Nicotinamide adenine dinucleotide (53-84-9)

March 15, 2020

Nicotinamide adenine dinucleotide (NAD) inogadzirisa inobatsira metabolism inowanikwa mumasero ese mupenyu. Iripo nenzira mbiri …….

 


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

 

Nicotinamide adenine dinucleotide (53-84-9) vhidhiyo

Nicotinamide adenine dinucleotide (53-84-9) S.pecifications

Product Name Nicotinamide adenine dinucleotide (NAD +)
Kemikari Name Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide Enzopride;
CAS Number 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
kunyemwerera C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Molecular Formula C21H27N7O14P2
Molecular Weight 663.4 g / mol
Monoisotopic Mass 663.109123 g / mol
Melting Point 160 ° C (320 ° F; 433 K)
ruvara Chena
SKuchengetedza temp 2-8 ° C
Solubility H2O: 50 mg / mL
kunyoresa Zvehutano zvekudya, zvekushambidzika, zvekudya zvinowedzera

 

Chii Nicotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) ndeye cofactor inobatsira metabolism inowanikwa mumasero ese mupenyu. Iyo irimo mumhando mbiri, oxidized (NAD +) uye yakaderedzwa (NADH).

Coenzyme NAD +, iyo oxidised fomu yeNAD, yakatanga kuwanikwa muna 1906 neBritish biochemists Arthur Harden naWilliam John Young. NAD + yakagadzirirwa maviri metabolic pathways, ayo anogona kugadzirwa kubva ku de novo amino acid nzira, kana anogona kugadzirwa nekudzokorodza pre-maumbirwo anoumbwa (akadai nicotinamide) odzoka kunzira yekununura yeNAD +. Iyo yakakosha pyridine nucleotide uye inoshanda seyakakosha cofactor uye substrate yemazhinji akakosha masero maitiro anosanganisira oxidative phosphorylation uye ATP kugadzirwa, kugadziriswa kweDNA, epigenetic kudzora kwema gene expression, intracellular calcium signaling uye Immunological basa.

NAD + ndiyo huru yemagetsi anogamuchira mamorekuru mune yebiology oxidation. Iyo inogamuchira maelekitori kubva kune mamwe mamorekuru uye yakadzikira. Inoita zvakare se coenzyme ye hydride transferase uye substrate inodya NAD (+) polymerase, uye inogadzira coenzyme redox joini yakaderedzwa β-nicotinamide adenine dinucleotide (NADH). NAD (R) ndiyo iyo ADP-ribose donor unit ribosylation muADP-A. Iyo zvakare iri pamberi pe cyclic ADP-ribose (ADP-ribosyl cyclase).

Se oxidant mune cell metabolism, NAD (R) inoitawo basa muadenosine diphosphate (ADP) -kupa kutapurirana kwekuchinja kunosanganisira diadenylate (ADP-ribose) polymerase uye akati wandei mamwe enzymatic maitiro. Inogona kudzivirira NAD kudzivirira kana kudzikisa chirwere cheshuga, kenza uye zvimwe zvirwere zvine chekuita nezera. Zvakare, NAD + zvinowedzera zvinogona kushanda zvakabatana nemishonga inowedzera senge resveratrol kubatsira kumutsidzira mitochondria uye kurwisa zvirwere zvekukwegura.

 

Nicotinamide adenine dinucleotide(NAD +) zvinobatsira

Seiyo inoshanda oxidant, Nicotinamide adenine dinucleotide inoratidza kuti zvimwe zvakanaka zvinobatsira mumabasa evanhu.

Im Gonesa chiitiko chako chema cell,

♦ Wedzera simba rako zvakasununguka;

♦ Kuvandudza kushanda kwehuropi, kutarisa uye ndangariro;

Ost Wedzera metabolism yako;

♦ Kuvandudza kurara;

♦ Ita basa repasirese sirtuin;

♦ Kuvandudza kushanda nesimba kwe antioxidant;

♦ Deredza kuzvimba;

♦ Yakagadziridzwa chiyero, mafungiro, maonero uye kunzwa;

Nicotinamide adenine dinucleotid zvakare yakanangana nechinodhaka isoniazid, iyo inoshandiswa pakurapa tuberculosis, hutachiona hunokonzerwa neMycobacterium tibhii. Mune kumwe kuyedza, mbeva dzakapihwa NAD kwevhiki imwechete dzaive dzakavandudza nyukireya-mitochrondrial kutaurirana.

Uye zvakare, Nicotinamide adenine dinucleotide (NAD +) zvakare ine kudzivirira uye kurapwa kwemwoyo block, sinus node function uye inopokana nekukurumidza yekuedza arrhythmias, nicotinamide inogona zvakanyanya kuvandudza chiyero chemoyo uye atriove ntricular block inokonzerwa ne verapamil.

 

Nicotinamide adenine dinucleotide(NAD +) Application:

  1. Diagnostic reagents zvigadzirwa, zvesayenzi yekutsvaga kwekuedza.
  2. Zvehutano zvekudya, zvekushambidzika, zvekudya zvinowedzera
  3. API kugadzirwa

 

More Nicotinamide adenine dinucleotide(NAD +) tsvagurudzo

Ma enzymes anogadzira uye anoshandisa NAD + neNADH akakosha mune zvese pharmacology uye nekutsvaga mune ramangwana kurapwa kwezvirwere. Iyo coenzyme NAD + haisi iyo pachayo inoshandiswa senzira yekurapa chero chirwere. Nekudaro, iri kuongororwa kuti inogona kushandiswa pakurapa kwezvirwere zveeurodegenerative sengeAlzheimer's uyeParkinson chirwere.

 

Dheuteronomio:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism muhutano uye chirwere" (PDF). Maitiro Biochem. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Yakachengetedzwa kubva kune yekutanga (PDF) musi wa4 Chikunguru 2009. Yakadzorerwa 23 Zvita 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Kuzivikanwa kwemitochondrial NAD + mutakuri muSaccharomyces cerevisiae". J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (Kubvumbi 2003). "Nicotinamide adenine dinucleotide, inogadzirisa metabolic yekunyora, kurarama kwenguva refu uye chirwere". Curr. Opin. Cell Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Iyo redox mamiriro emahara nicotinamide-adenine dinucleotide mu cytoplasm uye mitochondria yegonzo chiropa". Biochem. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Kurume 1980). "Nicotinamide adenine dinucleotide biosynthesis uye pyridine nucleotide cycle metabolism mune microbial system". Microbiol. Zvak. 44 (1): 83– PMC 373235. PMID 6997723.
  • French SW. Kubata doro risingaperi kunokuvadza chiropa uye dzimwe nhengo nekuderedza nhanho dzeNAD⁺ dzinodiwa kuitira sirtuin's deacetylase chiitiko. Exp Mol Mol. 2016 Kubvumbi; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins uye NAD + muKubudirira uye Kurapa kweMetabolic uye Cardiovascular Disease. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.