Cannabidiol (CBD)

June 21, 2021

Cannabidiol (Cannabidiol, CBD) chimwe chezvinhu zvinopfuura zana zvinoshanda zvecannabis zvakanyanya kukosha pakurapa. Inodzikamisa muviri nepfungwa, inodzivirira tsinga, inovandudza kuzvimba kweganda, antioxidants, inodzora kutsvuka kweganda, uye inovaka chinodzivirira cheganda pamusoro. Kuvandudza kugona kwekuzvigadzirisa kweganda; kudzorera hutano hweganda uye kubvisa matambudziko eganda, inogona kurapa eczema nezvimwewo zvirwere.

Cannabidiol (CBD) ndicho chinhu chikuru chisiri chepfungwa checannabis uye ine zvakasiyana siyana zvezvemishonga, zvinosanganisira anti-kufunganya, anti-psychotic, antiemetic uye anti-kupisa zvivakwa.

Chemical ruzivo rweCannabidiol (CBD)

Product Name Cannabidiol poda
Synonyms (-) - Cannabidiol

(-) - trans-Cannabidiol

Epidiolex

CBD

Purity 99% tsaura / Extrapure Zindoga (CBD≥99.5%)
CAS Number 13956-29-1
Kirasi yeMishonga Cannabinoid
InChI Key QHMBSVQNZZTUGM-ZWKOTPCHSA-N
kunyemwerera CCCCCC1 = CC (= C (C (= C1) O) C2C = C (CCC2C (= C) C) C) O
Molecular Formula C21H30O2
Molecular Weight 314.5 g / mol
Monoisotopic Mass 314.224580195
Melting Point 66 ° C
Boiling Point 160 ° C - 180 ° C
Ekudzikisira hafu yeupenyu 18-32 maawa
ruvara Yakachena kujekesa yero kristaro poda
Solubility Inonyungudika mumafuta, yakanyungudika zvakanyanya muEthanol uye methanol, isina kunyungudika mumvura
SKuchengetedza temp Tembiricha yemukamuri, ramba wakaoma uye kure nechiedza
kunyoresa Zvekutsvagisa kwesainzi chete, kana sezvinhu zvakasarudzika zvekusimudzira zvigadzirwa, kana kutengeswa munyika dziri pamutemo nematunhu ekunze. Ndokumbira utarise kuti zvigadzirwa izvi hazvifanire kudyiwa zvakananga kana kushandiswa pakurapwa muChina mainland
Yedu Core Kubatsira l 100% kudzvanywa kwepanyama, kugadzirwa kwemaindasitiri, kugadzikana kwakasimba

k Vimbiso yehutano (GMPC, ISO22716, KOSHER, HALAL)

l Chechitatu-bato rabhoritari yakaedzwa, yakagadzikana uye yakakwira zvemukati zveCBD, THC yemahara

l Nzira HPLC. Huremu hwesimbi, zvisaririra uye hutachiona hunosangana nemiyero yeCP, JP neUSP

 

Chii chinonzi Cannabidiol (CBD)? Tsananguro yeCannabidiol

Cannabidiol imakemikari muCannabis sativa chirimwa, inozivikanwawo sembanje kana hemp. Anopfuura makumi masere emakemikari, anozivikanwa se cannabinoids, akaonekwa muCannabis sativa chirimwa. Kunyange delta-80-tetrahydrocannabinol (THC) iri chinhu chikuru chinobatika mbanje, cannabidiol inowanikwawo kubva kuhemp, iyo inongova nezviyero zvidiki-diki zveTC. Ose ari maviri hemp nembanje rudzi rweCannabis sativa, asi nekusiyana kwakasiyana.

  • Mbanje inokura nezvikamu zvepamusoro zve THC (psychoactive; inokonzeresa kunzwa kwe "yakakwira"), uye yakaderera zvikamu zveCBDD (isinganetsi).
  • Hemp inokura nezvikamu zvakakwirira zveCannabidiol (CBD), uye zvikamu zvakaderera zveTC.

Kunyangwe THC iri nyore inonyanya kuzivikanwa cannabinoid nekuda kweayo psychoactive mhedzisiro, Cannabidiol (CBD) yakawana traction nekuda kwayo isinganetsi [2], mishonga yekurapa. Sekureva kweWorld Health Association, CBD haina kupindwa muropa, haina zviratidzo zvekubvisa, uye ine chimiro chakachengetedzeka, saka hazvishamise kuti vazhinji vari kutendeukira kuCannabidiol (CBD) poda kune ayo akawanda ekurapa mabhenefiti. Kunyanya kukosha, CBD poda inogona kubatsira kudzora kusagadzikana kwekushushikana [1], mamiriro ekuzvimba, uye kurwadziwa kusingaperi.

Phcoker cannabidiol upfu, 100% zvakasununguka zvicherwa kubva kumaindasitiri hemp, THC yemahara.

Cannabidiol inonyanya kushandiswa pakubata chirwere (pfari). Iyo inoshandiswawo kunetsekana [1], kurwadziwa, mhasuru kusagadzikana kunonzi dystonia, chirwere cheParkinson, chirwere cheCrohn, uye mamwe mamiriro mazhinji, asi hapana humbowo hwakanaka hwesainzi hunotsigira izvi zvinoshandiswa.

 

Cannabidiol (CBD) uye THC hukama

CBD ine hukama hwakaomarara nevamwe vayo cannabinoid delta-9-tetrahydrocannabinol (THC), inova chinhu chikuru chinoshanda mu cannabis, uye inokonzeresa mhedzisiro yayo mbanje kana hashish.

Kusiyana neTHC, CBD haisi yakanangana nehutano hwepfungwa mupfungwa yekuti haipe chero euphoria kana 'yakakwira'. Izvi hazvina kufanana nekutaura kuti CBD haina zvachose psychoactive. Pakutanga, pane humbowo hwakawanda hwekuti CBD inogadzirisa mhedzisiro yeTHC. [8] [10]

Chechipiri, vashoma vevanhu (vangangosvika mashanu muzana) vanotaura nezvekuchinja-chinja mhedzisiro yeCDD, nenzira imwechete iyo vamwe varwere vanogona kusangana nemhedzisiro kubva kuTylenol kana Advil. Nekudaro, zvinofungidzirwa kuti yakawanda yemishumo yakadaro inobva mukudya CBD iyo ine zvisaririra zve THC. Nekudaro kukosha kwekutsvaga Cannabidiol kubva kunzvimbo dzemhando yepamusoro.

 

Cannabidiol inoshanda sei? CBD Mashandiro Ekuita

CBD uye THC zvinopindirana nemitumbi yedu nenzira dzakasiyana siyana. Imwe yenzira huru ndeyekuteedzera uye kuwedzeredza mhedzisiro yemakemikari mumitumbi yedu anonzi "endogenous cannabinoids" - yakatumidzwa kudaro nekuda kwekufanana kwavo nemakomponi anowanikwa mumuti wecannabis.

Cannabidiol powder ine zvinokanganisa uropi. Icho chaicho chikonzero cheiyi mhedzisiro hachina kujeka. Nekudaro, cannabidiol inoita kunge inodzivirira kuparara kwemakemikari muuropi ayo anokanganisa marwadzo, kushushikana, uye kushanda kwepfungwa. Kudzivirira kuparara kwekemikari iyi uye kuwedzera huwandu hwayo muropa zvinoita sekuderedza zviratidzo zvepfungwa zvine chekuita nemamiriro akaita seschizophrenia. Cannabidiol (CBD) inogona zvakare kuvharira mamwe epfungwa anoshanda e delta-9-tetrahydrocannabinol (THC). Zvakare, cannabidiol inoita kunge inoderedza marwadzo uye kushushikana [1].

 

CBD uye iyo Endocannabinoid System (ECS)

ECS yakawanikwa muma1990 uye inofungidzirwa kuve imwe yeanonyanya kukosha uye makuru masisitimu ekugamuchira kuchengetedza hutano hwakanaka uye yave ichizivikanwa seyakakosha modulatory system mukushanda kwehuropi, endocrine uye immune immune tishu.

Sayenzi ichangoburwa yaona kuti ECS haingopindure kune Endogenous cannabinoids inogadzirwa mumuviri asiwo inopindura kune ekunze Phytocannabinoids kana CBD senzira yekusimudzira mitumbi ECS basa. [7]

Mukati meECS pane zvinogamuchirwa CB1 uye CB2, iri mumuviri wese. Aya mauroni rudzi rwechizarira, iine cannabinoids inoshanda sekiyi. CB1 zvinogamuchirwa zviripo muhuwandu hwepamusoro muuropi, kunyanya muHypothalamus, Hippocampus uye Amygdala. CB2 zvinogamuchirwa zvinowanzoitika kazhinji mu spleen, tonsils, thymus uye immune immune masero. Iyo endocannabinoid system inotamba chinzvimbo chekutora mu homeostasis.

CBD haibatanidzi zvakananga ne cannabinoid receptors (CB1 uye CB2) [9], asi pachinzvimbo, inokurudzira iyo endocannabinoid system kuburitsa yayo cannabinoids. Uye zvakare, inononoka kuputsa kwavo nekudzivirira iyo FAAH enzyme, saka iyo endocannabinoids inogona kugara mumuviri wako kwenguva yakareba. CBD inoshamisa zvinoshamisa cannabinoid uye kudyidzana kwayo neiyo endocannabinoid system inoda kuongororwa zvakadzama kuti iratidze kugona kwayo kwakazara.

 

Ko CBD zviri pamutemo here? Cannabidiol chepfu

CBD chikamu chisiri chidhakwa chemuti wecannabis une simba rakakura rekuporesa [2]. Cannabidiol (CBD) yakawana traction nekuda kwayo isiri-inodhakisa, kubatsira kwemishonga. Sekureva kweWorld Health Association, CBD haina kupindwa muropa, haina zviratidzo zvekubvisa, uye ine mbiri yekuchengetedza. Nepo iyo Chikafu neDrug Administration (FDA) isingatarise kuchena kana kuchengetedzeka kwechinhu, CBD inoonekwa seyakachengeteka.

Kuenda kwe2018 Farm Bill kwakaita zviri pamutemo kutengesa hemp uye hemp zvigadzirwa muUS Asi izvo hazvireve kuti zvese hemp-inotorwa cannabidiol zvigadzirwa zviri pamutemo. Sezvo cannabidiol yakadzidzwa semushonga mutsva, haigone kuverengerwa zviri pamutemo muzvikafu kana zvekuwedzera zvekudya. Zvakare, cannabidiol haigone kuverengerwa muzvigadzirwa zvakatengeswa nezvirango zvekurapa. Cannabidiol inogona kungosanganisirwa muzvigadzirwa zve "cosmetic" uye chete kana iine isingasviki 0.3% THC. Asi kuchine zvimwe zvigadzirwa zvakadomwa sezvikafu zvekuwedzera pamusika zvine cannabidiol. Huwandu hwe cannabidiol iri mune izvi zvigadzirwa haigare ichitaurwa nenzira kwayo pachigadzirwa chigadzirwa.

 

Hutano mabhenefiti eCDD

Yakagamuchirwa Kurapa Pfari

Izvo zvisina-psychoactive zvimiro zveCDD zvinoita kuti zvive zvakanaka pakushandisa kwekurapa. Muna 2018, mushonga wekutanga unobvumidzwa neFDA, cannabidiol (Epidiolex), iine CBD yakaburitswa pamusika kurapa marudzi maviri akasiyana epfari [3] [4] - Dravet syndrome uye Lennox-Gastaut syndrome.

Iyo FDA yakabvumidza kurapwa kwevarwere vadiki semakore maviri ekuberekwa. Zvidzidzo zvakaratidza kuti zvaive zvine hunyanzvi mukuenzanisa neiyo placebo mukuderedza kuwanda kwekugwinha.

 

Kurapa kushushikana[1]

Kunyangwe isu tichida kumwe kutsvagurudza, 2015 yezvokurapa magazini yekuongorora chinyorwa chakatarisa paBDD nemhedzisiro yayo pane dzakawanda kusagadzikana kusagadzikana, kusanganisira zvakajairika kusagadzikana kusagadzikana, mwaka wepasisitive kusagadzikana, kutya kwekutya, uye mushure mekushungurudzika kusagadzikana kusagadzikana.

Mhedzisiro yacho yakaratidza kuti paive ne "hwakasimba humbowo hwepamberi" hwekutsigira kurapwa kwekushushikana kwekushushikana neCBD, kunyangwe kutsvagurudza kwakawanda kuchidikanwa pane kwenguva refu dosing.

 

Unogona Kurerutsa Marwadzo

Zvidzidzo zvakaratidza kuti CBD inogona kubatsira kudzikamisa kurwadziwa kusingaperi nekukanganisa endocannabinoid receptor chiitiko, ichideredza kuzvimba [6] uye nekudyidzana nemaurotransmitter. Kana iyo CBD ichikurudzira iyo TRPV1, iri kunyatso kudzivirira zviratidzo zvekurwadziwa kuti zvisvike kune imwe muviri wese. Iyo inference inopa nyaradzo kubva kuaches, kuzvimba, uye kusagadzikana.

 

Dai Kuderedza Acne

Acne chinhu chakajairika cheganda chinokanganisa zvinopfuura 9% yevagari.

Iyo inofungidzirwa kuti inokonzereswa neanoverengeka ezvinhu, anosanganisira genetics, mabhakitiriya, ari pasi pekuputika uye kuwanda kweiyo sebum, iyo oiri secretion inogadzirwa neasaceous gland mune ganda.

Kubva pane ongororo dzichangoburwa dzesainzi, CBD oiri inogona kubatsira kubata acne nekuda kweayo anti-anogumbura zvinhu [6] uye kugona kudzikisira kugadzirwa kwe sebum.

Imwe bvunzo-chubhu yekudzidza yakawana kuti CBD mafuta aidzivirira sebaceous gland maseru kubva pakavharidzira sebum yakawandisa, yakaratidza zvinopesana nekuzvimba zviito uye yakadzivirira kumisikidzwa kwe "pro-acne" vamiririri senge yekuzvimba cytokines.

Chimwe chidzidzo chakave nezvakafanana, kupedzisa kuti CBD inogona kunge iri nzira inoshanda uye yakachengeteka yekurapa acne, nekuda kwechikamu mune ayo anoshamisa anti-anogumbura hunhu.

 

Cannabidiol (CBD) kushandiswa kwehupfu & kushandiswa

Tsvagiridzo yakawedzera sezvo masisitimu ezvemagariro, emitemo uye emutemo akakomberedza kushandiswa kwecannabis ari kuvandudzwa munzvimbo zhinji dzepasi, zvichigadzira data nyowani.

Kutsvagisa kwemakiriniki pane CBD poda kwaisanganisira zvidzidzo pamusoro pekushushikana, kugona, kushushikana kwekufamba uye kurwadziwa.

CBD upfu hunogona kutorwa mumuviri munzira dzakawanda, kusanganisira nekufemera utsi kana mweya, seanerosol spray mudama, uye nemuromo. Inogona kupihwa semafuta eCDD kana semushonga wemushonga wemvura.

Kwese kuUS, vanhu vari kuzora bharisamu yeCBD pamajoini anorwadza, vachidonhedza mabiko eCDD pasi pemitauro yakaneta, vachibuda gummies dzeCBD, uye vachizvitutumadza pamafuta eBDD akazadzwa nemafuta netarisiro yekuzorora.

 

References:

[1] Cannabidiol seChinogona Kurapa Kwekunetseka Kushushikana. Kukomborera EM, Steenkamp MM, Manzanares J, Marmar CR. Neurotherapeutics. 2015 Gumiguru; 12 (4): 825-36. doi: 10.1007 / s13311-015-0387-1.

[2] Cannabidiol Migumisiro Yakashata uye Uturu. Huestis MA, Solimini R, Pichini S, Pacifici R, Carlier J, Busardò FP. Curr Neuropharmacol. 2019; 17 (10): 974-989. doi: 10.2174 / 1570159X17666190603171901.

[3] Pfari uye cannabidiol: gwara rekurapa. Arzimanoglou A, Brandl U, Muchinjikwa JH, Gil-Nagel A, Lagae L, Landmark CJ, Specchio N, Nabbout R, Thiele EA, Gubbay O, Iyo Cannabinoids International Nyanzvi Panel; Vabatsiri. Tsviyo Epfungwa. 2020 Kukadzi 1; 22 (1): 1-14. doi: 10.1684 / epd.2020.1141.

[4] Cannabidiol: Kuongororwa kweKiriniki Kubudirira uye Kudzivirirwa muChirwere. Samanta D. Pediatr Neurol. 2019 Jul; 96: 24-29. doi: 10.1016 / j.pediatrneurol.2019.03.014. Epub 2019 Kurume 22.

[5] Cannabidiol: Nyika yeunyanzvi uye matambudziko matsva ekurapa kwekushandisa. Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M. Pharmacol Ther. 2017 Jul; 175: 133-150. doi: 10.1016 / j.pharmthera.2017.02.041. Epub 2017 Kukadzi 22.

[6] Cannabidiol (CBD) uye zvakafanana nazvo: ongororo yemhedzisiro yavo pane kuzvimba. Burstein S. Bioorg Med Chem. 2015 Kubvumbi 1; 23 (7): 1377-85. doi: 10.1016 / j.bmc.2015.01.059. Epub 2015 Kukadzi 7.

[7] Iyo Endocannabinoid Sisitimu uye yayo Modulation naCannabidiol (CBD). Corroon J, Felice JF. Imwe Ther Ther Med. 2019 Jun; 25 (S2): 6-14.

[8] Kuongorora kwakakosha kweBasa reCannabinoid Makemikari delta (9) -Tetrahydrocannabinol (delta (9) -THC) uye Cannabidiol (CBD) uye Mubatanidzwa wavo mu Multiple Sclerosis Treatment. Jones É, Vlachou S.Molecule. 2020 Gumiguru 25; 25 (21): 4930. doi: 10.3390 / mamorekuru25214930.

[9] Izvo zvakasiyana CB1 uye CB2 receptor pharmacology yemiti mitatu cannabinoids: delta9-tetrahydrocannabinol, cannabidiol uye delta9-tetrahydrocannabivarin. Pertwee RG. Br J Pharmacol. 2008 Jan; 153 (2): 199-215. doi: 10.1038 / sj.bjp.0707442. Epub 2007 Sep 10.

[10] Clinical uye Preclinical Uchapupu hwekushanda Kwakabatana kweCannabidiol uye delta (9) -Tetrahydrocannabinol. Boggs DL, Nguyen JD, Morgenson D, Taffe MA, Ranganathan M. Neuropsychopharmacology. 2018 Jan; 43 (1): 142-154. doi: 10.1038 / npp.2017.209. Epub 2017 Sep 6.