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Nicotinamide adenine dinucleotide (53-84-9)

Nicotinamide adenine dinucleotide (NAD) ndeye cofactor inobatsira metabolism inowanikwa mumasero ese mupenyu. Ririmo mune maviri mafomu …….


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

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Nicotinamide adenine dinucleotide (53-84-9) Specifications

Product Name Nicotinamide adenine dinucleotide (NAD +)
Kemikari Name Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide Enzopride;
CAS Number 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
kunyemwerera C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Molecular Formula C21H27N7O14P2
Molecular Weight 663.4 g / mol
Monoisotopic Mass 663.109123 g / mol
Melting Point 160 ° C (320 ° F; 433 K)
ruvara Chena
Storage temp 2-8 ° C
Solubility H2O: 50 mg / mL
kunyoresa Zvehutano zvekudya, zvekushambidzika, zvekudya zvinowedzera

Chii Nicotinamide adenine dinucleotide(NAD +)?

Nicotinamide adenine dinucleotide (NAD) ndeye cofactor inobatsira metabolism inowanikwa mumasero ese mupenyu. Iyo irimo mumhando mbiri, oxidized (NAD +) uye yakaderedzwa (NADH).

Coenzyme NAD +, iyo oxidised fomu yeNAD, yakatanga kuwanikwa muna 1906 neBritish biochemists Arthur Harden naWilliam John Young. NAD + yakagadzirirwa maviri metabolic pathways, ayo anogona kugadzirwa kubva ku de novo amino acid nzira, kana anogona kugadzirwa nekudzokorodza pre-maumbirwo anoumbwa (akadai nicotinamide) odzoka kunzira yekununura yeNAD +. Iyo yakakosha pyridine nucleotide uye inoshanda seyakakosha cofactor uye substrate yemazhinji akakosha masero maitiro anosanganisira oxidative phosphorylation uye ATP kugadzirwa, kugadziriswa kweDNA, epigenetic kudzora kwema gene expression, intracellular calcium signaling uye Immunological basa.

NAD + ndiyo huru yemagetsi anogamuchira mamorekuru mune yebiology oxidation. Iyo inogamuchira maelekitori kubva kune mamwe mamorekuru uye yakadzikira. Inoita zvakare se coenzyme ye hydride transferase uye substrate inodya NAD (+) polymerase, uye inogadzira coenzyme redox joini yakaderedzwa β-nicotinamide adenine dinucleotide (NADH). NAD (R) ndiyo iyo ADP-ribose donor unit ribosylation muADP-A. Iyo zvakare iri pamberi pe cyclic ADP-ribose (ADP-ribosyl cyclase).

Semunhu oxidant mu cell metabolism, NAD (R) inoitawo basa adenosine diphosphate (ADP) -kupa maitiro ekuchinja anosanganisira diadenylate (ADP-ribose) polymerase uye akati wandei mamwe enzymatic maitiro. Iyo inogona preventively kupa NAD kudzivirira kana kuderedza chirwere cheshuga, cancer uye zvimwe zvirwere zvine hukama. Zvakare, NAD + boosters inogona kushanda synergistically pamwe nezvinowedzera senge resveratrol kubatsira kubatsira rejuvenate mitochondria uye kurwisa zvirwere zvekusakara.

Nicotinamide adenine dinucleotide(NAD +) zvinobatsira

Seiyo inoshanda oxidant, Nicotinamide adenine dinucleotide inoratidza kuti zvimwe zvakanaka zvinobatsira mumabasa evanhu.

♦ Ongorora basa rako rema cellular,

♦ Wedzera simba rako zvisikwa;

♦ Kuvandudza uropi kushanda, kutarisa uye ndangariro;

♦ Wedzera yako metabolism;

♦ Kuvandudza kurara;

♦ Kukurudzira epasi rose Sirtuin chiitiko;

♦ Kuvandudza antioxidant kubudirira;

♦ Kuderedza kuzvimba;

♦ Yakavandudzika chiyero, mhirizhonga, kuona uye kunzwa;

Nicotinamide adenine dinucleotid zvakare yakatarisana yakananga yeiyo mushonga isoniazid, iyo inoshandiswa mukurapa kwezvetuberculosis, hutachiona hunokonzerwa neMycobacterium tuberculosis. Mune kumwe kuyedza, makonzo akapihwa NAD kwevhiki imwe chete yakavandudza kutaurirana kwenyukireya-mitochrondrial.

Uye zvakare, Nicotinamide adenine dinucleotide (NAD +) zvakare ine kudzivirira uye kurapwa kwemwoyo block, sinus node function uye inopokana nekukurumidza yekuedza arrhythmias, nicotinamide inogona zvakanyanya kuvandudza chiyero chemoyo uye atriove ntricular block inokonzerwa ne verapamil.

Nicotinamide adenine dinucleotide(NAD +) Application:

  1. Diagnostic reagents zvigadzirwa, zvesayenzi yekutsvaga kwekuedza.
  2. Zvehutano zvekudya, zvekushambidzika, zvekudya zvinowedzera
  3. API kugadzirwa

More Nicotinamide adenine dinucleotide(NAD +) tsvagurudzo

Ma enzymes anogadzira uye anoshandisa NAD + uye NADH akakosha mune zvese zviri zviviri pharmacology uye kutsvaga mune kurapwa kwemangwana kwechirwere. Iyo coenzyme NAD + haisi iyo pachayo inoshandiswa sekurapa kwechirwere chero chipi. Nekudaro, iri kudzidziswa nekuda kwekushandisa kwayo kurapa kwechirwere chechirwere chechirwere chechirwere chechirwere chakadai seAlzheimer's andParkinson chirwere.

Dheuteronomio:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism muhutano uye chirwere" (PDF). Maitiro Biochem. Sci. 32 (1): 12– Doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Akachengetedzwa kubva kune yekutanga (PDF) musi 4 Chikunguru 2009. Retrieved 23 December 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Kuzivikanwa kweiyo mitochondrial NAD + transporter mu Saccharomyces cerevisiae". J. Biol. Chem. (281) PMID 3.
  • Lin SJ, Guarente L (Kubvumbi 2003). "Nicotinamide adenine dinucleotide, metabolic inobata yekunyora, hupenyu hurefu uye chirwere". Curr. Opin. Cell Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "Iyo redox mamiriro emahara nicotinamide-adenine dinucleotide mune cytoplasm uye mitochondria yeti rat chiropa". Biochem. J. 103 (2): 514- doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Kurume 1980). "Nicotinamide adenine dinucleotide biosynthesis uye pyridine nucleotide kutenderera metabolism muhutachiona masisitimu". Microbiol. Zvak. 44 (1): 83– PMC 373235. PMID 6997723.
  • French SW. Kurwara doro kusingagumi kunokuvadza chiropa uye dzimwe nhengo nekudzikisa nhanho yeNAD⁺ inodikanwa yechiitiko cheSirtuin. Exp Mol Pathol. 2016 Apr; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. Sirtuins uye NAD + muKubudirira uye Kurapa kweMetabolic uye Cardiovascular Disease. Circ Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.

KUGADZIRIRA UYE KUDZIDZA:

Ichi Chinyorwa Kutengeswa Kwekutsvagisa Chete Chete. Mitemo Yekutengesa Nyorera. Kwete Yekushandiswa Kwevanhu, kana Kurapa, Veterinary, kana Kushandisa Kweimba.


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Nicotinamide adenine dinucleotide (53-84-9) vhidhiyo

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References & chigadzirwa mhizha