Chii chinonzi pyrroloquinoline quinone (pqq)?

Pyrroloquinoline quinone (PQQ) inozivikanwawo sengethoxatin ivhithamini-yakafanana necofactor yakagadzirirwa iripo mune zvakawanda zvezvidyarwa zvezvirimwa. PQQ inoitikawo sezvinoitika mumukaka wechipfuva wemunhu pamwe nemumamissy tishu.

Nekudaro, inongowanikwa muhuwandu hweminiti mune iyo yekudya saka pqq poda yakawanda kugadzirwa kunodiwa kuti uwane huwandu hwakaringana mumuviri.

PQQ yakatanga kuwanikwa secoenzyme mumabhakitiriya ayo mashandiro ayo akafanana neB-Vitamin muvanhu, uye anoita basa rekusimudzira kukura kwezvisikwa izvi.

Muvanhu, iyo inoshanda senge isina-vhitamini yekukura chinhu ine zvakawanda zvehutano hutano.

Mechanism of Action

Pyrroloquinoline quinone (pqq) inoratidza hwakawanda hutano hwehutano kuburikidza nematanho akasiyana akadai sekutungamirwa kweasina kusaina nzira, kubvisa zvemahara radicals uye redox chiitiko.

Iyo pqq nzira yekuita inosanganisira:

• Inokanganisa mashandiro emajini

Pyrroloquinoline quinone inogona kukanganisa nzira dzakasiyana-siyana dzinoratidzwa uye kunyanya mhando dzakabatanidzwa mukuita kwemitochondria. Its antioxidant chiitiko inonzi ndeye zana iro revhitamini C.

PQQ supplementation yakaratidzirwa kumutsa iyo CREB uye PGC-1a siginecha nzira dzakabatanidzwa zvakananga mumochondria biogeneis.

Maitiro senge antioxidant

Pyrroloquinoline quinone (pqq) anti-oxidative basa inonyanya kukonzerwa nekukwanisa kwayo kudzikiswa kuPQQH2 kuburikidza nekuita nemaitiro ekuderedza vamiririri senge cysteine, glutathione kana nicotinamide adenine dinucleotide phosphate (NADPH).

• Inodzivirira enzyme

Pyrroloquinoline quinone zvakare inokanganisa enzyme thioredoxin reductase 1 (TrxR1), iyo inokonzeresa iyo Nuclear factor erythroid 2-inoenderana chinhu 2 (Nrf2) zviitiko zvinokurudzira antioxidant kugadzirwa.

PQQ yakave ichizivikanwawo kudzivirira kukura kwequinoproteins (inokuvadza mapuroteni) inotungamira kuParkinson kusagadzikana.

Iyo yakakosha yakakosha (PQQ) pyrroloquinoline quinone kubatsira

Kune akawanda pyrroloquinoline quinone mabhenefiti anosanganisira:

i. PQQ inosimudzira iyo mitochondrial basa

Mitochondria ndiwo ma organelles ayo anogadzira simba mumaseru ari muchimiro cheATP kuburikidza ne cellular kufema. Ivo vanowanzoendeswa kumagetsi emagetsi echitokisi kana mafekitori emagetsi.

Kugadzirwa kwesimba ndiyo kiyi yekuva hutano.

Kushungurudzika kweMitochondrial kwakabatanidzwa nehuwandu hwekunetseka sekuderedzwa kukura, kushaya simba kwemhasuru, kushushikana kwemutsipa sechirwere chemoyo, kushushikana uye chirwere cheshuga pakati pemamwe mamiriro ehutano.

Pyrroloquinoline quinone inosimudzira basa remitochondrial nekusimudzira kugadzirwa kwemasisitondondria maseru mutsva (mitochondrial biogeneis). Izvi zvinoitika nekumisikidza kweCAMP inopindura inosunga protein 1 (CREB) uye Peroxisome proliferator-activated receptor-gamma coactivator (PGC) -1alpha, nzira dzinosimudzira mitochondrial biogeneis.

Pyrroloquinoline quinone zvakare inowedzera izvo zvinyorwa zvinoshanda sema antioxidants mukati meiyo mitochondria saka inotidzivirira kubva kune oxidative kusagadzikana.

Pqq inoenderera mberi inokonzeresa ma enzymes mune mitochondria iyo inowedzera kugadzirwa kwesimba.

Mune rat rat muenzaniso, kushomeka kwePQQ mukudya kwakanzi kudzikisira basa remuchondondrial.

pyrroloquinoline quinone mabhenefiti

ii. Inodzora kuzvimba

Kurwara kusingaperi kuri pamidzi yezvinetso zvakawanda senge chirwere chemoyo uye chirwere cheshuga. Pyrroloquinoline quinone ine antioxidant zvinhu inobatsira kuti ibvise mahara radicals nekudzivirira kuzvimba uye kukuvara kwemasero.

Kumwe kutsvakisisa kunoratidza izvozvo PQQ kuwedzerwa zvinoguma nekudzikira kunoshamisa kweakawanda mamaki ekudzivirira akadai sa nitric oxide mumazuva matatu chete.

Muchidzidzo che mbeva dziri kurwara ne rheumatoid arthritis, PQQ yakapihwa yakapihwa dziviriro kubva kuzvimba mushure me mazuva makumi mana nemana.

III. Inovandudza hutano hwehuropi uye kushanda

Pyrroloquinoline quinone ine kugona kukura kwehuropi zvakare (neurogeneis) kuburikidza nekugadzira akawanda ezvemisero kukura kwezvinhu.

Imwe fundo yakagumisa kuti pqq supplement inomutsa nerve kukura factor (NGF) synthesis uye neuron maseru.

Pyrroloquinoline quinone yakabatanidzwa nekuvandudza ndangariro uye kudzidza nekuda kwekugona kwayo kuvandudza maseru ehuropi.

Mune chidzidzo chaisanganisira vanhu makumi matanhatu nevano hutano asi vakwegura, PQQ inotungamirwa kuma 41 mg / zuva kwemavhiki gumi nemaviri yakawanikwa ichitadzisa kudzikiswa kwehuropi basa, zvakanyanya mukuteerera uye nekurangarira pfungwa.

Pyrroloquinoline quinone inogona zvakare kubatsira mukudzivirira kukuvara kwehuropi.

Muna 2012, ongororo yemakonzo akapihwa pqq kwemazuva matatu pamberi pekukuvara kwehuropi kwakawoneka kuti iyo yekuwedzera yakakwanisa kudzivirira maseru ehuropi kubva mukukuvara uku.

Iv. PQQ inovandudza kurara

Pyrroloquinoline quinone (PQQ) inobatsira mukuvandudza kugona kwako kwekurara nekudzora nguva yakatorwa kuti ubate, inowedzera nguva yekurara uye inovandudza hwakazara hwekurara.

Pyrroloquinoline quinone inogonawo kuderedza huwandu hwehomoni yekushushikana (cortisol) mukati mevanhu uye nekudaro inovandudza kurara kwavo.

Mukudzidza kwevakuru gumi neviri, PQQ yakapihwa makumi maviri mg / zuva kwemavhiki masere yakawanikwa yekuvandudza kunaka kwekurara maererano nekuwedzera kwekurara nguva uye yakotsira yekurara latency

PQQ inovandudza kurara

v. Inovandudza hutano hwemwoyo

Iko kukwanisa kwe pyrroloquinoline quinone kudzora huwandu hwe cholesterol kunoita kuti ideredze njodzi yechirwere chemoyo sekurwara.

Mukudzidza kwevakuru makumi matatu neshanu, kuwedzererwa kwepqq kwakanyanya kuderedza iyo yakaipa LDL cholesterol mazinga.

Pyrroloquinoline quinone zvakare inogadzirisa triglycerides mazinga ayo anotungamira kune yakawedzerwa mitochondrial basa. Muchidzidzo nemakonzo, ppq yakapihwa yakawanikwa yekudzikisa iwo matanho e triglyceride.

Pqq inowedzera inogona kubatsira kudzivirira kana kudzorera atherosulinosis (sitiroko). Zvimwe zvidzidzo zvakaratidza kuti ppq inogona kuderedza C-reactive protein uye trimethylamine-N-oxide ayo ari mamaki makuru echirwere ichi.

isu. Anogona kunge aripo kwenguva refu mumiriri

Pyrroloquinoline quinone inoonekwa seisingabvumwi kukura kwevhithamini nekudaro inogona kubatsira mukusimudzira kukura kwako pamwe nekusimudzira.

Pyrroloquinoline quinone basa mukurwisa kuzvimba, kudzivirira oxidative kusagadzikana uye kutsigira mitochondrial basa kunoratidzira kugona kwayo mukuwedzera hupenyu hwomunhu.

PQQ yakave yakaratidzirwazve kuti ishandise cell signaling nzira idzo dzinodzosera cellular kukwegura.

Izvo synergetic zvinokonzerwa neizvi masystem zvinogonesa PQQ kukudzivirira kubva mukukwegura uye zvakare kuwedzera hupenyu hurefu.

Mumuenzaniso wemhuka, kuwedzerwa ne pqq kwakawanikwa kuti kuderedze oxidative kusagadzikana pamwe nekuwedzera nguva yehupenyu yeanotenderera.

vii. Dziviriro kubva kune oxidative kushushikana

PQQ inosunga kumapuroteni nekudaro inhibits oxidation mumasero. Izvo zvakare zvinokwanisa kubvisa zvakasununguka radicals mumuviri.

Muchidzidzo chemhuka, pqq supplementation yakawanikwa kudzivirira oxidative-inoenderana nehoron cell kufa.

Imwe fundo yakaitwa ezvokunambira kunze kwomuviri waamai yakashuma kuti PQQ yakadzivirira yakazvimiririra chiropa mitochondria masero kubva kukuvara mushure mekunetsekana oxidative uye kubvisa superoxide radicals.

Kuenderera mberi kwekudzidza pamwe ne streptozotocin-indedu (STZ) chirwere cheshuga, PQQ yakapihwa at 20 mg / kg bodyweight kwemazuva gumi nemashanu akawanikwa achideredza serum mazinga eglucose uye lipid peroxidation zvigadzirwa, uye zvakare yakasimudza zviitiko zveantioxidants muhuga hwepfungwa chirwere cheshuga. .

Mamwe pyrroloquinoline quinone anoshandisa uye zvakanaka zvinosanganisira:

Kudzivirira kufutisa

Inovandudza immune system

Inovandudza kubereka

Inosimudzira kushanda kwekuziva uye ndangariro

Inobatsira kurwisa kuneta

Mune mamiriro ezvinhu aripano munyika, nhau dzisina kunaka nekuda kweCCIDID 19 inouya nguva dzese. Pyrroloquinoline quinone coronavirus kurwa kunogona kushandiswa. Ichi chinonakidza chinowedzera chinowedzera kusasimba kwako pamwe nekupa kwekurara rubatsiro kuti udzore kushushikana.

pyrroloquinoline quinone inoshandisa

Ndeipi mhedzisiro yemiprroloquinoline quinone (pqq)?

Kana wawana PQQ kubva kunowanikwa zvekudya hapana mhedzisiro inotarisirwa kunze kwekunge munhu asinganetsi kune zvimwe zvekudya.

Mune zvidzidzo zvemhuka nemakonzo, chirwere chetsvo chakabatana nePQQ supplementation. Mune kumwe kuongorora kunosanganisira makonzo, PQQ yakajoinirwa pa11-12 mg / kg kurema kwemuviri zvakanzi zvinokonzeresa itsvo.

Mune kumwe kuongorora kwamakonzo, PQQ pa 20 mg / kg bodyweight yakawanikwa ichikonzera uturu kune iyo itsvo uye hepatic tishu.

Rat inofa yakataurwa zvakare nehupamusoro dosi reingangoita 500 mg.

Mune vanhu, hapana chakashata pyrroloquinoline quinone mhedzisiro yakataurwa nemadhora anosvika makumi maviri mg / zuva.

Nekudaro, mune zvisingawanzo kuitika, mimwe mikana inogona kuitika pyrroloquinoline quinone mhedzisiro inogona kuitika nekuda kwekutora overdoses. Izvi zvinokanganisa zvinosanganisira kutemwa nemusoro, kupera simba, kutsumwaira, hypersensitivity uye kushaya hope.

Mlingo wePQQ

Sezvo pyrroloquinoline quinone (pqq) isati yatombobvumidzwa zvizere neFederal Drug Administration yekushandiswa kwemushonga, hapana pyrroloquinoline quinone dosage yakaiswa, kunyangwe zvimwe zvidzidzo zvakawana kuti pyrroloquinoline quinone dosages kubva 2 mg / zuva rinobatsira. Nekudaro, mazhinji ePQQ ma supplements ari muhudhi yemakumi maviri kusvika makumi mana mg.

Pyrroloquinoline quinone dosage inogona kusiyana zvichienderana nechinangwa chakatemerwa. Zvimwe zvidzidzo zvinoratidza kuti dosage ye0.075 kusvika 0.3 mg / kg pazuva inoshanda mukuvandudza mitochondria basa, nepoodhi yepamusoro yeanosvika makumi maviri mg pazuva pazuva inogona kudikanwa kurwisa kuzvimba.

Kana ikatorwa pamwe chete ne COQ10, doses ye 20 mg PQQ uye 200 mg COQ10 inorayirwa, kunyange hazvo zvimwe zvidzidzo zvichishandisa 20 mg yePQQ uye 300 mg COQ10 haina kutaurira chero mimwe miganho yakaipa.

PQQ yekuwedzera inofanirwa kutorwa nemuromo uye zvakanyanya pamberi pekudya-padumbu risina chinhu.

Saka iwe unorayirwa zvakanyanya kuti utange kubva pakaderera dosi uye wedzera sekukosha.

Uye chakakosha kucherechedzwa ndechekuti zvidzidzo zvakawanda hazvikurudzire kutora dhivha inodarika 80 mg pazuva.

Ndezvipi Zvikafu Zvizi zvine pyrroloquinoline quinone (pqq)?

Pyrroloquinoline quinone (pqq) inowanikwa mune zvakawanda zvidyarwa zvidyarwa, kunyangwe kazhinji iri muzvikamu zvakaderera kwazvo. Izvo zvidyarwa zvinowana PQQ zvakananga kubva kuivhu uye muvhu mabhakitiriya akadai methylotrophic, rhizobium, uye acetobacter bacteria.

Pqq mune mashupu emunhu anouya chikamu kubva mukudya uye chikamu kubva mukugadzirwa kwebhakitiriya.

Iwo mwero wepyrroloquinoline quinine mune izvi zvinyorwa zvekudya unosiyana zvakanyanya kubva pa0.19 kusvika ku61ng / g. Nekudaro, pqq inonyanya kuiswa mune zvinotevera zvekudya:

Pqq-Chikafu

Zvimwe zvekudya zvePQQ zvinosanganisira mabhuru emakwenzi, hova yemasitadhi, fava bhinzi, maapuro, mazai, chingwa, waini uye mukaka.

Nekuda kwehuremu hwepqq mune zvakawanda zvekudya, zvingave zvakaoma kuwana huwandu hwakaringana kukwidza mabhenefiti ane hukama ne pqq kunze kwekunge isu takanyanyisa kuwanda kwechimwe chikafu. Izvi saka zvinodikanwa kuti munhu atenge pqq kuwedzera kuti uwedzere pakudya kwakanaka.

PQQ uye COQ10

Iyo coenzyme Q10 (COQ10) inowanzoonekwa seyemochondria enhancer inoitika mumuviri wemunhu uyezve mune zvakawanda zvekudya. Izvo zvakafanana nePQQ; zvisinei, pyrroloquinoline quinine uye CQ10 inoshanda nenzira dzakasarudzika kana kushandisa akasiyana maitiro ekuvandudza mitochondrial basa.

Iyo coenzyme Q10 yakakosha cofactor inoshanda mukati meitopondria uye inoita basa rakakosha mukufambisa kwemaselula uye kushandiswa kweokisijeni mukugadzirwa kwesimba. PQQ kune rumwe rutivi inowedzera huwandu wemasisitondondria masero uye zvakare inovandudza mashandiro emitochondria.

Kana ikatorwa pamwe chete, pyrroloquinoline quinine uye CQ10, inopa synergetic miganho mukuvandudza iyo mitochondrial basa, kutidzivirira kubva kune oxidative kusagadzikana uye kutonga cellular kusaina nzira.

Tenga PQQ Supplement

Kune zvakawanda zvakanaka zvisingabviri pqq supplement poda uye iwe unofanirwa kufunga nezvekukurudzira kudya kwako nazvo. PQQ poda yekutengesa inowanikwa zviri nyore pamhepo. Nekudaro, yezvakanakisa mhedzisiro iva wakasvinura paunenge uchitenga pqq yekuwedzera kuitira kuti iwe uwane yakanyanya kunaka.

Kana iwe ukafunga kutenga pqq yakawanda poda poda ita shuwa kuti unowana kubva kune vanozivikanwa vatengesi.

References

  1. Chowanadisai W., Bauerly KA, Tchaparian E., Wong A., Cortopassi GA, Rucker RB (2010). Pyrroloquinoline quinone inomutsa mitochondrial biogeneis kuburikidza neCAMP mhinduro element-inosunga protein phosphorylation uye yakawedzera PGC-1α kutaura. Biol. Chem. 285: 142–152.
  2. Harris CB1, Chowanadisai W, Mishchuk KUTI, Satre MA, Slupsky CM, Rucker RB. (2013). Dietary pyrroloquinoline quinone (PQQ) inoshandura zviratidzo zvekuputika uye mitochondrial-inoenderana metabolism mune zvidzidzo zvevanhu. J Nutr Biochem.Zvita; 24 (12): 2076-84. Doi: 10.1016 / j.jnutbio.2013.07.008.
  3. Kumazawa T., Sato K., Seno H., Ishii A., uye Suzuki O. (1995). Nhamba dze pyrroloquinoline quinone mune zvakasiyana zvekudya. J.307: 331–333.
  4. Nunome K., Miyazaki S., Nakano M., Iguchi-Ariga S., Ariga H. (2008). Pyrroloquinoline quinone inodzivirira oxidative kusagadzikana-yakasimudzira neuronal kufa pamwe kuburikidza nekuchinja mune oxidative chimiro che DJ-1. Pharm. Bull. 31: 1321–1326.
  5. Paul Hwang & Darryn S. Willoughby (2018). Mechanisms Behind Pyrroloquinoline Quinone Supplementation pane Skeletal Muscle Mitochondrial Biogenesis: Zvinogoneka Synergistic Mhedzisiro neKurovedza muviri, Nhau yeAmerican College of Nutrition, 37: 8, 738-748, DOI: 1080 / 07315724.2018.1461146.
  6. Inobata T, Dutu D, uye Bauerly K, et al. (2006). Mavara akazara: Pyrroloquinoline quinone modulates kuwanda kwemitochondrial uye kushanda mumakonzo. J Nutriti. Feb; 136 (2): 390-6.
  7. Zhang L, Liu J, Cheng C, Yuan Y, Yu B, Shen A, Yan M. (2012). Iyo neuroprotective mhedzisiro yepyrroloquinoline quinone pane zvinoshungurudza uropi kukuvara. J Neurotrauma. Mar 20; 29 (5): 851-64.

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