NMN upfu (1094-61-7)

October 30, 2018

Fekitori yedu inokwanisa kuburitsa pamusoro pe1370kg Nicotinamide Mononucleotide (nmn) poda pamwedzi pasi pemamiriro eGMP.


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum
Unyanzvi: 1370kg / mwedzi

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Magadzirirwo

Product Name Raw Nicotinamide Mononucleotide (NMN) powder
Mazita anoreva zvakafanana NAMN, β-NMN, β-Nicotinamide Mononucleotide kana Beta Nicotinamide Mononucleotide; NMN;

beta-NMN

Kirasi yeMishonga Dietary supplement
CAS Number 1094-61-7
InChIKey DAYLJWODMCOQEW-TURQNECASA-N
Molecular Formula C11H15N2O8P
Molecular Kurema 334.22 g / mol
Monoisotopic Mass 334.056602 g / mol
Kunyorera Nzvimbo  166 ° C (chidimbu)
Nzvimbo Inotonhora N / A
Biological Half-Life N / A
ruvara Yakachena kune off-chena poda
Solubility  Beta-NMN inopihwa sekristaro yakasimba. Beta-NMN inogadziriswa zvishoma nezvishoma mumakemikari anogadziriswa senge ethanol, DMSO, uye dimethyl formamide. Zvekuedza kwehupenyu, tinokurudzira kuti organic solvent-yemahara mhinduro dzemvura yeBeta-NMN igadziriswe nekunyungududza yakananga crystalline solid mune aqueous buffers. Iko kusimba kweBeta-NMN muPBS, pH 7.2, ingangoita 10 mg / ml. Isu hatikurudzire kuchengetedza iyo aqueous mhinduro kweanopfuura zuva rimwe.
Kuchengetedza Tembiricha  Room temperatur;

Chengeta pa -20 ° C kweanosvika makore maviri.

kunyoresa Anti-kuchembera chikafu chinowedzera

 

Nhoroondo yeNMN

Nicotinamide mononucleotide (molecular fomula: C11H15N2O8P, CAS nhamba: 1094-61-7, inozivikanwawo seNMN, beta-Nicotinamide mononucleotide kana β-NMN) vhitamini B3 metabolite [1], inowanzoonekwa mumuviri wemunhu, uye zvakafanana chikafu senge broccoli uye kabichi mune zvidiki zvishoma [2].

NMN yakatanga kuwana chimbadzo semunhu anokwanisa kuwedzera chikafu muna 2013, mushure mekuongorora kwakabudirira kwakaitwa nemasayendisiti eHarvard pamakonzo [3,4].

NMN yakatanga kugadzirwa semubatsiri wevanhu muna 2015 [5], asi yaidhura zvakanyanya kugadzira, kudzamara nzira dzave kugadziridzwa kudzikisa mutengo wekugadzira uye kuwedzera kuchena muna 2018 [6], panguva iyo marabhoritari akagadzirirwa kugadzirwa kwemazhinji akatanga uya online.

 

Chii chinonzi NMN powder?

Nicotinamide mononucleotide (molecular fomula: C11H15N2O8P, CAS nhamba: 1094-61-7, inozivikanwawo seNMN, beta-Nicotinamide mononucleotide kana β-NMN) vhitamini B3 metabolite [1], inowanzoonekwa mumuviri wemunhu, uye zvakafanana chikafu senge broccoli uye kabichi mune zvidiki zvishoma [2].

Nicotinamide Mononucleotide (NMN) chinhu chinowanzoitika icho chiri muzvidiki mumuviri wemunhu pamwe nezvimwe zvekudya. NMN inowanika nemuromo, uye kana inotorwa nemuromo inogona kutsigira NAD + mazinga mukati mechiropa uye mhasuru tishu.

Ongororo ichangoburwa yakaratidza kuti NMN inogona kutsigira hutano hwemwoyo, kugadzirwa kwesimba, hutano hwekuziva, pamwe nehutachiona uye hutano hwepfupa. Imwe inonakidza kutsvaga kweNMN kutsvagisa ndeyekuti inogona kukurudzira kugadzirisa kweDNA uye kutsigira kumisikidzwa kwemaSIRTUIN majini ayo anofungidzirwa kuti anoita basa mukukwegura kune hutano.

 

Zvinoshanda sei?

NMN inotungamira kune iyo NAD + mamorekuru; muviri wemunhu unoda NMN kuti igadzire iyo yeNAD +.

NAD + ndiyo oxidized form yeNAD (Nicotinamide adenine dinucleotide), Morekuru rakatanga kuwanikwa muna 1906, rikawanikwa mumasero ese anorarama [7].

Kuwedzera neNAD + pachayo haisi sarudzo yekukwidziridza mazinga eNAD, nekuti yakanyanya kureruka kuyambuka membranes kupinda masero, uye nekudaro ingangotadza kukanganisa metabolism [8].

 

NMN mabhenefiti.

Imwe nzira yatinogona kutsigira nhanho dzakanaka dzeNAD + ndeyekuwedzera miviri yedu neakaitangira, nicotinamide mononucleotide (NMN).

Ongororo yazvino inoratidza kuti shanduko iyi pakati peNR neNMN inofanira kutora nzvimbo yekupinda kune mashoma maseru mhando. Izvi zvinotungamira vanotsvagurudza kuti vatende kuti NMN iri, zvirokwazvo, imwe yeanokurumidza nzira yekusimudzira kugadzirwa kweNAD. Nekudaro, Nicotinamide mononucleotide poda iri kuratidzawo kuti yavo ine anti-kukwegura mabhenefiti kupfuura ayo eNAD yekugadzira chete.

Pamusoro peNAD metabolic nzira, NMN poda inogona kuwedzerwa yakanangana nemasero pasina kushandurira kuNAD. Ichi chiitiko chinogoneswa nemapuroteni achangowonekwa ekutakura anowedzera muhuwandu mushure mekunge madanho eNAD adzikira. Mune fomu iri, NMN inobatsira kusero simba uye inobvumira yega yega yambotaurwa anti-kukwegura zvivakwa zvinokwidziridzwa nemaseru zvine kukwana kugona kukura uye kumutsidzira.

Kusarudza kuwedzera neNMN powder pamwe neNAD kunopa nzira yakatwasuka yekusimudzira maseru metabolism uye nekudaro inzira inokurumidza kuita zvakafanana. Uye zvakare, Nicotinamide mononucleotide powder yakawanikwa ichivandudza basa re insulin uye kugadzirwa, zvichizoguma nekuwedzera mabhenefiti emagetsi pamwe nekutsungirira kweglucose. Kunyanya, NMN zvinowedzera zvinogona kubatsira kushanda kurerutsa metabolic mamiriro seshuga, mafuta chiropa chirwere, uye kufutisa. [11]

 

Zvimwe Zvingave Zvikomborero zveNMN

  • Inokurudzira Vascular Hutano uye Kuyerera kweropa. [11]
  • Inovandudza Tsitsi Kutsungirira uye Simba
  • Inodzivirira Pachirwere Chemwoyo
  • Kunoderedza Njodzi Yekufutisa. [10]
  • Kunowedzera Kugadziriswa kweDNA Kugadzirisa
  • Inowedzera Basa reMitochondrial. [9]

 

Nzira yekuita yakatsiga, yakachena, yakachengeteka NMN?

Kuti uone kuti chigadzirwa chakatsiga, chechokwadi, chakachena uye chakachengeteka chinogona kuitwa sei, akateedzana ebvunzo uye ongororo yakaitwa. COA, HPLC uye HNMR mishumo inogona kupihwa.

 

Kuvandudzwa kwesimba

Nekuongorora iyo Nicotinamide mononucleotide chimiro uye kushandisa mutero kuchinjisa uye mu-situ FTIR yekutarisa nzira, zvakaonekwa kuti NMN ine mukati mechimiro chemunyu uye isoelectric poindi yemunyu wemukati ndicho chinhu chakakosha kusagadzikana kweNMN. Mvura, seimwe polar molecule, inokonzeresa kuendesa kwemagetsi mukati meNMN iyo inogona kuparadza yakanyatsogadzikana yemukati munyu masaga eNMN. Kana zvirizvo, NMN inoratidza shanduko yekuchinja inodzikisira zviri nyore, zvinoti, zvemvura muchigadzirwa uye mamorekuru emvura emahara mumhepo zvichaparadza zvakananga nzvimbo yemunyu wemukati uye nekudzora kuchena kweNMN. Uku ndiko kubudirira kukuru muNMN poda kugadzikana kutsvagisa, inova yekutanga kutanga kuvandudzwa.

Kuvandudza kugadzikana kweNMN poda mukati, vaongorori vakagadzira nyowani nyowani yeNMN nekurongeka uye kwakabatana microscopic kurongeka.

 

Kugadzikana kwakasimba, hwakareba masherufu hupenyu.

Phcoker NMN upfu hwakanyanya kurongeka uye hwakabatana, zvinonyatso kuvharira kusangana nemvura yemahara mumhepo, kuwedzera zvakanyanya kugadzikana kweNMN uye kuwedzera hupenyu hwesherufu hwechigadzirwa. Kupesana neruzivo rweNMN microscopic kurongeka, chizvarwa chekutanga sawtooth chimiro chinoratidza kusagadzikana uye kusagadzikana, nekudaro mamorekuru ese anowana kuwedzerwa kumhepo uye kunotora mamwe mvura.

 

Yakakwirira kuwanda, yakadzikama muyero uye inoshanduka maficha

NMN upfu hwakarongeka uye hwakajeka microscopic kurongeka ine yakakwira huwandu hwehuwandu uye hunyoro, izvo zvinodzivirira kusagadzikana muyero nekuda kwekumutsa guruva muchiitiko chekugadzirira. Chii chimwe, zvichaita kukanganisa yunifomu chipimo chemushonga capsules. Zvichakadaro, sezvo iine zvirinani kuyerera, Yedu NMN poda inogona kubatsira kudzikisa nguva yekugadzira uye mutengo wekugadzira panguva yekugadzira.

 

Yakavimbiswa mhando yepamusoro uye yakachena

Yetatu bato rebhu yekuyedza mishumo inofanirwa kuve inofanirwa kuongorora kuzivikanwa uye kuchena kweNNM Batch yega yega yezvigadzirwa inofanirwa kupfuudza zvakanyanya kuzviongorora uye kuyedza kwechitatu-bato. HNMR uye HPLC yekuyedza mishumo inogona kuwedzera kusimbisa huchokwadi, mhando yepamusoro uye kuchena kweNMN.

 

Phcoker ndiNicotinamide mononucleotide (NMN) inogadzira poda

Ine fekitori yega-yega, yedu yeNNN poda pamwedzi kuburitsa inosvika pamusoro pematani maviri.

 

kunyoresa

Zvizorwa mbishi zvinhu:

NMN chinhu mumuviri wemasero, uye NMN mamorekuru monomer, zvinopesana nekukwegura maitiro zviri pachena, saka zvinogona kushandiswa mukushambadzira mbishi zvinhu.

 

Zvigadzirwa zvekuchengetedza hutano:

NMN poda inogona kugadzirwa nembiriso kuvirisa, kemikari synthesis kana mu vitro enzymatic catalysis.

NMN poda inoshandiswa zvakanyanya muindasitiri yehutano.

 

Dheuteronomio:

[1] Nicotinamide mononucleotide. Kubva kuWikipedia, iyo yakasununguka encyclopedia.

[2] Yenguva Yakareba Kutungamira kweNicotinamide Mononucleotide Inogonesa Zera-Yakabatana Physiological Kupera muMakonzo. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Cell Metab. 2016 Zvita 13.

[3] Kuderedza NAD + Kunopa Pseudohypoxic State Kuvhiringidza Nyukireya-Mitochondrial Kutaurirana panguva yeKukwegura. Gomes AP, Mutengo NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Sero. 2013 Zvita 19; 155 (7): 1624-38. doi: 10.1016 / j.cell.2013.11.037.

[4] Itsva-uye inodzoserwa-Chikonzero cheKwegura. David Cameron. Harvard Medical Chikoro, Nhau & Ongororo, Zvita 19, 2013

[5] Iyo yakachengetedzwa yeNAD + inosunga homwe iyo inodzora mapuroteni-mapuroteni kusangana mukati mekukwegura Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. Sayenzi. 2017 Kurume 24; 355 (6331): 1312-1317. doi: 10.1126 / science.aad8242.

[6] Saizi Kubviswa Chromatography Maitiro Ekuchenesa kweNicotinamide Mononucleotide (NMN) kubva kuBacterial Masero. George Cătălin Marinescu, Roua-Gabriela Popescu & Anca Dinischiotu. Sayenzi Reportsvolume 8, Chinyorwa nhamba: 4433 (2018).

[7] Nicotinamide adenine dinucleotide. Kubva kuWikipedia, iyo yakasununguka encyclopedia. 2019.

[8] Kuzivikanwa kweMitochondrial NAD + mutakuri muSaccharomyces cerevisiae., Todisco S, Agrimi G, Castegna A, Palmieri F. J Biol Chem. 2006 Jan 20; 281 (3): 1524-31. Epub 2005 Mbudzi 16.

[9] Katalin Sas, Elza Szabó, László Vécsei. Mitochondria, Oxidative Stress uye iyo Kynurenine System, ine Kutarisa kune Kukwegura neNeuroprotection. Mamolekemu, 2018; DOI: 10.3390 / mamorekuru23010191.

[10] Nicotinamide mononucleotide (NMN) yekuwedzera inovandudza kukanganisa kwehukama hwehukama mumakonzo: kuenzanisa nekurovedza muviri. Oddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.

[11] Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai. Nicotinamide Mononucleotide, yakakosha NAD + Pakati, Inobata iyo Pathophysiology yeDhiet- uye Zera-Inokonzera Chirwere cheshuga muMakonzo. Cell Metab, 2011; DOI: 10.1016 / j.cmet.2011.08.014.

[12] Zvazvino Zvekudzivirira-Kukwegura Zvinodhaka: Nicotinamide Mononucleotide (NMN)