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Meclofenoxate (Centrophenoxine) (51-68-3)

Meclofenoxate (Centrophenoxine), inotengeswa pasi pezita rechiratidzo Lucidril, ndeimwe yekutanga uye yakanyanya kudzidza ……


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

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Meclofenoxate (Centrophenoxine) poda Specifications

Product Name Meclofenoxate (Centrophenoxine) (51-68-3)
Kemikari Name Clophenoxate;
Meclophenoxate;
Clofenoxin;
Proseryl;
2- (dimethylamino) ethyl 2- (4-chlorophenoxy) acetate
muchiso Name N / A
Kirasi yeMishonga Anti-Allergic Agents, Antineoplastic Magenge, Antiparasitic Age
CAS Number 51-68-3
InChIKey XZTYGFHCIAKPGJ-UHFFFAOYSA-N
Molecular Formula C12H16ClNO3
Molecular Wsere 257.71 g / mol
Monoisotopic Mass 257.081871 g / mol
Kubikira pfungwa 345.941 ° C pa 760 mmHg
Freezing Point N / A
Biological Half-Life 2-4 maawa
ruvara chena
Skukodzera Mvura Solubility: 2.9 mg / mL
Storage Temperature -20 ° C
APane Centrophenoxine powder yakashandisa mune nootropics zvinodhaka uye zvekudya zvekuwedzera.

Meclofenoxate (Centrophenoxine) kutarisisa

Meclofenoxate (Centrophenoxine), inotengeswa pasi pezita rechiratidzo Lucidril, ndeimwe yekare uye inonyanya kudzidza zvidzidzo zve nootropics kana inonzi "yakangwara" zvinodhaka. Iyo inonyatso kuzivikanwa uye inoremekedzwa nootropic yakazviratidza iyo kweanopfuura makumi mashanu emakore ekushandiswa uye akaomarara kliniki kuyedzwa.

Kwakatanga kuvandudzwa muna 1959 nemasayendisiti kuFrench National Science Science Center senzira yekurapa chirwere cheAlzheimer, kusakwana kweropa kuenda kuhuropi, ‍ uye nezera-rine hukama nekuziva kuderera, mushonga uyu wakashandiswa zvakanyanya pakurapa chirwere chinobatana nehuropi. seAlzheimer's uye kuderera kwemweya. Izvo zvinoshandiswawo nevanhu vane hutano kukwidziridza ndangariro nekuziva basa uye kugadzirisa hutano hwehuropi hwese.

Tsvagurudzo yakaratidza centrophenoxine poda kuva ine simba ndangariro boost uye anti-kukwegura mumiririri.

MuEurope, yakarongedzerwa kurapwa kwekukanganisika nezera rekukanganwa kurasikirwa, asi inowanikwa pamusoro pechibvumirano sekuwedzera kwekudya muUS neCanada, uko inowanzo shandiswa pazvinhu zvayo zvekuziva zvinowedzera.

Chii chinonzi Meclofenoxate (Centrophenoxine)?

Centrophenoxine yakashandiswa sechairo chinowedzera chekudya chayo chekukwanisa kuyeuka-kuwedzera simba.

Centrophenoxine isanganiswa yemakemikari maviri:

Dimethyl-aminoethanol (DMAE), chinova chinhu chakasikwa chinowanikwa mune zvimwe zvekudya (hove, hove dzegungwa) uye mune zvidiki zvidiki muuropi. Iyo inopa choline uye ine zvinogadzirisa uropi.

Parachlorphenoxyacetic acid (pCPA), inguva yekugadzirwa kwemahomoni ekukura kwezvirimwa anonzi "auxins".

DMAE ndiyo huru inoshanda chikamu mune uyu mushonga. DMAE haina kuyambuka ropa-brain barriers. Nekudaro, mukati metrophenoxine, inogona kuenda kuburikidza neropa-brain barriers uye kupinda muuropi zvinobudirira

Kana ichinge yanyudzwa mumuviri, chikamu chesroprophenoxine chinodambura muDMAE uye pCPA muchiropa. DMAE inobva yashandurwa kuva choline, nepo yasara centrophenoxine inotenderera mumuviri wese.

Meclofenoxate (Centrophenoxine) inobatsira

Centrophenoxine inogona kubatsira kurwisa kenza.

Centrophenoxine inogona kubatsira zviratidzo zvekunonoka dyskinesia.

Centrophenoxine inosimudzira ndangariro uye kudzidza, inogona kuvandudza ndangariro muvarwere vepfungwa.

Centrophenoxine yakaratidzirwa kunatsiridza kuumbwa, kuchengetwa, uye kudzoswa kwendangariro. Kuumbwa kwemusoro kunovandudzwa kana isu tine yakakwirira mwero acetylcholine. Tichifunga nezve chokwadi chekuti Centrophenoxine inosimudzira mabasa akasiyana-siyana ecolinergic, chimwe chinhu chinogadzirwa ndeye choline, pakati pemamwe phospholipids akasiyana

Yakavandudzwa Kunzwisisa Mabasa

Centrophenoxine inogona kushandiswa seDMAE prodrug uye izvi zvakakosha, sezvo iyi molekyumu yakanyatsoshanda pakudzora mamwe mamorekuru anokuvadza anovaka mukati mehuropi izvo zvinogona kukonzera kuderedzwa kwakanyanya mumabasa ekuziva. Nemamorekuru aya abviswa, vanhu vakura vanogona kudzora kukwegura kwavo vodzoreredza zvimwe zvinokonzeresa zvekukwegura.

Centrophenoxine ine anti-Kuchembera uye Neuroprotential Zvivakwa

Centrophenoxine yakaratidzirwa kuwedzera hupenyu hwemakonzo kusvika ku50%.

Centrophenoxine inovandudza Mood uye Kukurudzira, zvinogona kubatsira kuderedza kunetseka.

Zvidzidzo zvemhuka zvinoratidza kuti centrophenoxine ine zviyero zvekudzivirira- kushushikana.‍

Meclofenoxate (Centrophenoxine) kugayiwa kwezvokudya

Centrophenoxine inonyanya kushanda nekununura nekusimudzira zviito zve choline. Choline ndiyo yekutanga kweacetylcholine, yakakosha uye isina mutsetse neurotransmitter yakabatana zvine simba nekuziva acuity, plasticity, uye ndangariro. Izvo hazvisi kujeka kuti chaizvo sei centrophenoxine inowedzera mazinga eiyo choline uye acetylcholine, asi inofungidzirwa kuti inogona kungozviputsa pasi kuenda kune choline kana kuti inoshandukira kune inopindirana phospholipid iyo ipapo inoshandiswa kugadzira acetylcholine. Pasinei negwara, iyo cholinergic kugona kunoita iyo inoita centrophenoxine yakadaro ine simba potentiator nootropic mune yayo chaiyo.

Kuwedzera kukwidziridzwa kweacetylcholine kugadzirwa, centrophenoxine inozivikanwawo seine simba neuro simba iyo inomutsa huwandu hwechiitiko chehuropi nekuvandudza kugaya glucose uye kuwedzera oksijeni kutora. Nekuita izvi, centrophenoxine inoita kuti huropi hushande zvakanyanya, nekudaro ichivandudza kutarisa, kuisa pfungwa, uye kujekesa pfungwa, kubvisa iyo inonzi hunhu hwehuropi. Seye antioxidant ine simba, inovhara madhizaina akasununguka, ichibvisa hupfu uye inoshanda mukugadziriswa kwemasero akakuvara. Chekupedzisira, inodzosera kuchembera kwekuziva nekudzoreredza kana kubvisa kuvaka-zvigadzirwa zvemarara marara anoonekwa se "kupfeka uye kubvarura pigment."

Meclofenoxate (Centrophenoxine) migumisiro uye kuchengeteka.

Centrophenoxine inowanzoonekwa yakachengeteka uye isina-chepfu. Iyo yave ichishandiswa kwemakore makumi mashanu pasina chero mhedzisiro mhezi dzakakura dzinoonekwa.

Izvo zvinonzi chinodzvinyirira mushonga wevakawanda vane hutano hwakanaka uye vane senile vachitambura nekurangarira ndangariro.

Nekudaro, vamwe vashandisi vakasangana nekunyorova uye zvidiki zvinokanganisa, zvinosanganisira kusvotwa, kutemwa nemusoro, kurwara nematumbu, uye kushaya hope.

Centrophenoxine hairayirwi kune vakadzi vane pamuviri nekuda kwezvinhu zveDMAE.

Meclofenoxate (Centrophenoxine) poda piritsi

Centrophenoxine inowanikwa pamusoro pekupikisa mune makaputa ane 200-300 mg imwe neimwe. Clinical miyedzo yakaedza mhedzisiro yeroprophenoxine pane yekuziva mabasa vakashandisa zuva nezuva doses ye

1,200 mg mune vakweguru vane hutano uye madhivha anosvika zviuru zviviri zvemazana mune varwere vane dementia.

Stacking

Centrophenoxine yakanaka kwazvo chinyorwa checoline, unogona kuiwana mune dzakawanda nootropic stacks - mimwe inowanzojairika ndiNoopept uye Racetams.

Centrophenoxine uye Aniracetam Stack

Heano muenzaniso wecentrophenoxine stack inosanganisira iyo yakakurumbira racetam aniracetam kukurudzira kuchengetedza ndangariro, mamiriro, kusika, apo kuderedza kunetseka.

1-2x pazuva

250 mg Centrophenoxine

750 mg Aniracetam

Centrophenoxine uye Noopept Stack

Heano muenzaniso wecentrophenoxine stack neNoopept, iyi stack inogona kugadzirisa ndangariro uye kudzidza, apo ichipa neuroprotective zvinhu.

1-2x pazuva

250 mg Centrophenoxine

20 mg Noopept

Reference:

  • Pa basa re intracellular physicochemistry mune kuwanda gene kutaura panguva yekukwegura uye mhedzisiro yeroprophenoxine. Ongororo. Zs-Nagy I et al. Arch Gerontol Geriatr. (1989)
  • Cholinergic mushonga weanpspsychotic-induced tardive dyskinesia. Tammenmaa-Aho I, Asher R, Soares-Weiser K, Bergman H. Cochrane Database Syst Rev 2018 Mar 19
  • Cytotoxic chiitiko che alkylating vamiririri muhupo hwezanarophenoxine uye zvigadzirwa zve hydrolysis. Sladek NE. J Pharmacol Exp Ther. 1977 Dec
  • Potentiation yeantitumor chiitiko checyclophosphamide ne centrophenoxine. Kanzawa F, Hoshi A, Tsuda S, Kuretani K. Gan. 1972 Aug
  • Centrophenoxine: mhedzisiro inokwegura mammary brain. Nandy K et al. J Am Geriatr Soc. (1978)
  • Misiyano yemhedzisiro yemeclofenoxate pakurasikirwa kwekuyeuka muvakweguru. Marcer D et al. Zera. (1977)

KUGADZIRIRA UYE KUDZIDZA:

Ichi Chinyorwa Kutengeswa Kwekutsvagisa Chete Chete. Mitemo Yekutengesa Nyorera. Kwete Yekushandiswa Kwevanhu, kana Kurapa, Veterinary, kana Kushandisa Kweimba.


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Meclofenoxate (Centrophenoxine) (51-68-3) vhidhiyo

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