera kune yakaderedzwa-koriori chikafu uye kurovedza muviri. Inotenderwawo kuti ishandiswe nevanhu vakuru vane BMI yemakumi maviri nemanomwe kana kupfuura (kuwandisa) uye vane hunhu hunenge hune hukama-hwakadai sekukwira kweropa (hypertension), kana cholesterol (dyslipidemia). Nekudaro, zvakare inogona kuve neimwe mhedzisiro. Sezvo pazasi:

 Tiye anowanzovhiringidza madhara:

  • -Headache,
  • -Dzinziness,
  • -Fatigue,
  • -Nausea,
  • -Shamba muromo,
  • -Contipation, uye
  • -Hyglycemia (shuga shoma yeropa).

 Zvimwe zvinowanzoitika asi zvinokonzera mimwe migumisiro yakaoma inosanganisira lorcaserin inosanganisira:

  • -Ava nematambudziko emagetsi,
  • -Changisisa mukucherechedza kana kuyeuka,
  • -Matambudziko epfungwa,
  • -Dambudziko kana pfungwa dzekuzviuraya,
  • -Zvirevo zvakanyanya,
  • -Kuderera kwemoyo,
  • -Donho muropa cell count, uye
  • -Ikuwedzera mune hormone, prolactin.