Urolithin A

April 8, 2021

Urolithin A yakaratidzirwa kukurudzira mitophagy uye nekuvandudza hutano hwemhasuru mumhuka dzekare uye mumatanho epamberi ekukwegura. Zvichakadaro, izvo zvakare zvakaratidzirwa kuyambuka iro reropa chipingaidzo, uye inogona kuve neuroprotective mhedzisiro kurwisa Alzheimer's Chirwere.

Urolithin A (1143-70-0) vhidhiyo

Urolithin A (1143-70-0)Magadzirirwo

Product Name Urolithin A upfu
Kemikari Name 3,8-dihydroxy-6H-benzo [c] chromen-6-imwe;

3,8-Dihydroxy-6H-dibenzo (b, d) pyran-6-imwe;

3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo [c] chromen-6-imwe;

6H-Dibenzo [b, d] pyran-6-imwe, 3,8-dihydroxy-;

3,8-Hydroxydibenzo-alpha-pyrone;

CAS Number 1143-70-0
InChIKey RIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILES C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
Molecular Formula C13H8O4
Molecular Wsere 228.2 g / mol
Monoisotopic Mass 228.042259 g / mol
Chinyorera 340-345 ° C
Kubikira pfungwa  527.9 ± 43.0 ° C (Zvakafanotaurwa)
Flash Point 214.2ºC
Biological Half-Life Urolithin A iripo mumuti weti kusvika maawa makumi mana nemasere mushure megiranati muto unonwa.
ruvara Muchena kune beige
Skukodzera  DMSO: 20 mg / mL, yakajeka
Storage Temperature  2-8 ° C
APane Inoshandiswa seyakawedzera chikafu uye anti-kukwegura chigadzirwa, inogona kushandiswa kudzikisa kuzvimba uye kurwisa cancer.

 

Dheuteronomio:

[1] Garcia-Munoz, Cristina; Vaillant, Fabrice (2014-12-02). "Metabolic Fate yeEllagitannins: Zvinoreva Hutano, uye Maonero Ekutsvagisa eInovhenekesa Rinoshanda Zvikafu". Kuongorora Kwakakosha muKudya Sayenzi uye Kudya. 54 (12): 1584-1598. doi: 10.1080 / 10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.

[2] Ryu, D. et al. Urolithin A induces mitophagy uye inowedzera hupenyu hwehupenyu muC C. elegans uye inowedzera mhasuru mashandiro mumakonzo. Nat. Med. 22, 879-888 (2016).

[3] "FDA GRAS chiziviso GRN Nhamba 791: urolithin A". US Kudya neDrug Administration. 20 Zvita 2018. Yakadzorerwa 25 Nyamavhuvhu 2020.

[4] Singh, A .; Andreux, P.; Blanco-Bose, W.; Ryu, D .; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). "Oral inogadziriswa urolithin A yakachengeteka uye inogadzirisa mhasuru uye mitochondrial biomarkers kune vakwegura". Innovation Mukukwegura. 1 (suppl_1): 1223–

[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). "Kuchengetedzwa kuongororwa kweurolithin A, metabolite inogadzirwa nehunhu hwemunhu microbiota pakudya kwekudya kwemuti wakatorwa ellagitannins uye ellagic acid". Chikafu uye Chemical Toxicology. 108 (Pt A): 289– doi: 10.1016 / j.fct.2017.07.050. PMID 28757461.