Cycloastragenol poda (78574-94-4)

April 17, 2020

Cycloastragenol chinyorwa chisingaperi chinorwisa-kukwegura chekudya chinowedzera chinogadzirwa pamusika.

Cycloastragenol poda (78574-94-4) vhidhiyo

Cycloastragenol powder Specifications

Product Name Cycloastragenol poda
Kemikari Name N / A
Synonyms astramembrangenin

cyclogalegigenin

GRN510

CAG

Kirasi yeMishonga N / A
CAS Number 78574-94-4
InChIKey WENNXORDXYGDTP-UOUCMYEWSA-N
Molecular Formula C30H50O5
Molecular Wsere 490.7 g / mol
Monoisotopic Mass 490.365825 g / mol
Kubikira pfungwa N / A
Freezing Point N / A
Biological Half-Life N / A
ruvara white to beige
Skukodzera DMSO: 10 mg / mL, yakajeka
Storage Temperature 2-8 ° C
APane Cycloastragenol ndeye potent telomerase activator. Zvakare, iyo inogona kuve yakabatana ne-anti-kukwegura mune yetsika chinese mushonga.

tsananguro

Cycloastragenol chinyorwa chisingaperi chinorwisa-kukwegura chekudya chinowedzera chinogadzirwa pamusika. Iyo inoshandiswawo mune yakasvibirira skincare uye cosmetics mafomula. Cycloastragenol yakatanga kutengeswa mune zvekudyira zvikafu muU.S. muna 2007 pasi peZita-65, izvi ndosaka TA 65 kana TA65 richiri zita rinonyanya kuzivikanwa recycloastragenol.

Chii chinonzi Cycloastragenol?

Cycloastragenol imorekuru rakatorwa kubva kuAustrragalus membranaceus herb. Iyo Astragalus herb yave ichishandiswa mumushonga wechiChinese kwemazana emakore. MaChinese akataura kuti Astragalus inogona kuwedzera hupenyu uye yakashandiswa kurapa kupera simba, kutonhora, kutonhora, chirwere chemoyo uye chirwere cheshuga.

Cycloastragenol ndechimwe chezvinhu zvinoshanda muAustrragalus. Cycloastragenol ine yakafanana kemikari chimiro kune iyo yeAdragragoside IV mamorekuru, asi iyo idiki uye zvakanyanya kuwedzera bioava kuwanikwa, zvichiita kuti yakaderera madhiragi atorwe. Inotoshandiswa seye immunostimulant nekuda kwekugona kwayo kuwedzera T lymphocyte proliferation. Nekudaro, iyo iripo yakasarudzika yekudzivirira kukwegura iyo iri yekuwedzera kufarira kunharaunda yesainzi.

Cycloastragenol inomutsiridza kugadziriswa kweDNA kukuvara nekumisikidza telomerase, iyo nucleoprotein enzyme iyo inobatsira synthesis uye kukura kwe telomeric DNA. MaTelomeres anogadzirwa neakatetepa mafirizamu uye anowanikwa kumazano e chromosomes. Kuchengeta kudzikama kwavo kunoita kuti masero adzivise replicative senescence uye kusingaperi kuwedzera kuwedzera kupfuura 'Hayflick muganho'. Telomeres inotapudza nekutenderera kwega kwega kwekuparadzaniswa kwesero, kana kana ichishungurudzika oxidative kusagadzikana. Kusvika parizvino, iyi yave iri nzira isingadzivisiki yekukwegura.

Nzira dzekuita cycloastragenol

Nhamba huru yezvidzidzo yakaratidza kuti kupfupika kuri kufambira mberi kwetelomeres kwakabatana zvakanyanya nezvirwere zvakawanda zvine chekuita nezera (chirwere chemoyo, hutachiona, nezvimwewo) uye zvakare fungidziro yekufa kwepamberi muzvidzidzo zvevakweguru. Telomeres inotapudza nekutenderera kwega kwega kwekuparadzaniswa kwesero, kana kana ichishungurudzika oxidative kusagadzikana. Kusvika parizvino, iyi yave iri nzira isingadzivisiki yekukwegura.

Telomerase iserooprotein enzyme iyo inoratidzira maitiro uye kukura kwe telomeric DNA uye inomutsa kugadziriswa kweDNA kukuvara.

Cycloastragenol inoshanda uye inomutsa iyi enzyme, nokudaro ichideredza kupfupika kwetelomeres uye zvakare kuwedzera nhamba yavo. Nenzira iyi, inobvumira kureba kweiyo telomeres uye semhedzisiro, inowedzera hupenyu hwechitokisi.

Nekuda kwehuremu hwayo hushoma, Cycloastragenol inopfuura nyore kuburikidza nemudumbu remukati. Kusimudzira kwakaringana kunobvumira yakanyanya kubudirira, kunyangwe pane yakaderera dosi. Kuwedzerwa kwemazuva ese kungave kwega, kana mukubatanidzwa kana kuchinjaniswa ne, astragaloside IV, nokudaro kuchabatsira kurega kukwegura uye nekuzvarwa narwo kutarisira hupenyu hwehupenyu.

Cycloastragenol zvinobatsira

Astragalus membranaceus iri pakati pehunhu hwakakosha mune yeChinyakare Chirevo cheChinese Chemishonga semishonga yemusango yekurapa kupera simba, kurwara, maronda, maronda, hay fever, post stroke, kurarama kwenguva refu etc. Nekudaro, iwo mabhenefiti akakosha ecycloastragenol powder akaita seanopokana-kukwegura uye ekutsigira immune immune.

Cycloastragenol uye kutsigira immune

Cycloastragenol inogona kushandiswa kuchengetedza immune system, antibacterial, uye antiinflammatory, yekudzivirira kutonhora kujairika uye yekumusoro kufema system hutachiona. Iyo yakashandiswa seyemuviri wekuvandudza musimba nekuda kwekugona kukwidziridza kuwanda kweT lymphocyte. Nekudaro, izvo izvo nzanga yesayenzi iri kuwedzera kufarira ndeyekudzivirira kwayo kwakanaka kwekukwegura. Cycloastragenol inokurudzira DNA kuti igadzirise kukuvadza nekutanga telomerase uye kubvumira iyo nyukiliya proteinase yakarebesa synthesis uye kukura kwe telomere DNA.

Cycloastragenol uye anti-kukwegura

Anti-kukwegura ndeye cycloastragenol ndiyo inonyanya kuratidza kubatsira. Cycloastragenol haisi kungononoka kukwegura kwevanhu, asi nekuwedzera yakawedzera kusasimba, kuchengetedza hupfu, kuchengetedza midhiya masero, anonyanya kutorwa kubva muyeredzi yeAchragaloside (Astragaloside Ⅳ) hydrolysis.

Dzimwe Cycloastragenol inobatsira

  1. cycloastragenol poda ine mhedzisiro yekudzora kushushikana uye kuchengetedza muviri kubva kune dzakasiyana siyana kushushikana, zvinosanganisira zvemuviri, kwepfungwa, kana kushushikana kwepamoyo;
  2. cycloastragenol poda ine antioxidants, inodzivirira masero kubva kukuvara kunokonzerwa nemahara radicals;
  3. cycloastragenol poda ine mhedzisiro yekudzikisa kweropa, kurapa chirwere cheshuga nekuchengetedza chiropa.

Cycloastragenol poda mativi

Kusvika pari zvino, hapana chero chirevo kana kuongororwa kweyakaipisisa mhedzisiro kana kupokana kutora cycloastragenol supplement.

Cycloastragenol chinamatidzwa chipimo chemushonga

Cycloastragenol inyowani itsva uye kwete yakawanda mishonga yekuwedzera pamusika, uye hapana yakakurudzirwa dhesi inowanikwa. Maererano nezvakaitika kwatiri, iyo dosi yacho inosiyana nezvinangwa zvakasiyana, zera. Ehe cycloastragenol inonyanya kutyisa kupfuura Astragaloside IV ine yakakurudzirwa piritsi ndeye 50mg pazuva. Ndichiri cycloastragenol, dosing kubva pa10mg kusvika ku50mg zvese zvakanaka. Iyo yekare inoda kutora kupfuura vakuru vezera repakati. Vamwe vanopa kutanga ne5mg pazuva, uye wobva wawedzera zvishoma nezvishoma. Sezvo cycloastragenol ichibvisa zvakasikwa, zvinogona kutora nguva kuti uone mhedzisiro, dzinenge mwedzi mitanhatu.

Cycloastragenol chengetedzo

Cycloastragenol yakakwaziswa nevamwe sechishamiso chinopesana nekukwegura. Zvidzidzo zvekutanga zvinoita sekuvimbisa, zvichiratidza kuti zvine simba rekuwedzera telomere urefu, zvisinei hazvo zvichiri kushomeka kwekutarisa kwakaitwa nevezera. Uye zvakare, pane kumwe kushushikana kuti kutora Cycloastragenol kunogona kuwedzera njodzi yevamwe makenza. Nekudaro, zvidzidzo zvekutsvaga hazvina kukwanisa kutanga chero panjodzi yekenza inosanganiswa nekushandiswa kweCycloastragenol.

Cycloastragenol inoratidzika senge inovimbisa anti-kukwegura mamiriro. Kunyangwe zvisati zvaratidzirwa kuti zviwedzere hupenyu asi zvakadaro zvakaratidzirwa kuderedza makore akasiyana-siyana anobatana nema biomarkers. Mukuwedzera iyo yakaratidzirwa kuderedza zviratidzo zvekusakara senge mitsara yakanaka uye makenduru. Izvo zvinogona zvakare kuderedza njodzi yezvirwere zvinokonzeresa seAlzheimer's, Parkinson's, retinopathies, uye katarati.

Cycloastragenol poda inoshandisa uye kushandisa

Cycloastragenol inoshandiswa kurapa, kutonga, kudzivirira, & kugadzirisa kwezvirwere zvinotevera chirwere, mamiriro uye zviratidzo:

  • Kupisa
  • Apoptosis
  • Homeostasis kukanganisa
  • Cycloastragenol inogona zvakare kushandiswa zvinangwa zvisina kunyorwa pano.

Bulk cycloastragenol poda yakashandiswa pasi pesango:

  1. Inoshandiswa mumunda wekudya, inowanzoshandiswa sechikafu chinowedzera;
  2. Inoshandiswa mumunda wechigadzirwa chehutano, ichi chinyorwa chinobatsira kumuviri wemunhu;
  3. Yakashongedzwa mumunda wekushongedza, senge rudzi rwezvinhu zvakasvibirira, inogona kusanganisa cosmetics yemusango.

Reference:

  • Anti-kuchembera zvinobva cycloastragenol yakagadzirwa biotransfform.Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G.Nat Prod Res. 2019 Sep 9: 1-6. doi: 1080 / 14786419.2019.1662011.
  • Cycloastragenol: Anonakidza muvhesi mukwikwidzi wezera rinosanganiswa nezvirwere.Yu Y et al. Exp Ther Med. (2018) Anti-kuchembera kwakatorwa kwecycloastragenol inogadzirwa ne biotransformation. Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Nat Prod Res. 2019 Sep 9: 1-6. doi: 10.1080 / 14786419.2019.1662011
  • Cycloastragenol inogona kurasisa constitutive STAT3 activation uye kusimudzira paclitaxel-indened apoptosis mumasero emunhu gastric cancer cell.Hwang ST, Kim C, Lee JH, Chinnathambi A, Alharbi SA, Shair OHM, Sethi G, Ahn KS. 2019 Jun
  • Astragaloside VI uye cycloastragenol-6-O-beta-D-glucoside inosimudzira kurapa kwevaronda mu vitro uye mune vivo.Lee SY et al. Phytomedicine. (2018)